Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

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Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide. / Jensen, Ditte Marie; Skovsted, Gry Freja; Lykkesfeldt, Jens; Dreier, Rasmus; Berg, Jais Oliver; Jeppesen, Jørgen Lykke; Sheykhzade, Majid; Loft, Steffen; Møller, Peter.

In: Food and Chemical Toxicology, Vol. 120, 2018, p. 321-327.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jensen, DM, Skovsted, GF, Lykkesfeldt, J, Dreier, R, Berg, JO, Jeppesen, JL, Sheykhzade, M, Loft, S & Møller, P 2018, 'Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide', Food and Chemical Toxicology, vol. 120, pp. 321-327. https://doi.org/10.1016/j.fct.2018.07.015

APA

Jensen, D. M., Skovsted, G. F., Lykkesfeldt, J., Dreier, R., Berg, J. O., Jeppesen, J. L., ... Møller, P. (2018). Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide. Food and Chemical Toxicology, 120, 321-327. https://doi.org/10.1016/j.fct.2018.07.015

Vancouver

Jensen DM, Skovsted GF, Lykkesfeldt J, Dreier R, Berg JO, Jeppesen JL et al. Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide. Food and Chemical Toxicology. 2018;120:321-327. https://doi.org/10.1016/j.fct.2018.07.015

Author

Jensen, Ditte Marie ; Skovsted, Gry Freja ; Lykkesfeldt, Jens ; Dreier, Rasmus ; Berg, Jais Oliver ; Jeppesen, Jørgen Lykke ; Sheykhzade, Majid ; Loft, Steffen ; Møller, Peter. / Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide. In: Food and Chemical Toxicology. 2018 ; Vol. 120. pp. 321-327.

Bibtex

@article{021a04f1b1eb49e791f21302e6b56232,
title = "Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide",
abstract = "Animal studies have shown that titanium dioxide (TiO2) exposure affects arterial vasomotor function, whereas little is known about the effects in arteries from humans. This study investigated vasomotor responses after direct exposure of human subcutaneous arteries to food-grade TiO2 (E171) (14 or 140 μg/ml) for 30 min and 18 h. Vasomotor responses to bradykinin, 5-hydroxytryptamine (5-HT), sarafotoxin 6c (S6c) and nitroglycerin were recorded in wire-myographs. Vasoconstrictor responses to 5-HT were increased in arteries exposed to E171 for 18 h (P < 0.05). Furthermore, an increase in S6c responses was seen in low concentration E171 exposed arteries (30 min exposure; P < 0.05). The vasorelaxation response to nitroglycerin was increased in low concentration E171 exposed arteries (30 min exposure; P < 0.05). Vasorelaxation responses to bradykinin were unaffected after treatment with E171. There was no difference in gene expression levels of intercellular cell adhesion molecule 1, vascular cell adhesion molecule 1, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 2A, endothelin receptor A and endothelin receptor B in E171 exposed arteries after exposure to TiO2 for 30 min or 18 h. In conclusion, this study shows that the same type of vasomotor dysfunction is found in artery segments of rats and humans following ex vivo exposure to E171.",
author = "Jensen, {Ditte Marie} and Skovsted, {Gry Freja} and Jens Lykkesfeldt and Rasmus Dreier and Berg, {Jais Oliver} and Jeppesen, {J{\o}rgen Lykke} and Majid Sheykhzade and Steffen Loft and Peter M{\o}ller",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
doi = "10.1016/j.fct.2018.07.015",
language = "English",
volume = "120",
pages = "321--327",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

AU - Jensen, Ditte Marie

AU - Skovsted, Gry Freja

AU - Lykkesfeldt, Jens

AU - Dreier, Rasmus

AU - Berg, Jais Oliver

AU - Jeppesen, Jørgen Lykke

AU - Sheykhzade, Majid

AU - Loft, Steffen

AU - Møller, Peter

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Animal studies have shown that titanium dioxide (TiO2) exposure affects arterial vasomotor function, whereas little is known about the effects in arteries from humans. This study investigated vasomotor responses after direct exposure of human subcutaneous arteries to food-grade TiO2 (E171) (14 or 140 μg/ml) for 30 min and 18 h. Vasomotor responses to bradykinin, 5-hydroxytryptamine (5-HT), sarafotoxin 6c (S6c) and nitroglycerin were recorded in wire-myographs. Vasoconstrictor responses to 5-HT were increased in arteries exposed to E171 for 18 h (P < 0.05). Furthermore, an increase in S6c responses was seen in low concentration E171 exposed arteries (30 min exposure; P < 0.05). The vasorelaxation response to nitroglycerin was increased in low concentration E171 exposed arteries (30 min exposure; P < 0.05). Vasorelaxation responses to bradykinin were unaffected after treatment with E171. There was no difference in gene expression levels of intercellular cell adhesion molecule 1, vascular cell adhesion molecule 1, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 2A, endothelin receptor A and endothelin receptor B in E171 exposed arteries after exposure to TiO2 for 30 min or 18 h. In conclusion, this study shows that the same type of vasomotor dysfunction is found in artery segments of rats and humans following ex vivo exposure to E171.

AB - Animal studies have shown that titanium dioxide (TiO2) exposure affects arterial vasomotor function, whereas little is known about the effects in arteries from humans. This study investigated vasomotor responses after direct exposure of human subcutaneous arteries to food-grade TiO2 (E171) (14 or 140 μg/ml) for 30 min and 18 h. Vasomotor responses to bradykinin, 5-hydroxytryptamine (5-HT), sarafotoxin 6c (S6c) and nitroglycerin were recorded in wire-myographs. Vasoconstrictor responses to 5-HT were increased in arteries exposed to E171 for 18 h (P < 0.05). Furthermore, an increase in S6c responses was seen in low concentration E171 exposed arteries (30 min exposure; P < 0.05). The vasorelaxation response to nitroglycerin was increased in low concentration E171 exposed arteries (30 min exposure; P < 0.05). Vasorelaxation responses to bradykinin were unaffected after treatment with E171. There was no difference in gene expression levels of intercellular cell adhesion molecule 1, vascular cell adhesion molecule 1, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 2A, endothelin receptor A and endothelin receptor B in E171 exposed arteries after exposure to TiO2 for 30 min or 18 h. In conclusion, this study shows that the same type of vasomotor dysfunction is found in artery segments of rats and humans following ex vivo exposure to E171.

U2 - 10.1016/j.fct.2018.07.015

DO - 10.1016/j.fct.2018.07.015

M3 - Journal article

VL - 120

SP - 321

EP - 327

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -

ID: 200150094