Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract

Research output: Contribution to journalJournal articleResearchpeer-review

Martin Blomberg Jensen, John E Nielsen, Anne Jørgensen, Ewa Rajpert-De Meyts, David Møbjerg Kristensen, Niels Jørgensen, Niels Erik Skakkebæk, Anders Juul, Henrik Leffers

The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Indeed, VDR knockout mice and VD deficient rats show decreased sperm counts and low fertility. However, the cellular response to VD is complex, since it is not solely dependent on VDR expression, but also on cellular uptake of circulating VD and presence and activity of VD metabolizing enzymes. Expression of VD metabolizing enzymes has not previously been investigated in human testis and male reproductive tract. Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa.
Original languageEnglish
JournalHuman Reproduction
Volume25
Issue number5
Pages (from-to)1303-11
Number of pages9
ISSN0268-1161
DOIs
Publication statusPublished - 1 May 2010

ID: 34048031