White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls

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White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls. / Devantier, Torben Albert; Nørgaard, Bjarne Linde; Poulsen, Mikael Kjær; Garde, Ellen; Øvrehus, Kristian Altern; Marwan, Mohamed; Achenbach, Stephan; Dey, Damini; Sørensen, Leif Hougaard; Videbech, Poul.

In: Psychosomatics, Vol. 57, No. 4, 07.2016, p. 369-377.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Devantier, TA, Nørgaard, BL, Poulsen, MK, Garde, E, Øvrehus, KA, Marwan, M, Achenbach, S, Dey, D, Sørensen, LH & Videbech, P 2016, 'White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls', Psychosomatics, vol. 57, no. 4, pp. 369-377. https://doi.org/10.1016/j.psym.2016.02.005

APA

Devantier, T. A., Nørgaard, B. L., Poulsen, M. K., Garde, E., Øvrehus, K. A., Marwan, M., Achenbach, S., Dey, D., Sørensen, L. H., & Videbech, P. (2016). White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls. Psychosomatics, 57(4), 369-377. https://doi.org/10.1016/j.psym.2016.02.005

Vancouver

Devantier TA, Nørgaard BL, Poulsen MK, Garde E, Øvrehus KA, Marwan M et al. White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls. Psychosomatics. 2016 Jul;57(4):369-377. https://doi.org/10.1016/j.psym.2016.02.005

Author

Devantier, Torben Albert ; Nørgaard, Bjarne Linde ; Poulsen, Mikael Kjær ; Garde, Ellen ; Øvrehus, Kristian Altern ; Marwan, Mohamed ; Achenbach, Stephan ; Dey, Damini ; Sørensen, Leif Hougaard ; Videbech, Poul. / White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls. In: Psychosomatics. 2016 ; Vol. 57, No. 4. pp. 369-377.

Bibtex

@article{67b29a3171424aa5b9bf505968c2f599,
title = "White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls",
abstract = "BACKGROUND: Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression. It has been proposed that carotid atherosclerosis may predispose to WMLs by inducing cerebral hypoperfusion. This hemodynamic effect of carotid atherosclerosis could be important for the formation of WMLs in depression.METHODS: The case-control study included 29 patients with late-onset major depressive disorder and 27 controls matched for sex, age, and tobacco use. WML volume, carotid intima-media thickness, and coronary plaque volume were assessed using magnetic resonance imaging, ultrasound scan, and coronary computed tomography (CT) angiography, respectively.RESULTS: The mean age for the total sample was 59.7 ± 4.7 years. There was no difference in carotid intima-media thickness between patients and controls (p = 0.164), whereas a higher WML volume in the patients was found (p = 0.051). In both patients and controls, WML volume was associated with carotid but not with coronary atherosclerosis. In adjusted multiple linear regression, a 0.1mm increase in averaged carotid intima-media thickness was associated with a 52% (95% CI: 8.4-112, p = 0.032) increase in WML volume. The association between carotid intima-media thickness and WML volume was, however, similar in patients and controls.CONCLUSIONS: In older persons aged between 50 and 70 years, WMLs do not seem to be a part of generalized atherosclerotic disease, but seem to be dependent on atherosclerosis in the carotid arteries. Carotid atherosclerosis, however, could not explain the higher WML load observed in the depressed patients, and thus, studies are needed to establish the mechanisms linking depression and WMLs.",
keywords = "Journal Article",
author = "Devantier, {Torben Albert} and N{\o}rgaard, {Bjarne Linde} and Poulsen, {Mikael Kj{\ae}r} and Ellen Garde and {\O}vrehus, {Kristian Altern} and Mohamed Marwan and Stephan Achenbach and Damini Dey and S{\o}rensen, {Leif Hougaard} and Poul Videbech",
note = "Copyright {\textcopyright} 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = jul,
doi = "10.1016/j.psym.2016.02.005",
language = "English",
volume = "57",
pages = "369--377",
journal = "Psychosomatics",
issn = "0033-3182",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls

AU - Devantier, Torben Albert

AU - Nørgaard, Bjarne Linde

AU - Poulsen, Mikael Kjær

AU - Garde, Ellen

AU - Øvrehus, Kristian Altern

AU - Marwan, Mohamed

AU - Achenbach, Stephan

AU - Dey, Damini

AU - Sørensen, Leif Hougaard

AU - Videbech, Poul

N1 - Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

PY - 2016/7

Y1 - 2016/7

N2 - BACKGROUND: Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression. It has been proposed that carotid atherosclerosis may predispose to WMLs by inducing cerebral hypoperfusion. This hemodynamic effect of carotid atherosclerosis could be important for the formation of WMLs in depression.METHODS: The case-control study included 29 patients with late-onset major depressive disorder and 27 controls matched for sex, age, and tobacco use. WML volume, carotid intima-media thickness, and coronary plaque volume were assessed using magnetic resonance imaging, ultrasound scan, and coronary computed tomography (CT) angiography, respectively.RESULTS: The mean age for the total sample was 59.7 ± 4.7 years. There was no difference in carotid intima-media thickness between patients and controls (p = 0.164), whereas a higher WML volume in the patients was found (p = 0.051). In both patients and controls, WML volume was associated with carotid but not with coronary atherosclerosis. In adjusted multiple linear regression, a 0.1mm increase in averaged carotid intima-media thickness was associated with a 52% (95% CI: 8.4-112, p = 0.032) increase in WML volume. The association between carotid intima-media thickness and WML volume was, however, similar in patients and controls.CONCLUSIONS: In older persons aged between 50 and 70 years, WMLs do not seem to be a part of generalized atherosclerotic disease, but seem to be dependent on atherosclerosis in the carotid arteries. Carotid atherosclerosis, however, could not explain the higher WML load observed in the depressed patients, and thus, studies are needed to establish the mechanisms linking depression and WMLs.

AB - BACKGROUND: Cerebral white matter lesions (WMLs) are more common in individuals with late-onset or late-life depression. It has been proposed that carotid atherosclerosis may predispose to WMLs by inducing cerebral hypoperfusion. This hemodynamic effect of carotid atherosclerosis could be important for the formation of WMLs in depression.METHODS: The case-control study included 29 patients with late-onset major depressive disorder and 27 controls matched for sex, age, and tobacco use. WML volume, carotid intima-media thickness, and coronary plaque volume were assessed using magnetic resonance imaging, ultrasound scan, and coronary computed tomography (CT) angiography, respectively.RESULTS: The mean age for the total sample was 59.7 ± 4.7 years. There was no difference in carotid intima-media thickness between patients and controls (p = 0.164), whereas a higher WML volume in the patients was found (p = 0.051). In both patients and controls, WML volume was associated with carotid but not with coronary atherosclerosis. In adjusted multiple linear regression, a 0.1mm increase in averaged carotid intima-media thickness was associated with a 52% (95% CI: 8.4-112, p = 0.032) increase in WML volume. The association between carotid intima-media thickness and WML volume was, however, similar in patients and controls.CONCLUSIONS: In older persons aged between 50 and 70 years, WMLs do not seem to be a part of generalized atherosclerotic disease, but seem to be dependent on atherosclerosis in the carotid arteries. Carotid atherosclerosis, however, could not explain the higher WML load observed in the depressed patients, and thus, studies are needed to establish the mechanisms linking depression and WMLs.

KW - Journal Article

U2 - 10.1016/j.psym.2016.02.005

DO - 10.1016/j.psym.2016.02.005

M3 - Journal article

C2 - 27036850

VL - 57

SP - 369

EP - 377

JO - Psychosomatics

JF - Psychosomatics

SN - 0033-3182

IS - 4

ER -

ID: 174836642