White matter tract integrity in treatment-resistant gambling disorder

Research output: Contribution to journalJournal articleResearchpeer-review

  • Samuel R. Chamberlain
  • Katherine Derbyshire
  • Richard E. Daws
  • Brian L. Odlaug
  • Eric W. Leppink
  • Jon E. Grant
Background: Gambling disorder is a relatively common psychiatric disorder recently re-classified within the DSM-5 under the category of ‘substance-related and addictive disorders’.
Aims: To compare white matter integrity in patients with gambling disorder with healthy controls; to explore relationships between white matter integrity and disease severity in gambling disorder.
Method: In total, 16 participants with treatment-resistant gambling disorder and 15 healthy controls underwent magnetic resonance imaging (MRI). White matter integrity was analysed using tract-based spatial statistics.
Results: Gambling disorder was associated with reduced fractional anisotropy in the corpus callosum and superior longitudinal fasciculus. Fractional anisotropy in distributed white matter tracts elsewhere correlated positively with disease severity.
Conclusions: Reduced corpus callosum fractional anisotropy is suggestive of disorganised/damaged tracts in patients with gambling disorder, and this may represent a trait/vulnerability marker for the disorder. Future research should explore these measures in a larger sample, ideally incorporating a range of imaging markers (for example functional MRI) and enrolling unaffected first-degree relatives of patients.
Original languageEnglish
JournalBritish Journal of Psychiatry
Issue number6
Pages (from-to)579-584
Number of pages8
Publication statusPublished - Jun 2016

ID: 163126638