Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis

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Standard

Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. / Wils, Regitze Sølling; Gotfredsen, Ditte Resendal; Hjorthøj, Carsten; Austin, Stephen F; Albert, Nikolai; Secher, Rikke Gry; Thorup, Anne Amalie Elgaard; Mors, Ole; Nordentoft, Merete.

In: Schizophrenia Research, Vol. 182, 2017, p. 42-48.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wils, RS, Gotfredsen, DR, Hjorthøj, C, Austin, SF, Albert, N, Secher, RG, Thorup, AAE, Mors, O & Nordentoft, M 2017, 'Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis', Schizophrenia Research, vol. 182, pp. 42-48. https://doi.org/10.1016/j.schres.2016.10.030

APA

Wils, R. S., Gotfredsen, D. R., Hjorthøj, C., Austin, S. F., Albert, N., Secher, R. G., ... Nordentoft, M. (2017). Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. Schizophrenia Research, 182, 42-48. https://doi.org/10.1016/j.schres.2016.10.030

Vancouver

Wils RS, Gotfredsen DR, Hjorthøj C, Austin SF, Albert N, Secher RG et al. Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. Schizophrenia Research. 2017;182:42-48. https://doi.org/10.1016/j.schres.2016.10.030

Author

Wils, Regitze Sølling ; Gotfredsen, Ditte Resendal ; Hjorthøj, Carsten ; Austin, Stephen F ; Albert, Nikolai ; Secher, Rikke Gry ; Thorup, Anne Amalie Elgaard ; Mors, Ole ; Nordentoft, Merete. / Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis. In: Schizophrenia Research. 2017 ; Vol. 182. pp. 42-48.

Bibtex

@article{7e3812e415f146c5b3d312af07dba34b,
title = "Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis",
abstract = "BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61{\%} of the patients from the original cohort attended the 10-year follow up and 30{\%} of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.",
keywords = "Adolescent, Adult, Antipsychotic Agents, Female, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Psychotic Disorders, Recurrence, Treatment Outcome, Young Adult, Journal Article",
author = "Wils, {Regitze S{\o}lling} and Gotfredsen, {Ditte Resendal} and Carsten Hjorth{\o}j and Austin, {Stephen F} and Nikolai Albert and Secher, {Rikke Gry} and Thorup, {Anne Amalie Elgaard} and Ole Mors and Merete Nordentoft",
note = "Copyright {\circledC} 2016 Elsevier B.V. All rights reserved.",
year = "2017",
doi = "10.1016/j.schres.2016.10.030",
language = "English",
volume = "182",
pages = "42--48",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis

AU - Wils, Regitze Sølling

AU - Gotfredsen, Ditte Resendal

AU - Hjorthøj, Carsten

AU - Austin, Stephen F

AU - Albert, Nikolai

AU - Secher, Rikke Gry

AU - Thorup, Anne Amalie Elgaard

AU - Mors, Ole

AU - Nordentoft, Merete

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

AB - BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

KW - Adolescent

KW - Adult

KW - Antipsychotic Agents

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Psychiatric Status Rating Scales

KW - Psychotic Disorders

KW - Recurrence

KW - Treatment Outcome

KW - Young Adult

KW - Journal Article

U2 - 10.1016/j.schres.2016.10.030

DO - 10.1016/j.schres.2016.10.030

M3 - Journal article

VL - 182

SP - 42

EP - 48

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 188192314