Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. / Kermanizadeh, Ali; Jacobsen, Nicklas R.; Roursgaard, Martin; Loft, Steffen; Møller, Peter.

In: Heliyon, Vol. 3, No. 11, e00458, 11.2017, p. 1-21.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kermanizadeh, A, Jacobsen, NR, Roursgaard, M, Loft, S & Møller, P 2017, 'Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice', Heliyon, vol. 3, no. 11, e00458, pp. 1-21. https://doi.org/10.1016/j.heliyon.2017.e00458

APA

Kermanizadeh, A., Jacobsen, N. R., Roursgaard, M., Loft, S., & Møller, P. (2017). Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon, 3(11), 1-21. [e00458]. https://doi.org/10.1016/j.heliyon.2017.e00458

Vancouver

Kermanizadeh A, Jacobsen NR, Roursgaard M, Loft S, Møller P. Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. Heliyon. 2017 Nov;3(11):1-21. e00458. https://doi.org/10.1016/j.heliyon.2017.e00458

Author

Kermanizadeh, Ali ; Jacobsen, Nicklas R. ; Roursgaard, Martin ; Loft, Steffen ; Møller, Peter. / Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. In: Heliyon. 2017 ; Vol. 3, No. 11. pp. 1-21.

Bibtex

@article{3a5d49457b7a48e884eab0bd4150962d,
title = "Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice",
abstract = "The utilisation of nanoparticles as the means of targeted delivery of therapeutics and/or imaging agents could greatly enhance the specific transport of biologically active payloads to target tissues while avoiding or reducing undesired side-effects. To allow for this to become a reality, the question of potential toxicological effects needs to be addressed. In the present investigation, a cationic liposome with prospective for medical applications was constructed and thoroughly assessed for any material-induced hepatic adverse effects in vivo − in healthy and alcoholic hepatic disease models and in vitro − (HepG2 cells). The data demonstrated that intravenous injection of liposomes did not cause any significant in vivo hepatic toxicity (inflammation, alterations in blood parameters, anti-oxidant depletion, acute phase response and histopathology) at doses of 200 μg per mouse in either healthy or chronically alcohol fed mice. Additionally, the in vitro material-induced adverse effects (cytotoxicity, inflammation or albumin secretion) were all also minimal. The data from this study demonstrated that the intravenous injection of cationic liposomes does not cause hepatic toxicity. This investigation is important as it investigates the toxicity of a nano-sized material in a model of alcoholic hepatic disease in vitro and in vivo. This is an area of research in the field of nanotoxicology that is currently almost entirely overlooked.",
keywords = "Nanoparticles, Pharmaceutical science, Toxicology",
author = "Ali Kermanizadeh and Jacobsen, {Nicklas R.} and Martin Roursgaard and Steffen Loft and Peter M{\o}ller",
year = "2017",
month = "11",
doi = "10.1016/j.heliyon.2017.e00458",
language = "English",
volume = "3",
pages = "1--21",
journal = "Heliyon",
issn = "2405-8440",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice

AU - Kermanizadeh, Ali

AU - Jacobsen, Nicklas R.

AU - Roursgaard, Martin

AU - Loft, Steffen

AU - Møller, Peter

PY - 2017/11

Y1 - 2017/11

N2 - The utilisation of nanoparticles as the means of targeted delivery of therapeutics and/or imaging agents could greatly enhance the specific transport of biologically active payloads to target tissues while avoiding or reducing undesired side-effects. To allow for this to become a reality, the question of potential toxicological effects needs to be addressed. In the present investigation, a cationic liposome with prospective for medical applications was constructed and thoroughly assessed for any material-induced hepatic adverse effects in vivo − in healthy and alcoholic hepatic disease models and in vitro − (HepG2 cells). The data demonstrated that intravenous injection of liposomes did not cause any significant in vivo hepatic toxicity (inflammation, alterations in blood parameters, anti-oxidant depletion, acute phase response and histopathology) at doses of 200 μg per mouse in either healthy or chronically alcohol fed mice. Additionally, the in vitro material-induced adverse effects (cytotoxicity, inflammation or albumin secretion) were all also minimal. The data from this study demonstrated that the intravenous injection of cationic liposomes does not cause hepatic toxicity. This investigation is important as it investigates the toxicity of a nano-sized material in a model of alcoholic hepatic disease in vitro and in vivo. This is an area of research in the field of nanotoxicology that is currently almost entirely overlooked.

AB - The utilisation of nanoparticles as the means of targeted delivery of therapeutics and/or imaging agents could greatly enhance the specific transport of biologically active payloads to target tissues while avoiding or reducing undesired side-effects. To allow for this to become a reality, the question of potential toxicological effects needs to be addressed. In the present investigation, a cationic liposome with prospective for medical applications was constructed and thoroughly assessed for any material-induced hepatic adverse effects in vivo − in healthy and alcoholic hepatic disease models and in vitro − (HepG2 cells). The data demonstrated that intravenous injection of liposomes did not cause any significant in vivo hepatic toxicity (inflammation, alterations in blood parameters, anti-oxidant depletion, acute phase response and histopathology) at doses of 200 μg per mouse in either healthy or chronically alcohol fed mice. Additionally, the in vitro material-induced adverse effects (cytotoxicity, inflammation or albumin secretion) were all also minimal. The data from this study demonstrated that the intravenous injection of cationic liposomes does not cause hepatic toxicity. This investigation is important as it investigates the toxicity of a nano-sized material in a model of alcoholic hepatic disease in vitro and in vivo. This is an area of research in the field of nanotoxicology that is currently almost entirely overlooked.

KW - Nanoparticles

KW - Pharmaceutical science

KW - Toxicology

U2 - 10.1016/j.heliyon.2017.e00458

DO - 10.1016/j.heliyon.2017.e00458

M3 - Journal article

VL - 3

SP - 1

EP - 21

JO - Heliyon

JF - Heliyon

SN - 2405-8440

IS - 11

M1 - e00458

ER -

ID: 188745146