Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology

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Standard

Telomere dynamics and cellular senescence : an emerging field in environmental and occupational toxicology. / Møller, Peter; Wils, Regitze Sølling; Jensen, Ditte Marie; Andersen, Maria Helena Guerra; Roursgaard, Martin.

In: Critical Reviews in Toxicology, Vol. 48, No. 9, 2018, p. 761-788.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Møller, P, Wils, RS, Jensen, DM, Andersen, MHG & Roursgaard, M 2018, 'Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology', Critical Reviews in Toxicology, vol. 48, no. 9, pp. 761-788. https://doi.org/10.1080/10408444.2018.1538201

APA

Møller, P., Wils, R. S., Jensen, D. M., Andersen, M. H. G., & Roursgaard, M. (2018). Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology. Critical Reviews in Toxicology, 48(9), 761-788. https://doi.org/10.1080/10408444.2018.1538201

Vancouver

Møller P, Wils RS, Jensen DM, Andersen MHG, Roursgaard M. Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology. Critical Reviews in Toxicology. 2018;48(9):761-788. https://doi.org/10.1080/10408444.2018.1538201

Author

Møller, Peter ; Wils, Regitze Sølling ; Jensen, Ditte Marie ; Andersen, Maria Helena Guerra ; Roursgaard, Martin. / Telomere dynamics and cellular senescence : an emerging field in environmental and occupational toxicology. In: Critical Reviews in Toxicology. 2018 ; Vol. 48, No. 9. pp. 761-788.

Bibtex

@article{31371d43f59b48ad9d729b3a779756f4,
title = "Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology",
abstract = "There has been a steady output of epidemiological studies linking environmental and occupational exposures to altered telomere length, showing mainly positive associations with persistent organic pollutants, inverse association with cadmium and inconsistent results with arsenic and lead. A bell-shaped dose-response relationship has been observed for ionizing radiation with telomere shortening at a low dose. Long-term air pollution is associated with telomere shortening, whereas the short-term exposure studies have shown mixed results. There are surprisingly few studies on telomere dynamics in animals. Studies on telomere dynamics and senescence in target tissues of animal strains used in toxicology are warranted. Cell culture studies on ionizing radiation have shown mixed results on telomere length, whereas both telomerase activity and cellular senescence are increased. Studies on persistent organic pollutants indicate telomere shortening, decreased telomerase activity and increased cellular senescence. Cell culture studies on heavy metals and air pollution particles are inconsistent. There is no coherent relationship between exposures, oxidative stress, telomere length, telomerase activity and cellular senescence in experimental studies on environmental or occupational exposures. This may be due to differences in exposure levels (including dose rate), exposure time and models (i.e. cell types and animal strains). Guidelines are needed for best practices on assays for telomere dynamics and cellular senescence in toxicology. However, it deserves notice that experimental studies in cells and animals have revealed important information on the effects of environmental and occupational agents on the maintenance of telomeres and cellular senescence.",
author = "Peter M{\o}ller and Wils, {Regitze S{\o}lling} and Jensen, {Ditte Marie} and Andersen, {Maria Helena Guerra} and Martin Roursgaard",
year = "2018",
doi = "10.1080/10408444.2018.1538201",
language = "English",
volume = "48",
pages = "761--788",
journal = "Critical Reviews in Toxicology",
issn = "1040-8444",
publisher = "Taylor & Francis",
number = "9",

}

RIS

TY - JOUR

T1 - Telomere dynamics and cellular senescence

T2 - an emerging field in environmental and occupational toxicology

AU - Møller, Peter

AU - Wils, Regitze Sølling

AU - Jensen, Ditte Marie

AU - Andersen, Maria Helena Guerra

AU - Roursgaard, Martin

PY - 2018

Y1 - 2018

N2 - There has been a steady output of epidemiological studies linking environmental and occupational exposures to altered telomere length, showing mainly positive associations with persistent organic pollutants, inverse association with cadmium and inconsistent results with arsenic and lead. A bell-shaped dose-response relationship has been observed for ionizing radiation with telomere shortening at a low dose. Long-term air pollution is associated with telomere shortening, whereas the short-term exposure studies have shown mixed results. There are surprisingly few studies on telomere dynamics in animals. Studies on telomere dynamics and senescence in target tissues of animal strains used in toxicology are warranted. Cell culture studies on ionizing radiation have shown mixed results on telomere length, whereas both telomerase activity and cellular senescence are increased. Studies on persistent organic pollutants indicate telomere shortening, decreased telomerase activity and increased cellular senescence. Cell culture studies on heavy metals and air pollution particles are inconsistent. There is no coherent relationship between exposures, oxidative stress, telomere length, telomerase activity and cellular senescence in experimental studies on environmental or occupational exposures. This may be due to differences in exposure levels (including dose rate), exposure time and models (i.e. cell types and animal strains). Guidelines are needed for best practices on assays for telomere dynamics and cellular senescence in toxicology. However, it deserves notice that experimental studies in cells and animals have revealed important information on the effects of environmental and occupational agents on the maintenance of telomeres and cellular senescence.

AB - There has been a steady output of epidemiological studies linking environmental and occupational exposures to altered telomere length, showing mainly positive associations with persistent organic pollutants, inverse association with cadmium and inconsistent results with arsenic and lead. A bell-shaped dose-response relationship has been observed for ionizing radiation with telomere shortening at a low dose. Long-term air pollution is associated with telomere shortening, whereas the short-term exposure studies have shown mixed results. There are surprisingly few studies on telomere dynamics in animals. Studies on telomere dynamics and senescence in target tissues of animal strains used in toxicology are warranted. Cell culture studies on ionizing radiation have shown mixed results on telomere length, whereas both telomerase activity and cellular senescence are increased. Studies on persistent organic pollutants indicate telomere shortening, decreased telomerase activity and increased cellular senescence. Cell culture studies on heavy metals and air pollution particles are inconsistent. There is no coherent relationship between exposures, oxidative stress, telomere length, telomerase activity and cellular senescence in experimental studies on environmental or occupational exposures. This may be due to differences in exposure levels (including dose rate), exposure time and models (i.e. cell types and animal strains). Guidelines are needed for best practices on assays for telomere dynamics and cellular senescence in toxicology. However, it deserves notice that experimental studies in cells and animals have revealed important information on the effects of environmental and occupational agents on the maintenance of telomeres and cellular senescence.

U2 - 10.1080/10408444.2018.1538201

DO - 10.1080/10408444.2018.1538201

M3 - Journal article

VL - 48

SP - 761

EP - 788

JO - Critical Reviews in Toxicology

JF - Critical Reviews in Toxicology

SN - 1040-8444

IS - 9

ER -

ID: 210983255