A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population

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L T Dalgaard, Thomas Sørensen, T Drivsholm, K Borch-Johnsen, T Andersen, T Hansen, O Pedersen

Variability of the uncoupling protein 3 (UCP3) promoter has been associated with increased body mass index (BMI) and altered lipid profiles. Here we tested the hypothesis that variation of the UCP3 promoter is associated with either juvenile or maturity-onset obesity or body weight change over a 26-yr follow-up among Danish subjects. Mutation screening of approximately 1 kb 5' upstream of the UCP3 gene revealed one previously described -55 C-->T variant. The frequency of the polymorphism was evaluated by restriction fragment length polymorphism analysis in four groups of subjects: 1) a group of 744 obese Danish men who at the draft board examinations had a body mass index (BMI) of at least 31 kg/m(2), 2) a randomly selected control group consisting of 857 draftees, 3) 258 middle-aged subjects, and 4) 409 60-yr-old subjects. The frequency of the T allele was 26.0% (95% confidence interval, 23.8-28.2%) among the obese draftees and 26.9% (24.8-29.0%) in the control group (P = 0.6). The variant was not associated with BMI at a young age or with weight gain after a 26-yr follow-up. The frequency of the T allele was 29.5% (25.6-33.4%) in the middle-aged group and 25.8% (22.8-28.8%) among the 60-yr-old subjects. The polymorphism was not associated with increased BMI or percent body fat in these 2 groups. It is concluded that this variant does not play a major role in the development of common obesity among Danish subjects.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number3
Pages (from-to)1398-402
Number of pages5
ISSN0021-972X
Publication statusPublished - 1 Mar 2001

    Research areas

  • Adult, Alleles, Body Mass Index, Body Weight, Carrier Proteins, DNA Mutational Analysis, Denmark, Fatty Acids, Nonesterified, Female, Gene Frequency, Genotype, Homozygote, Humans, Ion Channels, Male, Middle Aged, Mitochondrial Proteins, Mutation, Obesity, Obesity, Morbid, Promoter Regions, Genetic

ID: 33030642