Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

Research output: Contribution to journalJournal articleResearchpeer-review

Kim Thomsen, Lars Christophersen, Peter Østrup Jensen, Thomas Bjarnsholt, Claus Moser, Niels Høiby

Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

Original languageEnglish
JournalHuman Vaccines & Immunotherapeutics
Volume12
Issue number7
Pages (from-to)1690-1699
Number of pages10
ISSN2164-5515
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • cystic fibrosis, IgY, phagocytosis, pseudomonas aeruginosa

ID: 168928477