Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting. / Nielsen, Malene Schjønning; Simonsen, Anja Hviid; Siersma, Volkert; Hasselbalch, Steen Gregers; Høgh, Peter.

In: Dementia and Geriatric Cognitive Disorders. Extra, Vol. 6, No. 3, 09.2016, p. 465-476.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, MS, Simonsen, AH, Siersma, V, Hasselbalch, SG & Høgh, P 2016, 'Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting', Dementia and Geriatric Cognitive Disorders. Extra, vol. 6, no. 3, pp. 465-476. https://doi.org/10.1159/000449410

APA

Nielsen, M. S., Simonsen, A. H., Siersma, V., Hasselbalch, S. G., & Høgh, P. (2016). Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting. Dementia and Geriatric Cognitive Disorders. Extra, 6(3), 465-476. https://doi.org/10.1159/000449410

Vancouver

Nielsen MS, Simonsen AH, Siersma V, Hasselbalch SG, Høgh P. Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting. Dementia and Geriatric Cognitive Disorders. Extra. 2016 Sep;6(3):465-476. https://doi.org/10.1159/000449410

Author

Nielsen, Malene Schjønning ; Simonsen, Anja Hviid ; Siersma, Volkert ; Hasselbalch, Steen Gregers ; Høgh, Peter. / Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting. In: Dementia and Geriatric Cognitive Disorders. Extra. 2016 ; Vol. 6, No. 3. pp. 465-476.

Bibtex

@article{59934ab8a70a43df8df451e8df273d80,
title = "Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting",
abstract = "BACKGROUND: Despite an extensive evaluation program, patients may remain diagnostically unresolved with regard to the etiology of their cognitive dysfunction. Cerebrospinal fluid neuroinflammation and Alzheimer disease (AD) biomarkers may act as indicators of neurodegenerative disorders in diagnostically unresolved patients.METHODS: Data on 348 patients were retrospectively evaluated. All participants had a standardized diagnostic workup and follow-up in a memory clinic.RESULTS: Aβ42 levels and Aβ42/p-tau ratios were reduced and levels of t-tau and p-tau as well as the t-tau × p-tau/Aβ42 ratio were elevated in diagnostically unresolved patients who clinically progressed, compared to a stable group. No differences in neuroinflammatory parameters were found.CONCLUSION: AD biomarkers - in particular the Aβ42/p-tau ratio, but not neuroinflammatory parameters - predicted clinical progression, regardless of etiology.",
keywords = "Journal Article",
author = "Nielsen, {Malene Schj{\o}nning} and Simonsen, {Anja Hviid} and Volkert Siersma and Hasselbalch, {Steen Gregers} and Peter H{\o}gh",
year = "2016",
month = "9",
doi = "10.1159/000449410",
language = "English",
volume = "6",
pages = "465--476",
journal = "Dementia and Geriatric Cognitive Disorders. Extra",
issn = "1664-5464",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting

AU - Nielsen, Malene Schjønning

AU - Simonsen, Anja Hviid

AU - Siersma, Volkert

AU - Hasselbalch, Steen Gregers

AU - Høgh, Peter

PY - 2016/9

Y1 - 2016/9

N2 - BACKGROUND: Despite an extensive evaluation program, patients may remain diagnostically unresolved with regard to the etiology of their cognitive dysfunction. Cerebrospinal fluid neuroinflammation and Alzheimer disease (AD) biomarkers may act as indicators of neurodegenerative disorders in diagnostically unresolved patients.METHODS: Data on 348 patients were retrospectively evaluated. All participants had a standardized diagnostic workup and follow-up in a memory clinic.RESULTS: Aβ42 levels and Aβ42/p-tau ratios were reduced and levels of t-tau and p-tau as well as the t-tau × p-tau/Aβ42 ratio were elevated in diagnostically unresolved patients who clinically progressed, compared to a stable group. No differences in neuroinflammatory parameters were found.CONCLUSION: AD biomarkers - in particular the Aβ42/p-tau ratio, but not neuroinflammatory parameters - predicted clinical progression, regardless of etiology.

AB - BACKGROUND: Despite an extensive evaluation program, patients may remain diagnostically unresolved with regard to the etiology of their cognitive dysfunction. Cerebrospinal fluid neuroinflammation and Alzheimer disease (AD) biomarkers may act as indicators of neurodegenerative disorders in diagnostically unresolved patients.METHODS: Data on 348 patients were retrospectively evaluated. All participants had a standardized diagnostic workup and follow-up in a memory clinic.RESULTS: Aβ42 levels and Aβ42/p-tau ratios were reduced and levels of t-tau and p-tau as well as the t-tau × p-tau/Aβ42 ratio were elevated in diagnostically unresolved patients who clinically progressed, compared to a stable group. No differences in neuroinflammatory parameters were found.CONCLUSION: AD biomarkers - in particular the Aβ42/p-tau ratio, but not neuroinflammatory parameters - predicted clinical progression, regardless of etiology.

KW - Journal Article

U2 - 10.1159/000449410

DO - 10.1159/000449410

M3 - Journal article

C2 - 27843444

VL - 6

SP - 465

EP - 476

JO - Dementia and Geriatric Cognitive Disorders. Extra

JF - Dementia and Geriatric Cognitive Disorders. Extra

SN - 1664-5464

IS - 3

ER -

ID: 176376740