Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?

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Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors? / Gade, Malene R; Goukasian, Irina; Panduro, Nathalie; Kamby, Claus; Nilas, Lisbeth; Tuxen, Malgorzata K; Bjerrum, Lars.

In: Post reproductive health, Vol. 24, No. 2, 06.2018, p. 67-71.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Gade, MR, Goukasian, I, Panduro, N, Kamby, C, Nilas, L, Tuxen, MK & Bjerrum, L 2018, 'Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?', Post reproductive health, vol. 24, no. 2, pp. 67-71. https://doi.org/10.1177/2053369118757545

APA

Gade, M. R., Goukasian, I., Panduro, N., Kamby, C., Nilas, L., Tuxen, M. K., & Bjerrum, L. (2018). Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors? Post reproductive health, 24(2), 67-71. https://doi.org/10.1177/2053369118757545

Vancouver

Gade MR, Goukasian I, Panduro N, Kamby C, Nilas L, Tuxen MK et al. Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors? Post reproductive health. 2018 Jun;24(2):67-71. https://doi.org/10.1177/2053369118757545

Author

Gade, Malene R ; Goukasian, Irina ; Panduro, Nathalie ; Kamby, Claus ; Nilas, Lisbeth ; Tuxen, Malgorzata K ; Bjerrum, Lars. / Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?. In: Post reproductive health. 2018 ; Vol. 24, No. 2. pp. 67-71.

Bibtex

@article{5e464e6d1c3745a78f06156646862f42,
title = "Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?",
abstract = "Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis. Multivariable logistic regression models were used to assess the association between vaginal symptoms and previous episodes of bacterial vaginosis. Results Moderate to severe symptoms due to vaginal itching/irritation were experienced by 6.4{\%} (95{\%} CI: 2.8-14.1{\%}), vaginal dryness by 28.4{\%} (95{\%} CI: 19.4-39.5{\%}), and dyspareunia by 23.1{\%} (95{\%} CI: 11.0-42.1{\%}). Patients with earlier episodes of bacterial vaginosis had an increased risk of vaginal dryness when exposed to a treatment with an aromatase inhibitor, adjusted OR 5.5 (95{\%} CI 1.3-21.6). Conclusion A considerable number of patients exposed to aromatase inhibitor have vaginal symptoms and the risk is highest among patients with earlier episodes of bacterial vaginosis.",
author = "Gade, {Malene R} and Irina Goukasian and Nathalie Panduro and Claus Kamby and Lisbeth Nilas and Tuxen, {Malgorzata K} and Lars Bjerrum",
year = "2018",
month = "6",
doi = "10.1177/2053369118757545",
language = "English",
volume = "24",
pages = "67--71",
journal = "Menopause International",
issn = "1754-0453",
publisher = "Royal Society of Medicine Press",
number = "2",

}

RIS

TY - JOUR

T1 - Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?

AU - Gade, Malene R

AU - Goukasian, Irina

AU - Panduro, Nathalie

AU - Kamby, Claus

AU - Nilas, Lisbeth

AU - Tuxen, Malgorzata K

AU - Bjerrum, Lars

PY - 2018/6

Y1 - 2018/6

N2 - Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis. Multivariable logistic regression models were used to assess the association between vaginal symptoms and previous episodes of bacterial vaginosis. Results Moderate to severe symptoms due to vaginal itching/irritation were experienced by 6.4% (95% CI: 2.8-14.1%), vaginal dryness by 28.4% (95% CI: 19.4-39.5%), and dyspareunia by 23.1% (95% CI: 11.0-42.1%). Patients with earlier episodes of bacterial vaginosis had an increased risk of vaginal dryness when exposed to a treatment with an aromatase inhibitor, adjusted OR 5.5 (95% CI 1.3-21.6). Conclusion A considerable number of patients exposed to aromatase inhibitor have vaginal symptoms and the risk is highest among patients with earlier episodes of bacterial vaginosis.

AB - Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis. Multivariable logistic regression models were used to assess the association between vaginal symptoms and previous episodes of bacterial vaginosis. Results Moderate to severe symptoms due to vaginal itching/irritation were experienced by 6.4% (95% CI: 2.8-14.1%), vaginal dryness by 28.4% (95% CI: 19.4-39.5%), and dyspareunia by 23.1% (95% CI: 11.0-42.1%). Patients with earlier episodes of bacterial vaginosis had an increased risk of vaginal dryness when exposed to a treatment with an aromatase inhibitor, adjusted OR 5.5 (95% CI 1.3-21.6). Conclusion A considerable number of patients exposed to aromatase inhibitor have vaginal symptoms and the risk is highest among patients with earlier episodes of bacterial vaginosis.

U2 - 10.1177/2053369118757545

DO - 10.1177/2053369118757545

M3 - Journal article

C2 - 29409388

VL - 24

SP - 67

EP - 71

JO - Menopause International

JF - Menopause International

SN - 1754-0453

IS - 2

ER -

ID: 198611308