Clinical indications for antibiotic use in Danish general practice: results from a nationwide electronic prescription database

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Clinical indications for antibiotic use in Danish general practice : results from a nationwide electronic prescription database. / Aabenhus, Rune; Hansen, Malene Plejdrup; Siersma, Volkert; Bjerrum, Lars.

In: Scandinavian Journal of Primary Health Care, Vol. 35, No. 2, 2017, p. 162-169.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Aabenhus, R, Hansen, MP, Siersma, V & Bjerrum, L 2017, 'Clinical indications for antibiotic use in Danish general practice: results from a nationwide electronic prescription database', Scandinavian Journal of Primary Health Care, vol. 35, no. 2, pp. 162-169. https://doi.org/10.1080/02813432.2017.1333321

APA

Aabenhus, R., Hansen, M. P., Siersma, V., & Bjerrum, L. (2017). Clinical indications for antibiotic use in Danish general practice: results from a nationwide electronic prescription database. Scandinavian Journal of Primary Health Care, 35(2), 162-169. https://doi.org/10.1080/02813432.2017.1333321

Vancouver

Aabenhus R, Hansen MP, Siersma V, Bjerrum L. Clinical indications for antibiotic use in Danish general practice: results from a nationwide electronic prescription database. Scandinavian Journal of Primary Health Care. 2017;35(2):162-169. https://doi.org/10.1080/02813432.2017.1333321

Author

Aabenhus, Rune ; Hansen, Malene Plejdrup ; Siersma, Volkert ; Bjerrum, Lars. / Clinical indications for antibiotic use in Danish general practice : results from a nationwide electronic prescription database. In: Scandinavian Journal of Primary Health Care. 2017 ; Vol. 35, No. 2. pp. 162-169.

Bibtex

@article{7a814a52aaae4383a7184b6aceb8d7eb,
title = "Clinical indications for antibiotic use in Danish general practice: results from a nationwide electronic prescription database",
abstract = "Objective: To assess the availability and applicability of clinical indications from electronic prescriptions on antibiotic use in Danish general practice.Design: Retrospective cohort register-based study including the Danish National Prescription Register.Setting: Population-based study of routine electronic antibiotic prescriptions from Danish general practice.Subjects: All 975,626 patients who redeemed an antibiotic prescription at outpatient pharmacies during the 1-year study period (July 2012 to June 2013).Main outcome measures: Number of prescriptions per clinical indication. Number of antibiotic prescriptions per 1000 inhabitants by age and gender. Logistic regression analysis estimated the association between patient and provider factors and missing clinical indications on antibiotic prescriptions.Results: A total of 2.381.083 systemic antibiotic prescriptions were issued by Danish general practitioners in the study period. We identified three main clinical entities: urinary tract infections (n = 506.634), respiratory tract infections (n = 456.354) and unspecified infections (n = 416.354). Women were more exposed to antibiotics than men. Antibiotic use was high in children under 5 years and even higher in elderly people. In 32{\%} of the issued prescriptions, the clinical indication was missing. This was mainly associated with antibiotic types. We found that a prescription for a urinary tract agent without a specific clinical indication was uncommon.Conclusion: Clinical indications from electronic prescriptions are accessible and available to provide an overview of drug use, in casu antibiotic prescriptions, in Danish general practice. These clinical indications may be further explored in detail to assess rational drug use and congruence with guidelines, but validation and optimisation of the system is preferable.",
keywords = "Antibiotic prescribing, clinical indication, general practice, electronic prescriptions, data linkage",
author = "Rune Aabenhus and Hansen, {Malene Plejdrup} and Volkert Siersma and Lars Bjerrum",
year = "2017",
doi = "10.1080/02813432.2017.1333321",
language = "English",
volume = "35",
pages = "162--169",
journal = "Scandinavian Journal of Primary Health Care",
issn = "0281-3432",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Clinical indications for antibiotic use in Danish general practice

T2 - results from a nationwide electronic prescription database

AU - Aabenhus, Rune

AU - Hansen, Malene Plejdrup

AU - Siersma, Volkert

AU - Bjerrum, Lars

PY - 2017

Y1 - 2017

N2 - Objective: To assess the availability and applicability of clinical indications from electronic prescriptions on antibiotic use in Danish general practice.Design: Retrospective cohort register-based study including the Danish National Prescription Register.Setting: Population-based study of routine electronic antibiotic prescriptions from Danish general practice.Subjects: All 975,626 patients who redeemed an antibiotic prescription at outpatient pharmacies during the 1-year study period (July 2012 to June 2013).Main outcome measures: Number of prescriptions per clinical indication. Number of antibiotic prescriptions per 1000 inhabitants by age and gender. Logistic regression analysis estimated the association between patient and provider factors and missing clinical indications on antibiotic prescriptions.Results: A total of 2.381.083 systemic antibiotic prescriptions were issued by Danish general practitioners in the study period. We identified three main clinical entities: urinary tract infections (n = 506.634), respiratory tract infections (n = 456.354) and unspecified infections (n = 416.354). Women were more exposed to antibiotics than men. Antibiotic use was high in children under 5 years and even higher in elderly people. In 32% of the issued prescriptions, the clinical indication was missing. This was mainly associated with antibiotic types. We found that a prescription for a urinary tract agent without a specific clinical indication was uncommon.Conclusion: Clinical indications from electronic prescriptions are accessible and available to provide an overview of drug use, in casu antibiotic prescriptions, in Danish general practice. These clinical indications may be further explored in detail to assess rational drug use and congruence with guidelines, but validation and optimisation of the system is preferable.

AB - Objective: To assess the availability and applicability of clinical indications from electronic prescriptions on antibiotic use in Danish general practice.Design: Retrospective cohort register-based study including the Danish National Prescription Register.Setting: Population-based study of routine electronic antibiotic prescriptions from Danish general practice.Subjects: All 975,626 patients who redeemed an antibiotic prescription at outpatient pharmacies during the 1-year study period (July 2012 to June 2013).Main outcome measures: Number of prescriptions per clinical indication. Number of antibiotic prescriptions per 1000 inhabitants by age and gender. Logistic regression analysis estimated the association between patient and provider factors and missing clinical indications on antibiotic prescriptions.Results: A total of 2.381.083 systemic antibiotic prescriptions were issued by Danish general practitioners in the study period. We identified three main clinical entities: urinary tract infections (n = 506.634), respiratory tract infections (n = 456.354) and unspecified infections (n = 416.354). Women were more exposed to antibiotics than men. Antibiotic use was high in children under 5 years and even higher in elderly people. In 32% of the issued prescriptions, the clinical indication was missing. This was mainly associated with antibiotic types. We found that a prescription for a urinary tract agent without a specific clinical indication was uncommon.Conclusion: Clinical indications from electronic prescriptions are accessible and available to provide an overview of drug use, in casu antibiotic prescriptions, in Danish general practice. These clinical indications may be further explored in detail to assess rational drug use and congruence with guidelines, but validation and optimisation of the system is preferable.

KW - Antibiotic prescribing

KW - clinical indication

KW - general practice

KW - electronic prescriptions

KW - data linkage

U2 - 10.1080/02813432.2017.1333321

DO - 10.1080/02813432.2017.1333321

M3 - Journal article

VL - 35

SP - 162

EP - 169

JO - Scandinavian Journal of Primary Health Care

JF - Scandinavian Journal of Primary Health Care

SN - 0281-3432

IS - 2

ER -

ID: 186996136