Electrocardiographic PR Interval Duration and Cardiovascular Risk: Results From the Copenhagen ECG Study

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Background Because of ambiguous reports in the literature, we aimed to investigate the association between PR interval and the risk of all-cause and cardiovascular death, heart failure, and pacemaker implantation, allowing for a nonlinear relationship. MethodsWe included 293,111 individuals, corresponding to one-third of the population in the greater region of Copenhagen. These individuals had a digital electrocardiogram recorded in a general practitioner's core facility from 2001-2011. Data on drug use, comorbidities, and outcomes were collected from Danish registries. We divided the population into 7 groups based on the population PR interval distribution. Cox models were used, with reference to a PR interval between 152 and 161 ms (40th to < 60th percentile). ResultsDuring follow-up, we identified 34,783 deaths from all causes, 9867 cardiovascular deaths, 9526 cases of incident heart failure, and 1805 pacemaker implantations. A short PR interval ( <125 ( , 1.08-1.41; 1.23; 95% [ci] [hr], a as confidence hazard interval long ms; p ="0.001)" pr ratio well> 200 ms; HR, 1.23; 95% CI, 1.14-1.32; P <0.001) ( a adjustment. after an associated cardiovascular conferred death failure heart increased interval long multivariable of pr risk was with> 200 ms; HR, 1.31; 95% CI, 1.22-1.42; P <0.001). a an associated conferred dose-response highest implantation, in increased increasing interval manner, of pacemaker pr risk the with> 200 ms (HR, 3.49; 95% CI, 2.96-4.11; P < 0.001). Conclusions PR interval was significantly associated with the risk of the adverse outcomes investigated. The nonlinear relationships, in combination with relatively weak associations, could contribute to previously reported conflicting results on the subject.
Original languageEnglish
JournalCanadian Journal of Cardiology
Issue number5
Pages (from-to)674-681
Number of pages8
Publication statusPublished - May 2017

ID: 189734184