ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Research output: Contribution to journalJournal articleResearchpeer-review


Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.

Original languageEnglish
JournalCell Reports
Issue number9
Pages (from-to)2756-2769.e6
Number of pages21
Publication statusPublished - 26 Nov 2019

    Research areas

  • B cell development, ERG, ETS-related gene, immunoglobulin heavy-chain gene, pre-BCR, transcriptional control, V(D)J recombination

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 231505814