Ibuprofen versus mecillinam for uncomplicated cystitis - a randomized controlled trial study protocol

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Ingvild Vik, Marianne Bollestad, Nils Grude, Anders Bærheim, Sigvard Mölstad, Lars Bjerrum, Morten Lindbæk

BackgroundAlthough uncomplicated cystitis is often self-limiting, most such patients will be prescribed antibiotic treatment. We are investigating whether treatment of cystitis with an NSAID is as effective as an antibiotic in achieving symptomatic resolution.Methods/DesignThis is a randomized, controlled, double blind trial following the principles of Good Clinical Practice. Women between the ages of 18 to 60 presenting with symptoms of uncomplicated cystitis are screened for eligibility. 500 women from four sites in Norway, Sweden and Denmark are allocated to treatment with 600 mg ibuprofen three times a day or 200 mg mecillinam three times a day for three days. Allocation is conducted using block randomization. The primary outcome is the number of patients who feel cured by day four as recorded in a diary. Adverse events will be handled and reported in accordance with Good Clinical Practice.DiscussionIf treatment of uncomplicated cystitis with ibuprofen is as effective as mecillinam for symptom relief, we can potentially reduce the use of antibiotics on a global scale.Trial registrationEudraCTnr: 2012-002776-14. ClinicalTrials.gov: NCT01849926.

Original languageEnglish
Article number693
JournalB M C Infectious Diseases
Volume14
Pages (from-to)1-6
Number of pages6
ISSN1471-2334
DOIs
Publication statusPublished - 17 Dec 2014

ID: 129144087