Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion

Research output: Contribution to journalJournal articleResearchpeer-review

  • A Johansen
  • E-M D Nielsen
  • G Andersen
  • Y H Hamid
  • D P Jensen
  • C Glümer
  • Drivsholm, Thomas
  • K Borch-Johnsen
  • T Jørgensen
  • T Hansen
  • O Pedersen
Polymorphisms of the butyrylcholinesterase gene (BCHE) are reported to associate with Alzheimer's disease and a recent study found a significant association of the BCHE K variant (G1615A/Ala539Thr) with Type 2 diabetes. The objectives of our study were to examine whether the BCHE K variant is associated with Type 2 diabetes or estimates of pancreatic beta cell function in large-scale populations of glucose-tolerant Caucasians.
Original languageEnglish
Issue number8
Pages (from-to)1437-41
Number of pages5
Publication statusPublished - 1 Aug 2004

    Research areas

  • Amino Acid Substitution, Base Sequence, Blood Glucose, Butyrylcholinesterase, DNA Primers, Diabetes Mellitus, Type 2, Gene Frequency, Genetic Variation, Genotype, Humans, Insulin, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Reference Values

ID: 33030584