Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients

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Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients. / Jorgensen, Anders; Siersma, Volkert; Davidsen, Annette S.; Weimann, Allan; Henriksen, Trine; Poulsen, Henrik E.; Olivarius, Niels de Fine.

In: Psychiatry Research, Vol. 259, 01.2018, p. 370-376.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jorgensen, A, Siersma, V, Davidsen, AS, Weimann, A, Henriksen, T, Poulsen, HE & Olivarius, NDF 2018, 'Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients', Psychiatry Research, vol. 259, pp. 370-376. https://doi.org/10.1016/j.psychres.2017.11.017

APA

Jorgensen, A., Siersma, V., Davidsen, A. S., Weimann, A., Henriksen, T., Poulsen, H. E., & Olivarius, N. D. F. (2018). Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients. Psychiatry Research, 259, 370-376. https://doi.org/10.1016/j.psychres.2017.11.017

Vancouver

Jorgensen A, Siersma V, Davidsen AS, Weimann A, Henriksen T, Poulsen HE et al. Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients. Psychiatry Research. 2018 Jan;259:370-376. https://doi.org/10.1016/j.psychres.2017.11.017

Author

Jorgensen, Anders ; Siersma, Volkert ; Davidsen, Annette S. ; Weimann, Allan ; Henriksen, Trine ; Poulsen, Henrik E. ; Olivarius, Niels de Fine. / Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients. In: Psychiatry Research. 2018 ; Vol. 259. pp. 370-376.

Bibtex

@article{4213462b84524a3c9d09e7e57f551f68,
title = "Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients",
abstract = "Oxidative stress is a potential biological mediator of the higher rates of psychiatric illness (PI) observed after the onset of type 2 diabetes (T2DM). We investigated validated urinary markers of systemic DNA/RNA damage from oxidation (8-oxodG/8-oxoGuo respectively) as predictors of incident PI in a cohort of 1381 newly diagnosed T2DM patients, who were followed prospectively for a total of 19 years after diagnosis. Psychiatric diagnoses were from Danish national registries. Patients were examined at the time of diagnosis and at a 6-year follow-up. At baseline, 8-oxodG was slightly lower in PI vs. non-PI patients, while at 6-year follow-up, 8-oxoGuo was significantly higher in PI patients. Using Cox proportional hazard models, we found that higher levels of 8-oxodG at 6-year follow-up significantly predicted lower incidence of PI after the adjustment for confounders. In a subgroup analysis, this association was most predominant in minor PIs (unipolar depression and anxiety) compared to major PIs such as schizophrenia and bipolar disorder. These observations indicate that higher levels of systemic oxidative stress are not associated with a higher risk of PI after T2DM onset. Only PI patients treated in hospital care were included in the registries, and the conclusion thus only applies to these individuals.",
keywords = "Journal Article",
author = "Anders Jorgensen and Volkert Siersma and Davidsen, {Annette S.} and Allan Weimann and Trine Henriksen and Poulsen, {Henrik E.} and Olivarius, {Niels de Fine}",
note = "Copyright {\circledC} 2017. Published by Elsevier B.V.",
year = "2018",
month = "1",
doi = "10.1016/j.psychres.2017.11.017",
language = "English",
volume = "259",
pages = "370--376",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Markers of DNA/RNA damage from oxidation as predictors of a registry-based diagnosis of psychiatric illness in type 2 diabetic patients

AU - Jorgensen, Anders

AU - Siersma, Volkert

AU - Davidsen, Annette S.

AU - Weimann, Allan

AU - Henriksen, Trine

AU - Poulsen, Henrik E.

AU - Olivarius, Niels de Fine

N1 - Copyright © 2017. Published by Elsevier B.V.

PY - 2018/1

Y1 - 2018/1

N2 - Oxidative stress is a potential biological mediator of the higher rates of psychiatric illness (PI) observed after the onset of type 2 diabetes (T2DM). We investigated validated urinary markers of systemic DNA/RNA damage from oxidation (8-oxodG/8-oxoGuo respectively) as predictors of incident PI in a cohort of 1381 newly diagnosed T2DM patients, who were followed prospectively for a total of 19 years after diagnosis. Psychiatric diagnoses were from Danish national registries. Patients were examined at the time of diagnosis and at a 6-year follow-up. At baseline, 8-oxodG was slightly lower in PI vs. non-PI patients, while at 6-year follow-up, 8-oxoGuo was significantly higher in PI patients. Using Cox proportional hazard models, we found that higher levels of 8-oxodG at 6-year follow-up significantly predicted lower incidence of PI after the adjustment for confounders. In a subgroup analysis, this association was most predominant in minor PIs (unipolar depression and anxiety) compared to major PIs such as schizophrenia and bipolar disorder. These observations indicate that higher levels of systemic oxidative stress are not associated with a higher risk of PI after T2DM onset. Only PI patients treated in hospital care were included in the registries, and the conclusion thus only applies to these individuals.

AB - Oxidative stress is a potential biological mediator of the higher rates of psychiatric illness (PI) observed after the onset of type 2 diabetes (T2DM). We investigated validated urinary markers of systemic DNA/RNA damage from oxidation (8-oxodG/8-oxoGuo respectively) as predictors of incident PI in a cohort of 1381 newly diagnosed T2DM patients, who were followed prospectively for a total of 19 years after diagnosis. Psychiatric diagnoses were from Danish national registries. Patients were examined at the time of diagnosis and at a 6-year follow-up. At baseline, 8-oxodG was slightly lower in PI vs. non-PI patients, while at 6-year follow-up, 8-oxoGuo was significantly higher in PI patients. Using Cox proportional hazard models, we found that higher levels of 8-oxodG at 6-year follow-up significantly predicted lower incidence of PI after the adjustment for confounders. In a subgroup analysis, this association was most predominant in minor PIs (unipolar depression and anxiety) compared to major PIs such as schizophrenia and bipolar disorder. These observations indicate that higher levels of systemic oxidative stress are not associated with a higher risk of PI after T2DM onset. Only PI patients treated in hospital care were included in the registries, and the conclusion thus only applies to these individuals.

KW - Journal Article

U2 - 10.1016/j.psychres.2017.11.017

DO - 10.1016/j.psychres.2017.11.017

M3 - Journal article

C2 - 29120845

VL - 259

SP - 370

EP - 376

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -

ID: 185848874