Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study

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Precursors of age-related macular degeneration : associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study. / Munch, Inger Christine; Toft, Ulla; Linneberg, Allan; Larsen, Michael.

In: Acta Ophthalmologica, Vol. 94, No. 7, 11.2016, p. 657-662.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Munch, IC, Toft, U, Linneberg, A & Larsen, M 2016, 'Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study', Acta Ophthalmologica, vol. 94, no. 7, pp. 657-662. https://doi.org/10.1111/aos.13198

APA

Munch, I. C., Toft, U., Linneberg, A., & Larsen, M. (2016). Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study. Acta Ophthalmologica, 94(7), 657-662. https://doi.org/10.1111/aos.13198

Vancouver

Munch IC, Toft U, Linneberg A, Larsen M. Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study. Acta Ophthalmologica. 2016 Nov;94(7):657-662. https://doi.org/10.1111/aos.13198

Author

Munch, Inger Christine ; Toft, Ulla ; Linneberg, Allan ; Larsen, Michael. / Precursors of age-related macular degeneration : associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study. In: Acta Ophthalmologica. 2016 ; Vol. 94, No. 7. pp. 657-662.

Bibtex

@article{a67dc482d0c64a389a918d3046238056,
title = "Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study",
abstract = "PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.",
keywords = "Adult, Complement Factor H, Cross-Sectional Studies, Diet, Female, Humans, Macular Degeneration, Male, Middle Aged, Polymorphism, Single Nucleotide, Proteins, Retinal Drusen, Risk Factors, Visual Acuity, Vitamin A, Vitamins, Journal Article, Randomized Controlled Trial",
author = "Munch, {Inger Christine} and Ulla Toft and Allan Linneberg and Michael Larsen",
note = "{\circledC} 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",
year = "2016",
month = "11",
doi = "10.1111/aos.13198",
language = "English",
volume = "94",
pages = "657--662",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Precursors of age-related macular degeneration

T2 - associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study

AU - Munch, Inger Christine

AU - Toft, Ulla

AU - Linneberg, Allan

AU - Larsen, Michael

N1 - © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

PY - 2016/11

Y1 - 2016/11

N2 - PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.

AB - PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.

KW - Adult

KW - Complement Factor H

KW - Cross-Sectional Studies

KW - Diet

KW - Female

KW - Humans

KW - Macular Degeneration

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Proteins

KW - Retinal Drusen

KW - Risk Factors

KW - Visual Acuity

KW - Vitamin A

KW - Vitamins

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1111/aos.13198

DO - 10.1111/aos.13198

M3 - Journal article

C2 - 27502478

VL - 94

SP - 657

EP - 662

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 7

ER -

ID: 173095092