Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes

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Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. / Broedbaek, Kasper; Siersma, Volkert; Henriksen, Trine Foged; Weimann, Allan; Petersen, Morten; Andersen, Jon T.; Solem, Espen Victor Jimenez; Hansen, Lars J; Henriksen, Jan Erik; Bonnema, Steen J; de Fine Olivarius, Niels; Friis, Søren; Poulsen, Henrik E.

In: Redox Biology, Vol. 4, 04.2015, p. 34-39.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Broedbaek, K, Siersma, V, Henriksen, TF, Weimann, A, Petersen, M, Andersen, JT, Solem, EVJ, Hansen, LJ, Henriksen, JE, Bonnema, SJ, de Fine Olivarius, N, Friis, S & Poulsen, HE 2015, 'Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes', Redox Biology, vol. 4, pp. 34-39. https://doi.org/10.1016/j.redox.2014.11.010

APA

Broedbaek, K., Siersma, V., Henriksen, T. F., Weimann, A., Petersen, M., Andersen, J. T., ... Poulsen, H. E. (2015). Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. Redox Biology, 4, 34-39. https://doi.org/10.1016/j.redox.2014.11.010

Vancouver

Broedbaek K, Siersma V, Henriksen TF, Weimann A, Petersen M, Andersen JT et al. Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. Redox Biology. 2015 Apr;4:34-39. https://doi.org/10.1016/j.redox.2014.11.010

Author

Broedbaek, Kasper ; Siersma, Volkert ; Henriksen, Trine Foged ; Weimann, Allan ; Petersen, Morten ; Andersen, Jon T. ; Solem, Espen Victor Jimenez ; Hansen, Lars J ; Henriksen, Jan Erik ; Bonnema, Steen J ; de Fine Olivarius, Niels ; Friis, Søren ; Poulsen, Henrik E. / Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes. In: Redox Biology. 2015 ; Vol. 4. pp. 34-39.

Bibtex

@article{784df43f2e314128aa40386e0f97be90,
title = "Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes",
abstract = "AIMS/HYPOTHESIS: We investigated whether urinary markers of nucleic acid oxidation are associated with an increased risk of cancer in type 2 diabetes patients.METHODS: Urine samples from 1381 newly diagnosed diabetes patients were assayed for the oxidatively modified guanine nucleosides 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo). Cox proportional hazards regression was used to examine the relationship between the urinary markers and cancer incidence.RESULTS: The crude analyses showed an association between overall cancer and urinary excretion of the RNA oxidation marker 8-oxoGuo (unadjusted hazard ratio for cancer per natural log increase in 8-oxoGuo 1.35 [95{\%} CI, 1.01-1.81]), however, in the adjusted analyses, no significant associations between 8-oxodG or 8-oxoGuo and overall cancer were found. For site-specific cancers 8-oxodG was associated with breast cancer in the crude analyses (unadjusted hazard ratio for breast cancer per natural log increase in 8-oxodG was 2.37 [95{\%} CI, 1.07-5.26]), although the association was attenuated in the adjusted analyses (sex- and age-adjusted hazard ratio 2.15 [95{\%} CI, 0.92-5.02] and multivariate adjusted hazard ratio1.98 [95{\%} CI, 0.95-4.10]).CONCLUSIONS: Urinary excretion of the nucleic acid oxidation markers 8-oxodG and 8-oxoGuo at the time of diagnosis was not associated with cancer overall in type 2 diabetes patients. For site-specific cancers, risk elevations were seen for breast cancer (8-oxodG). These findings should be examined in future and larger studies.",
author = "Kasper Broedbaek and Volkert Siersma and Henriksen, {Trine Foged} and Allan Weimann and Morten Petersen and Andersen, {Jon T.} and Solem, {Espen Victor Jimenez} and Hansen, {Lars J} and Henriksen, {Jan Erik} and Bonnema, {Steen J} and {de Fine Olivarius}, Niels and S{\o}ren Friis and Poulsen, {Henrik E}",
note = "Copyright {\circledC} 2014 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2015",
month = "4",
doi = "10.1016/j.redox.2014.11.010",
language = "English",
volume = "4",
pages = "34--39",
journal = "Redox Biology",
issn = "2213-2317",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes

AU - Broedbaek, Kasper

AU - Siersma, Volkert

AU - Henriksen, Trine Foged

AU - Weimann, Allan

AU - Petersen, Morten

AU - Andersen, Jon T.

AU - Solem, Espen Victor Jimenez

AU - Hansen, Lars J

AU - Henriksen, Jan Erik

AU - Bonnema, Steen J

AU - de Fine Olivarius, Niels

AU - Friis, Søren

AU - Poulsen, Henrik E

N1 - Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2015/4

Y1 - 2015/4

N2 - AIMS/HYPOTHESIS: We investigated whether urinary markers of nucleic acid oxidation are associated with an increased risk of cancer in type 2 diabetes patients.METHODS: Urine samples from 1381 newly diagnosed diabetes patients were assayed for the oxidatively modified guanine nucleosides 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo). Cox proportional hazards regression was used to examine the relationship between the urinary markers and cancer incidence.RESULTS: The crude analyses showed an association between overall cancer and urinary excretion of the RNA oxidation marker 8-oxoGuo (unadjusted hazard ratio for cancer per natural log increase in 8-oxoGuo 1.35 [95% CI, 1.01-1.81]), however, in the adjusted analyses, no significant associations between 8-oxodG or 8-oxoGuo and overall cancer were found. For site-specific cancers 8-oxodG was associated with breast cancer in the crude analyses (unadjusted hazard ratio for breast cancer per natural log increase in 8-oxodG was 2.37 [95% CI, 1.07-5.26]), although the association was attenuated in the adjusted analyses (sex- and age-adjusted hazard ratio 2.15 [95% CI, 0.92-5.02] and multivariate adjusted hazard ratio1.98 [95% CI, 0.95-4.10]).CONCLUSIONS: Urinary excretion of the nucleic acid oxidation markers 8-oxodG and 8-oxoGuo at the time of diagnosis was not associated with cancer overall in type 2 diabetes patients. For site-specific cancers, risk elevations were seen for breast cancer (8-oxodG). These findings should be examined in future and larger studies.

AB - AIMS/HYPOTHESIS: We investigated whether urinary markers of nucleic acid oxidation are associated with an increased risk of cancer in type 2 diabetes patients.METHODS: Urine samples from 1381 newly diagnosed diabetes patients were assayed for the oxidatively modified guanine nucleosides 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo). Cox proportional hazards regression was used to examine the relationship between the urinary markers and cancer incidence.RESULTS: The crude analyses showed an association between overall cancer and urinary excretion of the RNA oxidation marker 8-oxoGuo (unadjusted hazard ratio for cancer per natural log increase in 8-oxoGuo 1.35 [95% CI, 1.01-1.81]), however, in the adjusted analyses, no significant associations between 8-oxodG or 8-oxoGuo and overall cancer were found. For site-specific cancers 8-oxodG was associated with breast cancer in the crude analyses (unadjusted hazard ratio for breast cancer per natural log increase in 8-oxodG was 2.37 [95% CI, 1.07-5.26]), although the association was attenuated in the adjusted analyses (sex- and age-adjusted hazard ratio 2.15 [95% CI, 0.92-5.02] and multivariate adjusted hazard ratio1.98 [95% CI, 0.95-4.10]).CONCLUSIONS: Urinary excretion of the nucleic acid oxidation markers 8-oxodG and 8-oxoGuo at the time of diagnosis was not associated with cancer overall in type 2 diabetes patients. For site-specific cancers, risk elevations were seen for breast cancer (8-oxodG). These findings should be examined in future and larger studies.

U2 - 10.1016/j.redox.2014.11.010

DO - 10.1016/j.redox.2014.11.010

M3 - Journal article

C2 - 25498965

VL - 4

SP - 34

EP - 39

JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

ER -

ID: 137421543