Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference

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Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference. / Ankarfeldt, Mikkel Zøllner; Larsen, Sofus C; Ängquist, Lars; Husemoen, Lise Lotte Nystrup; Roswall, Nina; Overvad, Kim; Jakobsen, Marianne Uhre; Halkjær, Jytte; Tjønneland, Anne; Linneberg, Allan; Toft, Ulla; Hansen, Torben; Pedersen, Oluf; Heitmann, Berit L; Astrup, Arne; Sørensen, Thorkild I.A.

In: P L o S One, Vol. 9, No. 10, e110890, 2014.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ankarfeldt, MZ, Larsen, SC, Ängquist, L, Husemoen, LLN, Roswall, N, Overvad, K, Jakobsen, MU, Halkjær, J, Tjønneland, A, Linneberg, A, Toft, U, Hansen, T, Pedersen, O, Heitmann, BL, Astrup, A & Sørensen, TIA 2014, 'Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference', P L o S One, vol. 9, no. 10, e110890. https://doi.org/10.1371/journal.pone.0110890

APA

Ankarfeldt, M. Z., Larsen, S. C., Ängquist, L., Husemoen, L. L. N., Roswall, N., Overvad, K., ... Sørensen, T. I. A. (2014). Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference. P L o S One, 9(10), [e110890]. https://doi.org/10.1371/journal.pone.0110890

Vancouver

Ankarfeldt MZ, Larsen SC, Ängquist L, Husemoen LLN, Roswall N, Overvad K et al. Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference. P L o S One. 2014;9(10). e110890. https://doi.org/10.1371/journal.pone.0110890

Author

Ankarfeldt, Mikkel Zøllner ; Larsen, Sofus C ; Ängquist, Lars ; Husemoen, Lise Lotte Nystrup ; Roswall, Nina ; Overvad, Kim ; Jakobsen, Marianne Uhre ; Halkjær, Jytte ; Tjønneland, Anne ; Linneberg, Allan ; Toft, Ulla ; Hansen, Torben ; Pedersen, Oluf ; Heitmann, Berit L ; Astrup, Arne ; Sørensen, Thorkild I.A. / Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference. In: P L o S One. 2014 ; Vol. 9, No. 10.

Bibtex

@article{d16e0a2a7caf4ea6ab1ac31f67b36e30,
title = "Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference",
abstract = "BACKGROUND: Genetic predisposition to adiposity may interact with dietary protein in relation to changes of anthropometry.OBJECTIVE: To investigate the interaction between genetic predisposition to higher body mass index (BMI), waist circumference (WC) or waist-hip ratio adjusted for BMI (WHRBMI) and dietary protein in relation to subsequent change in body weight (ΔBW) or change in WC (ΔWC).DESIGN: Three different Danish cohorts were used. In total 7,054 individuals constituted the study population with information on diet, 50 single-nucleotide polymorphisms (SNPs) associated with BMI, WC or WHRBMI, as well as potential confounders. Mean follow-up time was ∼5 years. Four genetic predisposition-scores were based on the SNPs; a complete-score including all selected adiposity- associated SNPs, and three scores including BMI, WC or WHRBMI associated polymorphisms, respectively. The association between protein intake and ΔBW or ΔWC were examined and interactions between SNP-score and protein were investigated. Analyses were based on linear regressions using macronutrient substitution models and meta-analyses.RESULTS: When protein replaced carbohydrate, meta-analyses showed no associations with ΔBW (41.0 gram/y/5 energy{\%} protein, [95{\%} CI: -32.3; 114.3]) or ΔWC (<-0.1 mm/y/5 energy {\%} protein, [-1.1; 1.1]). Similarly, there were no interactions for any SNP-scores and protein for either ΔBW (complete SNP-score: 1.8 gram/y/5 energy{\%} protein/risk allele, [-7.0; 10.6]) or ΔWC (complete SNP-score: <0.1 mm/y/5 energy{\%} protein/risk allele, [-0.1; 0.1]). Similar results were seen when protein replaced fat.CONCLUSION: This study indicates that the genetic predisposition to general and abdominal adiposity, assessed by gene-scores, does not seem to modulate the influence of dietary protein on ΔBW or ΔWC.",
author = "Ankarfeldt, {Mikkel Z{\o}llner} and Larsen, {Sofus C} and Lars {\"A}ngquist and Husemoen, {Lise Lotte Nystrup} and Nina Roswall and Kim Overvad and Jakobsen, {Marianne Uhre} and Jytte Halkj{\ae}r and Anne Tj{\o}nneland and Allan Linneberg and Ulla Toft and Torben Hansen and Oluf Pedersen and Heitmann, {Berit L} and Arne Astrup and S{\o}rensen, {Thorkild I.A.}",
note = "CURIS 2014 NEXS 318",
year = "2014",
doi = "10.1371/journal.pone.0110890",
language = "English",
volume = "9",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference

AU - Ankarfeldt, Mikkel Zøllner

AU - Larsen, Sofus C

AU - Ängquist, Lars

AU - Husemoen, Lise Lotte Nystrup

AU - Roswall, Nina

AU - Overvad, Kim

AU - Jakobsen, Marianne Uhre

AU - Halkjær, Jytte

AU - Tjønneland, Anne

AU - Linneberg, Allan

AU - Toft, Ulla

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Heitmann, Berit L

AU - Astrup, Arne

AU - Sørensen, Thorkild I.A.

N1 - CURIS 2014 NEXS 318

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Genetic predisposition to adiposity may interact with dietary protein in relation to changes of anthropometry.OBJECTIVE: To investigate the interaction between genetic predisposition to higher body mass index (BMI), waist circumference (WC) or waist-hip ratio adjusted for BMI (WHRBMI) and dietary protein in relation to subsequent change in body weight (ΔBW) or change in WC (ΔWC).DESIGN: Three different Danish cohorts were used. In total 7,054 individuals constituted the study population with information on diet, 50 single-nucleotide polymorphisms (SNPs) associated with BMI, WC or WHRBMI, as well as potential confounders. Mean follow-up time was ∼5 years. Four genetic predisposition-scores were based on the SNPs; a complete-score including all selected adiposity- associated SNPs, and three scores including BMI, WC or WHRBMI associated polymorphisms, respectively. The association between protein intake and ΔBW or ΔWC were examined and interactions between SNP-score and protein were investigated. Analyses were based on linear regressions using macronutrient substitution models and meta-analyses.RESULTS: When protein replaced carbohydrate, meta-analyses showed no associations with ΔBW (41.0 gram/y/5 energy% protein, [95% CI: -32.3; 114.3]) or ΔWC (<-0.1 mm/y/5 energy % protein, [-1.1; 1.1]). Similarly, there were no interactions for any SNP-scores and protein for either ΔBW (complete SNP-score: 1.8 gram/y/5 energy% protein/risk allele, [-7.0; 10.6]) or ΔWC (complete SNP-score: <0.1 mm/y/5 energy% protein/risk allele, [-0.1; 0.1]). Similar results were seen when protein replaced fat.CONCLUSION: This study indicates that the genetic predisposition to general and abdominal adiposity, assessed by gene-scores, does not seem to modulate the influence of dietary protein on ΔBW or ΔWC.

AB - BACKGROUND: Genetic predisposition to adiposity may interact with dietary protein in relation to changes of anthropometry.OBJECTIVE: To investigate the interaction between genetic predisposition to higher body mass index (BMI), waist circumference (WC) or waist-hip ratio adjusted for BMI (WHRBMI) and dietary protein in relation to subsequent change in body weight (ΔBW) or change in WC (ΔWC).DESIGN: Three different Danish cohorts were used. In total 7,054 individuals constituted the study population with information on diet, 50 single-nucleotide polymorphisms (SNPs) associated with BMI, WC or WHRBMI, as well as potential confounders. Mean follow-up time was ∼5 years. Four genetic predisposition-scores were based on the SNPs; a complete-score including all selected adiposity- associated SNPs, and three scores including BMI, WC or WHRBMI associated polymorphisms, respectively. The association between protein intake and ΔBW or ΔWC were examined and interactions between SNP-score and protein were investigated. Analyses were based on linear regressions using macronutrient substitution models and meta-analyses.RESULTS: When protein replaced carbohydrate, meta-analyses showed no associations with ΔBW (41.0 gram/y/5 energy% protein, [95% CI: -32.3; 114.3]) or ΔWC (<-0.1 mm/y/5 energy % protein, [-1.1; 1.1]). Similarly, there were no interactions for any SNP-scores and protein for either ΔBW (complete SNP-score: 1.8 gram/y/5 energy% protein/risk allele, [-7.0; 10.6]) or ΔWC (complete SNP-score: <0.1 mm/y/5 energy% protein/risk allele, [-0.1; 0.1]). Similar results were seen when protein replaced fat.CONCLUSION: This study indicates that the genetic predisposition to general and abdominal adiposity, assessed by gene-scores, does not seem to modulate the influence of dietary protein on ΔBW or ΔWC.

U2 - 10.1371/journal.pone.0110890

DO - 10.1371/journal.pone.0110890

M3 - Journal article

VL - 9

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 10

M1 - e110890

ER -

ID: 126172434