Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression

Research output: Contribution to journalJournal articleResearchpeer-review

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Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. / Gardiner, S. L.; van Belzen, M. J.; Boogaard, M. W.; van Roon-Mom, W. M. C.; Rozing, M. P.; van Hemert, A. M.; Smit, J. H.; Beekman, A. T. F.; van Grootheest, G.; Schoevers, R. A.; Voshaar, R. C. Oude; Comijs, H. C.; Penninx, B. W. J. H.; van der Mast, R. C.; Roos, R. A. C.; Aziz, N. A.

In: Translational Psychiatry, Vol. 7, e1143, 06.06.2017, p. 1-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Gardiner, SL, van Belzen, MJ, Boogaard, MW, van Roon-Mom, WMC, Rozing, MP, van Hemert, AM, Smit, JH, Beekman, ATF, van Grootheest, G, Schoevers, RA, Voshaar, RCO, Comijs, HC, Penninx, BWJH, van der Mast, RC, Roos, RAC & Aziz, NA 2017, 'Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression', Translational Psychiatry, vol. 7, e1143, pp. 1-7. https://doi.org/10.1038/tp.2017.116

APA

Gardiner, S. L., van Belzen, M. J., Boogaard, M. W., van Roon-Mom, W. M. C., Rozing, M. P., van Hemert, A. M., ... Aziz, N. A. (2017). Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. Translational Psychiatry, 7, 1-7. [e1143]. https://doi.org/10.1038/tp.2017.116

Vancouver

Gardiner SL, van Belzen MJ, Boogaard MW, van Roon-Mom WMC, Rozing MP, van Hemert AM et al. Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. Translational Psychiatry. 2017 Jun 6;7:1-7. e1143. https://doi.org/10.1038/tp.2017.116

Author

Gardiner, S. L. ; van Belzen, M. J. ; Boogaard, M. W. ; van Roon-Mom, W. M. C. ; Rozing, M. P. ; van Hemert, A. M. ; Smit, J. H. ; Beekman, A. T. F. ; van Grootheest, G. ; Schoevers, R. A. ; Voshaar, R. C. Oude ; Comijs, H. C. ; Penninx, B. W. J. H. ; van der Mast, R. C. ; Roos, R. A. C. ; Aziz, N. A. / Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression. In: Translational Psychiatry. 2017 ; Vol. 7. pp. 1-7.

Bibtex

@article{9e8ff5f2fd1a41789a0fe02a6d90d99d,
title = "Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression",
abstract = "Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine–adenine–guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts—the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons—including 2165 depressed and 1058 non-depressed individuals—aged 18–93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with ≤10, CAG repeats in both ATXN7 alleles (OR=1.90, confidence interval (CI) 1.26–2.85). For TBP we found a similar association: A CAG repeat length exceeding the median in both alleles was associated with an increased risk for lifetime depression (OR=1.33, CI 1.00–1.76). In conclusion, we observed that carriers of either ATXN7 or TBP alleles with relatively large CAG repeat sizes in both alleles had a substantially increased risk of lifetime depression. Our findings provide critical evidence for the notion that repeat polymorphisms can act as complex genetic modifiers of depression.",
author = "Gardiner, {S. L.} and {van Belzen}, {M. J.} and Boogaard, {M. W.} and {van Roon-Mom}, {W. M. C.} and Rozing, {M. P.} and {van Hemert}, {A. M.} and Smit, {J. H.} and Beekman, {A. T. F.} and {van Grootheest}, G. and Schoevers, {R. A.} and Voshaar, {R. C. Oude} and Comijs, {H. C.} and Penninx, {B. W. J. H.} and {van der Mast}, {R. C.} and Roos, {R. A. C.} and Aziz, {N. A.}",
year = "2017",
month = "6",
day = "6",
doi = "10.1038/tp.2017.116",
language = "English",
volume = "7",
pages = "1--7",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression

AU - Gardiner, S. L.

AU - van Belzen, M. J.

AU - Boogaard, M. W.

AU - van Roon-Mom, W. M. C.

AU - Rozing, M. P.

AU - van Hemert, A. M.

AU - Smit, J. H.

AU - Beekman, A. T. F.

AU - van Grootheest, G.

AU - Schoevers, R. A.

AU - Voshaar, R. C. Oude

AU - Comijs, H. C.

AU - Penninx, B. W. J. H.

AU - van der Mast, R. C.

AU - Roos, R. A. C.

AU - Aziz, N. A.

PY - 2017/6/6

Y1 - 2017/6/6

N2 - Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine–adenine–guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts—the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons—including 2165 depressed and 1058 non-depressed individuals—aged 18–93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with ≤10, CAG repeats in both ATXN7 alleles (OR=1.90, confidence interval (CI) 1.26–2.85). For TBP we found a similar association: A CAG repeat length exceeding the median in both alleles was associated with an increased risk for lifetime depression (OR=1.33, CI 1.00–1.76). In conclusion, we observed that carriers of either ATXN7 or TBP alleles with relatively large CAG repeat sizes in both alleles had a substantially increased risk of lifetime depression. Our findings provide critical evidence for the notion that repeat polymorphisms can act as complex genetic modifiers of depression.

AB - Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine–adenine–guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts—the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons—including 2165 depressed and 1058 non-depressed individuals—aged 18–93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with ≤10, CAG repeats in both ATXN7 alleles (OR=1.90, confidence interval (CI) 1.26–2.85). For TBP we found a similar association: A CAG repeat length exceeding the median in both alleles was associated with an increased risk for lifetime depression (OR=1.33, CI 1.00–1.76). In conclusion, we observed that carriers of either ATXN7 or TBP alleles with relatively large CAG repeat sizes in both alleles had a substantially increased risk of lifetime depression. Our findings provide critical evidence for the notion that repeat polymorphisms can act as complex genetic modifiers of depression.

U2 - 10.1038/tp.2017.116

DO - 10.1038/tp.2017.116

M3 - Journal article

VL - 7

SP - 1

EP - 7

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

M1 - e1143

ER -

ID: 188197154