An association study between the norepinephrine transporter gene and depression

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

An association study between the norepinephrine transporter gene and depression. / Buttenschøn, Henriette Nørmølle; Jacobsen, Iben Søgaard; Grynderup, Matias B; Hansen, Åse Marie; Kolstad, Henrik A.; Kaerlev, Linda; Thomsen, Jane F; Nordentoft, Merete; Silahtaroglu, Asli; Tommerup, Niels; Tümer, Zeynep; Krogh, Jesper; Børglum, Anders; Mors, Ole.

In: Psychiatric Genetics, Vol. 23, No. 5, 10.2013, p. 217-21.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Buttenschøn, HN, Jacobsen, IS, Grynderup, MB, Hansen, ÅM, Kolstad, HA, Kaerlev, L, Thomsen, JF, Nordentoft, M, Silahtaroglu, A, Tommerup, N, Tümer, Z, Krogh, J, Børglum, A & Mors, O 2013, 'An association study between the norepinephrine transporter gene and depression', Psychiatric Genetics, vol. 23, no. 5, pp. 217-21. https://doi.org/10.1097/YPG.0000000000000003

APA

Buttenschøn, H. N., Jacobsen, I. S., Grynderup, M. B., Hansen, Å. M., Kolstad, H. A., Kaerlev, L., ... Mors, O. (2013). An association study between the norepinephrine transporter gene and depression. Psychiatric Genetics, 23(5), 217-21. https://doi.org/10.1097/YPG.0000000000000003

Vancouver

Buttenschøn HN, Jacobsen IS, Grynderup MB, Hansen ÅM, Kolstad HA, Kaerlev L et al. An association study between the norepinephrine transporter gene and depression. Psychiatric Genetics. 2013 Oct;23(5):217-21. https://doi.org/10.1097/YPG.0000000000000003

Author

Buttenschøn, Henriette Nørmølle ; Jacobsen, Iben Søgaard ; Grynderup, Matias B ; Hansen, Åse Marie ; Kolstad, Henrik A. ; Kaerlev, Linda ; Thomsen, Jane F ; Nordentoft, Merete ; Silahtaroglu, Asli ; Tommerup, Niels ; Tümer, Zeynep ; Krogh, Jesper ; Børglum, Anders ; Mors, Ole. / An association study between the norepinephrine transporter gene and depression. In: Psychiatric Genetics. 2013 ; Vol. 23, No. 5. pp. 217-21.

Bibtex

@article{be6cfbb4d8b74396a812cdd00a3ef67c,
title = "An association study between the norepinephrine transporter gene and depression",
abstract = "A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.",
author = "Buttensch{\o}n, {Henriette N{\o}rm{\o}lle} and Jacobsen, {Iben S{\o}gaard} and Grynderup, {Matias B} and Hansen, {{\AA}se Marie} and Kolstad, {Henrik A.} and Linda Kaerlev and Thomsen, {Jane F} and Merete Nordentoft and Asli Silahtaroglu and Niels Tommerup and Zeynep T{\"u}mer and Jesper Krogh and Anders B{\o}rglum and Ole Mors",
year = "2013",
month = "10",
doi = "10.1097/YPG.0000000000000003",
language = "English",
volume = "23",
pages = "217--21",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - An association study between the norepinephrine transporter gene and depression

AU - Buttenschøn, Henriette Nørmølle

AU - Jacobsen, Iben Søgaard

AU - Grynderup, Matias B

AU - Hansen, Åse Marie

AU - Kolstad, Henrik A.

AU - Kaerlev, Linda

AU - Thomsen, Jane F

AU - Nordentoft, Merete

AU - Silahtaroglu, Asli

AU - Tommerup, Niels

AU - Tümer, Zeynep

AU - Krogh, Jesper

AU - Børglum, Anders

AU - Mors, Ole

PY - 2013/10

Y1 - 2013/10

N2 - A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

AB - A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

U2 - 10.1097/YPG.0000000000000003

DO - 10.1097/YPG.0000000000000003

M3 - Journal article

C2 - 23969988

VL - 23

SP - 217

EP - 221

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 5

ER -

ID: 91429251