Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre. / Bové, Kira Bang; Watt, Torquil; Vogel, Asmus; Hegedüs, Laszlo; Bjørner, Jakob; Grønvold, Mogens; Bonnema, Steen Joop; Rasmussen, Åse Krogh; Feldt-Rasmussen, Ulla.

In: European Thyroid Journal, Vol. 3, No. 3, 09.2014, p. 173-178.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bové, KB, Watt, T, Vogel, A, Hegedüs, L, Bjørner, J, Grønvold, M, Bonnema, SJ, Rasmussen, ÅK & Feldt-Rasmussen, U 2014, 'Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre', European Thyroid Journal, vol. 3, no. 3, pp. 173-178. https://doi.org/10.1159/000365211

APA

Bové, K. B., Watt, T., Vogel, A., Hegedüs, L., Bjørner, J., Grønvold, M., ... Feldt-Rasmussen, U. (2014). Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre. European Thyroid Journal, 3(3), 173-178. https://doi.org/10.1159/000365211

Vancouver

Bové KB, Watt T, Vogel A, Hegedüs L, Bjørner J, Grønvold M et al. Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre. European Thyroid Journal. 2014 Sep;3(3):173-178. https://doi.org/10.1159/000365211

Author

Bové, Kira Bang ; Watt, Torquil ; Vogel, Asmus ; Hegedüs, Laszlo ; Bjørner, Jakob ; Grønvold, Mogens ; Bonnema, Steen Joop ; Rasmussen, Åse Krogh ; Feldt-Rasmussen, Ulla. / Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre. In: European Thyroid Journal. 2014 ; Vol. 3, No. 3. pp. 173-178.

Bibtex

@article{811244a1f386460398514b6ff3e3104e,
title = "Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre",
abstract = "BACKGROUND AND OBJECTIVE: Graves' disease has been associated with an increased psychiatric morbidity. It is unclarified whether this relates to Graves' disease or chronic disease per se. The aim of our study was to estimate the prevalence of anxiety and depression symptoms in patients with Graves' disease compared to patients with another chronic thyroid disease, nodular goitre, and to investigate determinants of anxiety and depression in Graves' disease.METHODS: 157 cross-sectionally sampled patients with Graves' disease, 17 newly diagnosed, 140 treated, and 251 controls with nodular goitre completed the Hospital Anxiety and Depression Scale (HADS). The differences in the mean HADS scores between the groups were analysed using multiple linear regression, controlling for socio-demographic variables. HADS scores were also analysed dichotomized: a score >10 indicating probable 'anxiety'/probable 'depression'. Determinants of anxiety and depression symptoms in Graves' disease were examined using multiple linear regression.RESULTS: In Graves' disease levels of anxiety (p = 0.008) and depression (p = 0.014) were significantly higher than in controls. The prevalence of depression was 10{\%} in Graves' disease versus 4{\%} in nodular goitre (p = 0.038), anxiety was 18 versus 13{\%} (p = 0.131). Symptoms of anxiety (p = 0.04) and depression (p = 0.01) increased with comorbidity. Anxiety symptoms increased with duration of Graves' disease (p = 0.04). Neither thyroid function nor autoantibody levels were associated with anxiety and depression symptoms.CONCLUSIONS: Anxiety and depression symptoms were more severe in Graves' disease than in nodular goitre. Symptoms were positively correlated to comorbidity and duration of Graves' disease but neither to thyroid function nor thyroid autoimmunity.",
author = "Bov{\'e}, {Kira Bang} and Torquil Watt and Asmus Vogel and Laszlo Heged{\"u}s and Jakob Bj{\o}rner and Mogens Gr{\o}nvold and Bonnema, {Steen Joop} and Rasmussen, {{\AA}se Krogh} and Ulla Feldt-Rasmussen",
year = "2014",
month = "9",
doi = "10.1159/000365211",
language = "English",
volume = "3",
pages = "173--178",
journal = "European Thyroid Journal",
issn = "2235-0640",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre

AU - Bové, Kira Bang

AU - Watt, Torquil

AU - Vogel, Asmus

AU - Hegedüs, Laszlo

AU - Bjørner, Jakob

AU - Grønvold, Mogens

AU - Bonnema, Steen Joop

AU - Rasmussen, Åse Krogh

AU - Feldt-Rasmussen, Ulla

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND AND OBJECTIVE: Graves' disease has been associated with an increased psychiatric morbidity. It is unclarified whether this relates to Graves' disease or chronic disease per se. The aim of our study was to estimate the prevalence of anxiety and depression symptoms in patients with Graves' disease compared to patients with another chronic thyroid disease, nodular goitre, and to investigate determinants of anxiety and depression in Graves' disease.METHODS: 157 cross-sectionally sampled patients with Graves' disease, 17 newly diagnosed, 140 treated, and 251 controls with nodular goitre completed the Hospital Anxiety and Depression Scale (HADS). The differences in the mean HADS scores between the groups were analysed using multiple linear regression, controlling for socio-demographic variables. HADS scores were also analysed dichotomized: a score >10 indicating probable 'anxiety'/probable 'depression'. Determinants of anxiety and depression symptoms in Graves' disease were examined using multiple linear regression.RESULTS: In Graves' disease levels of anxiety (p = 0.008) and depression (p = 0.014) were significantly higher than in controls. The prevalence of depression was 10% in Graves' disease versus 4% in nodular goitre (p = 0.038), anxiety was 18 versus 13% (p = 0.131). Symptoms of anxiety (p = 0.04) and depression (p = 0.01) increased with comorbidity. Anxiety symptoms increased with duration of Graves' disease (p = 0.04). Neither thyroid function nor autoantibody levels were associated with anxiety and depression symptoms.CONCLUSIONS: Anxiety and depression symptoms were more severe in Graves' disease than in nodular goitre. Symptoms were positively correlated to comorbidity and duration of Graves' disease but neither to thyroid function nor thyroid autoimmunity.

AB - BACKGROUND AND OBJECTIVE: Graves' disease has been associated with an increased psychiatric morbidity. It is unclarified whether this relates to Graves' disease or chronic disease per se. The aim of our study was to estimate the prevalence of anxiety and depression symptoms in patients with Graves' disease compared to patients with another chronic thyroid disease, nodular goitre, and to investigate determinants of anxiety and depression in Graves' disease.METHODS: 157 cross-sectionally sampled patients with Graves' disease, 17 newly diagnosed, 140 treated, and 251 controls with nodular goitre completed the Hospital Anxiety and Depression Scale (HADS). The differences in the mean HADS scores between the groups were analysed using multiple linear regression, controlling for socio-demographic variables. HADS scores were also analysed dichotomized: a score >10 indicating probable 'anxiety'/probable 'depression'. Determinants of anxiety and depression symptoms in Graves' disease were examined using multiple linear regression.RESULTS: In Graves' disease levels of anxiety (p = 0.008) and depression (p = 0.014) were significantly higher than in controls. The prevalence of depression was 10% in Graves' disease versus 4% in nodular goitre (p = 0.038), anxiety was 18 versus 13% (p = 0.131). Symptoms of anxiety (p = 0.04) and depression (p = 0.01) increased with comorbidity. Anxiety symptoms increased with duration of Graves' disease (p = 0.04). Neither thyroid function nor autoantibody levels were associated with anxiety and depression symptoms.CONCLUSIONS: Anxiety and depression symptoms were more severe in Graves' disease than in nodular goitre. Symptoms were positively correlated to comorbidity and duration of Graves' disease but neither to thyroid function nor thyroid autoimmunity.

U2 - 10.1159/000365211

DO - 10.1159/000365211

M3 - Journal article

C2 - 25538899

VL - 3

SP - 173

EP - 178

JO - European Thyroid Journal

JF - European Thyroid Journal

SN - 2235-0640

IS - 3

ER -

ID: 135551090