Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts

Research output: Contribution to journalJournal articleResearchpeer-review

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Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight : elucidating bias by pooling data from nine European cohorts. / Strandberg-Larsen, Katrine; Poulsen, Gry; Bech, Bodil Hammer; Chatzi, Leda; Cordier, Sylvaine; Dale, Maria Teresa Grønning; Fernandez, Marieta; Henriksen, Tine Brink; Jaddoe, Vincent W. V.; Kogevinas, Manolis; Kruithof, Claudia J.; Lindhard, Morten Søndergaard; Magnus, Per; Nohr, Ellen Aagaard; Richiardi, Lorenzo; Rodriguez-Bernal, Clara L.; Rouget, Florence; Rusconi, Franca; Vrijheid, Martine; Nybo Andersen, Anne-Marie.

In: European Journal of Epidemiology, Vol. 32, No. 9, 09.2017, p. 751-764.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Strandberg-Larsen, K, Poulsen, G, Bech, BH, Chatzi, L, Cordier, S, Dale, MTG, Fernandez, M, Henriksen, TB, Jaddoe, VWV, Kogevinas, M, Kruithof, CJ, Lindhard, MS, Magnus, P, Nohr, EA, Richiardi, L, Rodriguez-Bernal, CL, Rouget, F, Rusconi, F, Vrijheid, M & Nybo Andersen, A-M 2017, 'Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts', European Journal of Epidemiology, vol. 32, no. 9, pp. 751-764. https://doi.org/10.1007/s10654-017-0323-2

APA

Strandberg-Larsen, K., Poulsen, G., Bech, B. H., Chatzi, L., Cordier, S., Dale, M. T. G., ... Nybo Andersen, A-M. (2017). Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. European Journal of Epidemiology, 32(9), 751-764. https://doi.org/10.1007/s10654-017-0323-2

Vancouver

Strandberg-Larsen K, Poulsen G, Bech BH, Chatzi L, Cordier S, Dale MTG et al. Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. European Journal of Epidemiology. 2017 Sep;32(9):751-764. https://doi.org/10.1007/s10654-017-0323-2

Author

Strandberg-Larsen, Katrine ; Poulsen, Gry ; Bech, Bodil Hammer ; Chatzi, Leda ; Cordier, Sylvaine ; Dale, Maria Teresa Grønning ; Fernandez, Marieta ; Henriksen, Tine Brink ; Jaddoe, Vincent W. V. ; Kogevinas, Manolis ; Kruithof, Claudia J. ; Lindhard, Morten Søndergaard ; Magnus, Per ; Nohr, Ellen Aagaard ; Richiardi, Lorenzo ; Rodriguez-Bernal, Clara L. ; Rouget, Florence ; Rusconi, Franca ; Vrijheid, Martine ; Nybo Andersen, Anne-Marie. / Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight : elucidating bias by pooling data from nine European cohorts. In: European Journal of Epidemiology. 2017 ; Vol. 32, No. 9. pp. 751-764.

Bibtex

@article{b2b4d8697e3b4dc38a0ea79c803a5c10,
title = "Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts",
abstract = "Women who drink light-to-moderately during pregnancy have been observed to have lower risk of unfavourable pregnancy outcomes than abstainers. This has been suggested to be a result of bias. In a pooled sample, including 193 747 live-born singletons from nine European cohorts, we examined the associations between light-to-moderate drinking and preterm birth, birth weight, and small-for-gestational age in term born children (term SGA). To address potential sources of bias, we compared the associations from the total sample with a sub-sample restricted to first-time pregnant women who conceived within six months of trying, and examined whether the associations varied across calendar time. In the total sample, drinking up to around six drinks per week as compared to abstaining was associated with lower risk of preterm birth, whereas no significant associations were found for birth weight or term SGA. Drinking six or more drinks per week was associated with lower birth weight and higher risk of term SGA, but no increased risk of preterm birth. The analyses restricted to women without reproductive experience revealed similar results. Before 2000 approximately half of pregnant women drank alcohol. This decreased to 39{\%} in 2000–2004, and 14{\%} in 2005–2011. Before 2000, every additional drink was associated with reduced mean birth weight, whereas in 2005–2011, the mean birth weight increased with increasing intake. The period-specific associations between low-to-moderate drinking and birth weight, which also were observed for term SGA, are indicative of bias. It is impossible to distinguish if the bias is attributable to unmeasured confounding, which change over time or cohort heterogeneity.",
keywords = "Alcohol, Birth weight, Cohort study, Confounding, Preterm birth, Small for gestational age",
author = "Katrine Strandberg-Larsen and Gry Poulsen and Bech, {Bodil Hammer} and Leda Chatzi and Sylvaine Cordier and Dale, {Maria Teresa Gr{\o}nning} and Marieta Fernandez and Henriksen, {Tine Brink} and Jaddoe, {Vincent W. V.} and Manolis Kogevinas and Kruithof, {Claudia J.} and Lindhard, {Morten S{\o}ndergaard} and Per Magnus and Nohr, {Ellen Aagaard} and Lorenzo Richiardi and Rodriguez-Bernal, {Clara L.} and Florence Rouget and Franca Rusconi and Martine Vrijheid and {Nybo Andersen}, Anne-Marie",
year = "2017",
month = "9",
doi = "10.1007/s10654-017-0323-2",
language = "English",
volume = "32",
pages = "751--764",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight

T2 - elucidating bias by pooling data from nine European cohorts

AU - Strandberg-Larsen, Katrine

AU - Poulsen, Gry

AU - Bech, Bodil Hammer

AU - Chatzi, Leda

AU - Cordier, Sylvaine

AU - Dale, Maria Teresa Grønning

AU - Fernandez, Marieta

AU - Henriksen, Tine Brink

AU - Jaddoe, Vincent W. V.

AU - Kogevinas, Manolis

AU - Kruithof, Claudia J.

AU - Lindhard, Morten Søndergaard

AU - Magnus, Per

AU - Nohr, Ellen Aagaard

AU - Richiardi, Lorenzo

AU - Rodriguez-Bernal, Clara L.

AU - Rouget, Florence

AU - Rusconi, Franca

AU - Vrijheid, Martine

AU - Nybo Andersen, Anne-Marie

PY - 2017/9

Y1 - 2017/9

N2 - Women who drink light-to-moderately during pregnancy have been observed to have lower risk of unfavourable pregnancy outcomes than abstainers. This has been suggested to be a result of bias. In a pooled sample, including 193 747 live-born singletons from nine European cohorts, we examined the associations between light-to-moderate drinking and preterm birth, birth weight, and small-for-gestational age in term born children (term SGA). To address potential sources of bias, we compared the associations from the total sample with a sub-sample restricted to first-time pregnant women who conceived within six months of trying, and examined whether the associations varied across calendar time. In the total sample, drinking up to around six drinks per week as compared to abstaining was associated with lower risk of preterm birth, whereas no significant associations were found for birth weight or term SGA. Drinking six or more drinks per week was associated with lower birth weight and higher risk of term SGA, but no increased risk of preterm birth. The analyses restricted to women without reproductive experience revealed similar results. Before 2000 approximately half of pregnant women drank alcohol. This decreased to 39% in 2000–2004, and 14% in 2005–2011. Before 2000, every additional drink was associated with reduced mean birth weight, whereas in 2005–2011, the mean birth weight increased with increasing intake. The period-specific associations between low-to-moderate drinking and birth weight, which also were observed for term SGA, are indicative of bias. It is impossible to distinguish if the bias is attributable to unmeasured confounding, which change over time or cohort heterogeneity.

AB - Women who drink light-to-moderately during pregnancy have been observed to have lower risk of unfavourable pregnancy outcomes than abstainers. This has been suggested to be a result of bias. In a pooled sample, including 193 747 live-born singletons from nine European cohorts, we examined the associations between light-to-moderate drinking and preterm birth, birth weight, and small-for-gestational age in term born children (term SGA). To address potential sources of bias, we compared the associations from the total sample with a sub-sample restricted to first-time pregnant women who conceived within six months of trying, and examined whether the associations varied across calendar time. In the total sample, drinking up to around six drinks per week as compared to abstaining was associated with lower risk of preterm birth, whereas no significant associations were found for birth weight or term SGA. Drinking six or more drinks per week was associated with lower birth weight and higher risk of term SGA, but no increased risk of preterm birth. The analyses restricted to women without reproductive experience revealed similar results. Before 2000 approximately half of pregnant women drank alcohol. This decreased to 39% in 2000–2004, and 14% in 2005–2011. Before 2000, every additional drink was associated with reduced mean birth weight, whereas in 2005–2011, the mean birth weight increased with increasing intake. The period-specific associations between low-to-moderate drinking and birth weight, which also were observed for term SGA, are indicative of bias. It is impossible to distinguish if the bias is attributable to unmeasured confounding, which change over time or cohort heterogeneity.

KW - Alcohol

KW - Birth weight

KW - Cohort study

KW - Confounding

KW - Preterm birth

KW - Small for gestational age

U2 - 10.1007/s10654-017-0323-2

DO - 10.1007/s10654-017-0323-2

M3 - Journal article

VL - 32

SP - 751

EP - 764

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 9

ER -

ID: 188196961