Association of Sleep Disturbances With Reduced Semen Quality: A Cross-sectional Study Among 953 Healthy Young Danish Men

Research output: Contribution to journalJournal articleResearchpeer-review

Tina Kold Jensen, Anna-Maria Andersson, Niels Erik Skakkebæk, Ulla Nordstrøm Joensen, Martin Blomberg Jensen, Tina Harmer Lassen, Loa Nordkap, Inge Alhmann Olesen, Åse Marie Hansen, Naja Hulvej Rod, Niels Jørgensen

Several studies have found an association between sleep duration and morbidity and mortality, but no previous studies have examined the association between sleep disturbances and semen quality. We conducted a cross-sectional study among 953 young Danish men from the general population who were recruited in Copenhagen at the time of determination of fitness for military service between January 2008 and June 2011. All of the men delivered a semen sample, had a blood sample drawn, underwent a physical examination, and answered a questionnaire including information about sleep disturbances. Sleep disturbances were assessed on the basis of a modified 4-item version of the Karolinska Sleep Questionnaire, which includes questions on sleep patterns during the past 4 weeks. Sleep disturbances showed an inverse U-shaped association with sperm concentration, total sperm count, percent motile and percent morphologically normal spermatozoa, and testis size. Men with a high level of sleep disturbance (score >50) had a 29% (95% confidence interval: 2, 48) lower adjusted sperm concentration and 1.6 (95% confidence interval: 0.3, 3.0) percentage points' fewer morphologically normal spermatozoa than men with a sleep score of 11-20. This appears to be the first study to find associations between sleep disturbances and semen quality. In future studies, investigators should attempt to elucidate mechanistic explanations and prospectively assess whether semen quality improves after interventions restoring a normal sleeping pattern.
Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume177
Issue number10
Pages (from-to)1027-1037
ISSN0002-9262
DOIs
Publication statusPublished - 7 Apr 2013

ID: 45154874