Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age

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Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. / Akintola, Abimbola A; van den Berg, Annette; van Buchem, Mark A; Jansen, Steffy W; Slagboom, Eline P; Westendorp, Rudi G; van der Grond, Jeroen; van Heemst, Diana.

In: Frontiers in Aging Neuroscience, Vol. 7, 92, 28.05.2015, p. 1-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Akintola, AA, van den Berg, A, van Buchem, MA, Jansen, SW, Slagboom, EP, Westendorp, RG, van der Grond, J & van Heemst, D 2015, 'Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age', Frontiers in Aging Neuroscience, vol. 7, 92, pp. 1-9. https://doi.org/10.3389/fnagi.2015.00092

APA

Akintola, A. A., van den Berg, A., van Buchem, M. A., Jansen, S. W., Slagboom, E. P., Westendorp, R. G., ... van Heemst, D. (2015). Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. Frontiers in Aging Neuroscience, 7, 1-9. [92]. https://doi.org/10.3389/fnagi.2015.00092

Vancouver

Akintola AA, van den Berg A, van Buchem MA, Jansen SW, Slagboom EP, Westendorp RG et al. Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. Frontiers in Aging Neuroscience. 2015 May 28;7:1-9. 92. https://doi.org/10.3389/fnagi.2015.00092

Author

Akintola, Abimbola A ; van den Berg, Annette ; van Buchem, Mark A ; Jansen, Steffy W ; Slagboom, Eline P ; Westendorp, Rudi G ; van der Grond, Jeroen ; van Heemst, Diana. / Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. In: Frontiers in Aging Neuroscience. 2015 ; Vol. 7. pp. 1-9.

Bibtex

@article{e99029fcaa7840c58705de3430aab904,
title = "Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age",
abstract = "Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here, we investigated the association between parameters of glucose metabolism and microstructural brain integrity in offspring of long-lived families ({"}offspring{"}) and controls; and age categories thereof. From the Leiden Longevity Study (LLS), 132 participants underwent an oral glucose tolerance test (OGTT) to assess glycemia [fasted glucose and glucose area-under-the-curve (AUC)], insulin resistance [fasted insulin, AUCinsulin, and homeostatic model assessment of insulin resistance (HOMA-IR)], and pancreatic Beta cell secretory capacity (insulinogenic index). 3 Tesla MRI and Magnetization Transfer (MT) imaging MT-ratio (MTR) peak-height was used to quantify differences in microstructural brain parenchymal tissue homogeneity that remain invisible on conventional MRI. Analyses were performed in offspring and age-matched controls, with and without stratification for age. In the full offspring group only, reduced MTR peak-height in gray and white matter was inversely associated with AUCinsulin, fasted insulin, HOMA-IR and insulinogenic-index (all p < 0.01). When dichotomized for age (≤65 years and >65 years): in younger controls, significantly stronger inverse associations were observed between MTR peak-height and fasted glucose, AUCglucose, fasted insulin, AUCinsulin and HOMA-IR in gray matter; and for AUCglucose, fasted insulin and HOMA-IR in white matter (all P-interaction < 0.05). Although the strength of the associations tended to attenuate with age in the offspring group, the difference between age groups was not statistically significant. Thus, associations between impaired insulin action and reduced microstructural brain parenchymal tissue homogeneity were stronger in offspring compared to controls, and seemed to diminish with age.",
author = "Akintola, {Abimbola A} and {van den Berg}, Annette and {van Buchem}, {Mark A} and Jansen, {Steffy W} and Slagboom, {Eline P} and Westendorp, {Rudi G} and {van der Grond}, Jeroen and {van Heemst}, Diana",
year = "2015",
month = "5",
day = "28",
doi = "10.3389/fnagi.2015.00092",
language = "English",
volume = "7",
pages = "1--9",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age

AU - Akintola, Abimbola A

AU - van den Berg, Annette

AU - van Buchem, Mark A

AU - Jansen, Steffy W

AU - Slagboom, Eline P

AU - Westendorp, Rudi G

AU - van der Grond, Jeroen

AU - van Heemst, Diana

PY - 2015/5/28

Y1 - 2015/5/28

N2 - Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here, we investigated the association between parameters of glucose metabolism and microstructural brain integrity in offspring of long-lived families ("offspring") and controls; and age categories thereof. From the Leiden Longevity Study (LLS), 132 participants underwent an oral glucose tolerance test (OGTT) to assess glycemia [fasted glucose and glucose area-under-the-curve (AUC)], insulin resistance [fasted insulin, AUCinsulin, and homeostatic model assessment of insulin resistance (HOMA-IR)], and pancreatic Beta cell secretory capacity (insulinogenic index). 3 Tesla MRI and Magnetization Transfer (MT) imaging MT-ratio (MTR) peak-height was used to quantify differences in microstructural brain parenchymal tissue homogeneity that remain invisible on conventional MRI. Analyses were performed in offspring and age-matched controls, with and without stratification for age. In the full offspring group only, reduced MTR peak-height in gray and white matter was inversely associated with AUCinsulin, fasted insulin, HOMA-IR and insulinogenic-index (all p < 0.01). When dichotomized for age (≤65 years and >65 years): in younger controls, significantly stronger inverse associations were observed between MTR peak-height and fasted glucose, AUCglucose, fasted insulin, AUCinsulin and HOMA-IR in gray matter; and for AUCglucose, fasted insulin and HOMA-IR in white matter (all P-interaction < 0.05). Although the strength of the associations tended to attenuate with age in the offspring group, the difference between age groups was not statistically significant. Thus, associations between impaired insulin action and reduced microstructural brain parenchymal tissue homogeneity were stronger in offspring compared to controls, and seemed to diminish with age.

AB - Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here, we investigated the association between parameters of glucose metabolism and microstructural brain integrity in offspring of long-lived families ("offspring") and controls; and age categories thereof. From the Leiden Longevity Study (LLS), 132 participants underwent an oral glucose tolerance test (OGTT) to assess glycemia [fasted glucose and glucose area-under-the-curve (AUC)], insulin resistance [fasted insulin, AUCinsulin, and homeostatic model assessment of insulin resistance (HOMA-IR)], and pancreatic Beta cell secretory capacity (insulinogenic index). 3 Tesla MRI and Magnetization Transfer (MT) imaging MT-ratio (MTR) peak-height was used to quantify differences in microstructural brain parenchymal tissue homogeneity that remain invisible on conventional MRI. Analyses were performed in offspring and age-matched controls, with and without stratification for age. In the full offspring group only, reduced MTR peak-height in gray and white matter was inversely associated with AUCinsulin, fasted insulin, HOMA-IR and insulinogenic-index (all p < 0.01). When dichotomized for age (≤65 years and >65 years): in younger controls, significantly stronger inverse associations were observed between MTR peak-height and fasted glucose, AUCglucose, fasted insulin, AUCinsulin and HOMA-IR in gray matter; and for AUCglucose, fasted insulin and HOMA-IR in white matter (all P-interaction < 0.05). Although the strength of the associations tended to attenuate with age in the offspring group, the difference between age groups was not statistically significant. Thus, associations between impaired insulin action and reduced microstructural brain parenchymal tissue homogeneity were stronger in offspring compared to controls, and seemed to diminish with age.

U2 - 10.3389/fnagi.2015.00092

DO - 10.3389/fnagi.2015.00092

M3 - Journal article

VL - 7

SP - 1

EP - 9

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

M1 - 92

ER -

ID: 140392369