Childhood body mass index and development of type 2 diabetes throughout adult life: A large-scale danish cohort study

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Childhood body mass index and development of type 2 diabetes throughout adult life : A large-scale danish cohort study. / Zimmermann, Esther; Bjerregaard, Lise G.; Gamborg, Michael; Vaag, Allan A.; Sørensen, Thorkild I.A.; Baker, Jennifer L.

In: Obesity, Vol. 25, No. 5, 2017, p. 965-971.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Zimmermann, E, Bjerregaard, LG, Gamborg, M, Vaag, AA, Sørensen, TIA & Baker, JL 2017, 'Childhood body mass index and development of type 2 diabetes throughout adult life: A large-scale danish cohort study', Obesity, vol. 25, no. 5, pp. 965-971. https://doi.org/10.1002/oby.21820

APA

Zimmermann, E., Bjerregaard, L. G., Gamborg, M., Vaag, A. A., Sørensen, T. I. A., & Baker, J. L. (2017). Childhood body mass index and development of type 2 diabetes throughout adult life: A large-scale danish cohort study. Obesity, 25(5), 965-971. https://doi.org/10.1002/oby.21820

Vancouver

Zimmermann E, Bjerregaard LG, Gamborg M, Vaag AA, Sørensen TIA, Baker JL. Childhood body mass index and development of type 2 diabetes throughout adult life: A large-scale danish cohort study. Obesity. 2017;25(5):965-971. https://doi.org/10.1002/oby.21820

Author

Zimmermann, Esther ; Bjerregaard, Lise G. ; Gamborg, Michael ; Vaag, Allan A. ; Sørensen, Thorkild I.A. ; Baker, Jennifer L. / Childhood body mass index and development of type 2 diabetes throughout adult life : A large-scale danish cohort study. In: Obesity. 2017 ; Vol. 25, No. 5. pp. 965-971.

Bibtex

@article{a65e0dfa6e8d4e23b482967f8fe2fc76,
title = "Childhood body mass index and development of type 2 diabetes throughout adult life: A large-scale danish cohort study",
abstract = "OBJECTIVE: This study investigated how a wide spectrum of body mass index (BMI) values at ages 7 to 13 years are associated with type 2 diabetes throughout adulthood, including potential modifying effects of sex and birth weight.METHODS: From the Copenhagen School Health Records Register, 292,827 individuals, born between 1930 and 1989, were followed in national registers for type 2 diabetes (women, n = 7,472; men, n = 11,548). Heights and weights were measured at ages 7 to 13 years.RESULTS: Below-average BMIs, with few exceptions, were not associated with type 2 diabetes. Above-average BMIs had positive associations that were stronger in women than men, stronger in younger birth cohorts, and weaker with older age at diagnosis. Women born 1930-1947, 1948-1965, and 1966-1983 with above-average BMIs at 13 years (≥18.2 kg/m(2) ) had hazard ratios (95{\%} confidence intervals) ranging from 2.12 (1.91-2.36) to 2.84 (2.31-3.49) per z score when diagnosed at 30 to 47 years. Birth weight did not modify these associations.CONCLUSIONS: Childhood BMIs below average are not associated with type 2 diabetes, whereas childhood BMIs above average are strongly associated with type 2 diabetes in adulthood, corresponding to excess risks even at levels below international definitions of overweight. The associations are stronger in women than men but are not affected by birth weight.",
keywords = "Journal Article",
author = "Esther Zimmermann and Bjerregaard, {Lise G.} and Michael Gamborg and Vaag, {Allan A.} and S{\o}rensen, {Thorkild I.A.} and Baker, {Jennifer L.}",
note = "{\circledC} 2017 The Obesity Society.",
year = "2017",
doi = "10.1002/oby.21820",
language = "English",
volume = "25",
pages = "965--971",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Childhood body mass index and development of type 2 diabetes throughout adult life

T2 - A large-scale danish cohort study

AU - Zimmermann, Esther

AU - Bjerregaard, Lise G.

AU - Gamborg, Michael

AU - Vaag, Allan A.

AU - Sørensen, Thorkild I.A.

AU - Baker, Jennifer L.

N1 - © 2017 The Obesity Society.

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: This study investigated how a wide spectrum of body mass index (BMI) values at ages 7 to 13 years are associated with type 2 diabetes throughout adulthood, including potential modifying effects of sex and birth weight.METHODS: From the Copenhagen School Health Records Register, 292,827 individuals, born between 1930 and 1989, were followed in national registers for type 2 diabetes (women, n = 7,472; men, n = 11,548). Heights and weights were measured at ages 7 to 13 years.RESULTS: Below-average BMIs, with few exceptions, were not associated with type 2 diabetes. Above-average BMIs had positive associations that were stronger in women than men, stronger in younger birth cohorts, and weaker with older age at diagnosis. Women born 1930-1947, 1948-1965, and 1966-1983 with above-average BMIs at 13 years (≥18.2 kg/m(2) ) had hazard ratios (95% confidence intervals) ranging from 2.12 (1.91-2.36) to 2.84 (2.31-3.49) per z score when diagnosed at 30 to 47 years. Birth weight did not modify these associations.CONCLUSIONS: Childhood BMIs below average are not associated with type 2 diabetes, whereas childhood BMIs above average are strongly associated with type 2 diabetes in adulthood, corresponding to excess risks even at levels below international definitions of overweight. The associations are stronger in women than men but are not affected by birth weight.

AB - OBJECTIVE: This study investigated how a wide spectrum of body mass index (BMI) values at ages 7 to 13 years are associated with type 2 diabetes throughout adulthood, including potential modifying effects of sex and birth weight.METHODS: From the Copenhagen School Health Records Register, 292,827 individuals, born between 1930 and 1989, were followed in national registers for type 2 diabetes (women, n = 7,472; men, n = 11,548). Heights and weights were measured at ages 7 to 13 years.RESULTS: Below-average BMIs, with few exceptions, were not associated with type 2 diabetes. Above-average BMIs had positive associations that were stronger in women than men, stronger in younger birth cohorts, and weaker with older age at diagnosis. Women born 1930-1947, 1948-1965, and 1966-1983 with above-average BMIs at 13 years (≥18.2 kg/m(2) ) had hazard ratios (95% confidence intervals) ranging from 2.12 (1.91-2.36) to 2.84 (2.31-3.49) per z score when diagnosed at 30 to 47 years. Birth weight did not modify these associations.CONCLUSIONS: Childhood BMIs below average are not associated with type 2 diabetes, whereas childhood BMIs above average are strongly associated with type 2 diabetes in adulthood, corresponding to excess risks even at levels below international definitions of overweight. The associations are stronger in women than men but are not affected by birth weight.

KW - Journal Article

U2 - 10.1002/oby.21820

DO - 10.1002/oby.21820

M3 - Journal article

VL - 25

SP - 965

EP - 971

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -

ID: 183007061