Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample. / Rakhshan, Pamela; Sørensen, Holger Jelling; DeVylder, Jordan; Mittal, Vijay; Mortensen, Erik L; Michelsen, Niels M; Ekstrøm, Morten; Pitts, Steven C; Mednick, Sarnoff A; Schiffman, Jason.

In: Schizophrenia Research, Vol. 178, No. 1-3, 12.2016, p. 68-73.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rakhshan, P, Sørensen, HJ, DeVylder, J, Mittal, V, Mortensen, EL, Michelsen, NM, Ekstrøm, M, Pitts, SC, Mednick, SA & Schiffman, J 2016, 'Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample', Schizophrenia Research, vol. 178, no. 1-3, pp. 68-73. https://doi.org/10.1016/j.schres.2016.08.017

APA

Rakhshan, P., Sørensen, H. J., DeVylder, J., Mittal, V., Mortensen, E. L., Michelsen, N. M., ... Schiffman, J. (2016). Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample. Schizophrenia Research, 178(1-3), 68-73. https://doi.org/10.1016/j.schres.2016.08.017

Vancouver

Rakhshan P, Sørensen HJ, DeVylder J, Mittal V, Mortensen EL, Michelsen NM et al. Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample. Schizophrenia Research. 2016 Dec;178(1-3):68-73. https://doi.org/10.1016/j.schres.2016.08.017

Author

Rakhshan, Pamela ; Sørensen, Holger Jelling ; DeVylder, Jordan ; Mittal, Vijay ; Mortensen, Erik L ; Michelsen, Niels M ; Ekstrøm, Morten ; Pitts, Steven C ; Mednick, Sarnoff A ; Schiffman, Jason. / Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample. In: Schizophrenia Research. 2016 ; Vol. 178, No. 1-3. pp. 68-73.

Bibtex

@article{71edad7663f24554a91b35cd8ab66bbe,
title = "Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample",
abstract = "Motor abnormalities have been established as a core aspect of psychosis-spectrum disorders, with numerous studies identifying deficits prior to clinical symptom presentation. Additional research is needed to pinpoint standardized motor assessments associated with psychosis-spectrum disorders prior to illness onset to enhance prediction and understanding of etiology. With a long history of findings among people with diagnosable psychosis-spectrum disorders, but little research conducted during the premorbid phase, pegboard tasks are a viable and understudied measure of premorbid for psychosis motor functioning. In the current study, examining data from the Copenhagen Perinatal Cohort, the Simultaneous Pegs Test was performed with children (n=244, aged 10-13) at genetic high risk for psychosis (n=94) and controls (n=150). Findings suggest that children who eventually developed a psychosis-spectrum disorder (n=33) were less likely to successfully complete the task within time limit relative to controls (χ(2)(2, N=244)=6.94, p=0.03, ϕ=0.17). Additionally, children who eventually developed a psychosis-spectrum disorder took significantly longer to complete the task relative to controls (χ(2)(2, N=244)=7.06, p=0.03, ϕ=0.17). As pegboard performance is thought to tap both diffuse and specific brain networks, findings suggest that pegboard tests may be useful premorbid measures of motor functioning among those on a trajectory towards a psychosis-spectrum disorder.",
author = "Pamela Rakhshan and S{\o}rensen, {Holger Jelling} and Jordan DeVylder and Vijay Mittal and Mortensen, {Erik L} and Michelsen, {Niels M} and Morten Ekstr{\o}m and Pitts, {Steven C} and Mednick, {Sarnoff A} and Jason Schiffman",
note = "Copyright {\circledC} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
month = "12",
doi = "10.1016/j.schres.2016.08.017",
language = "English",
volume = "178",
pages = "68--73",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample

AU - Rakhshan, Pamela

AU - Sørensen, Holger Jelling

AU - DeVylder, Jordan

AU - Mittal, Vijay

AU - Mortensen, Erik L

AU - Michelsen, Niels M

AU - Ekstrøm, Morten

AU - Pitts, Steven C

AU - Mednick, Sarnoff A

AU - Schiffman, Jason

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016/12

Y1 - 2016/12

N2 - Motor abnormalities have been established as a core aspect of psychosis-spectrum disorders, with numerous studies identifying deficits prior to clinical symptom presentation. Additional research is needed to pinpoint standardized motor assessments associated with psychosis-spectrum disorders prior to illness onset to enhance prediction and understanding of etiology. With a long history of findings among people with diagnosable psychosis-spectrum disorders, but little research conducted during the premorbid phase, pegboard tasks are a viable and understudied measure of premorbid for psychosis motor functioning. In the current study, examining data from the Copenhagen Perinatal Cohort, the Simultaneous Pegs Test was performed with children (n=244, aged 10-13) at genetic high risk for psychosis (n=94) and controls (n=150). Findings suggest that children who eventually developed a psychosis-spectrum disorder (n=33) were less likely to successfully complete the task within time limit relative to controls (χ(2)(2, N=244)=6.94, p=0.03, ϕ=0.17). Additionally, children who eventually developed a psychosis-spectrum disorder took significantly longer to complete the task relative to controls (χ(2)(2, N=244)=7.06, p=0.03, ϕ=0.17). As pegboard performance is thought to tap both diffuse and specific brain networks, findings suggest that pegboard tests may be useful premorbid measures of motor functioning among those on a trajectory towards a psychosis-spectrum disorder.

AB - Motor abnormalities have been established as a core aspect of psychosis-spectrum disorders, with numerous studies identifying deficits prior to clinical symptom presentation. Additional research is needed to pinpoint standardized motor assessments associated with psychosis-spectrum disorders prior to illness onset to enhance prediction and understanding of etiology. With a long history of findings among people with diagnosable psychosis-spectrum disorders, but little research conducted during the premorbid phase, pegboard tasks are a viable and understudied measure of premorbid for psychosis motor functioning. In the current study, examining data from the Copenhagen Perinatal Cohort, the Simultaneous Pegs Test was performed with children (n=244, aged 10-13) at genetic high risk for psychosis (n=94) and controls (n=150). Findings suggest that children who eventually developed a psychosis-spectrum disorder (n=33) were less likely to successfully complete the task within time limit relative to controls (χ(2)(2, N=244)=6.94, p=0.03, ϕ=0.17). Additionally, children who eventually developed a psychosis-spectrum disorder took significantly longer to complete the task relative to controls (χ(2)(2, N=244)=7.06, p=0.03, ϕ=0.17). As pegboard performance is thought to tap both diffuse and specific brain networks, findings suggest that pegboard tests may be useful premorbid measures of motor functioning among those on a trajectory towards a psychosis-spectrum disorder.

U2 - 10.1016/j.schres.2016.08.017

DO - 10.1016/j.schres.2016.08.017

M3 - Journal article

VL - 178

SP - 68

EP - 73

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -

ID: 177525151