Combined effect of lung function level and decline increases morbidity and mortality risks

Research output: Contribution to journalJournal articleResearchpeer-review

Penelope Baughman, Jacob Louis Marott, Peter Lange, Christopher J Martin, Anoop Shankar, Edward L Petsonk, Eva Hnizdo

Abstract Lung function level and decline are each pre-
dictive of morbidity and mortality. Evaluation of the
combined effect of these measurements may help further
identify high-risk groups. Using Copenhagen City Heart
Study longitudinal spirometry data (n = 10,457),
16–21 year risks of chronic obstructive pulmonary disease
(COPD) morbidity, COPD or coronary heart disease mor-
tality, and all-cause mortality were estimated from com-
bined effects of level and decline in forced expiratory
volume in one second (FEV1). Risks were evaluated using
Cox proportional hazards models for individuals grouped
by combinations of baseline predicted FEV1 and quartiles
of slope. Hazard ratios (HR) and 95 % con¿dence intervals

(CI) were estimated using strati¿ed analysis by gender,
smoking status, and baseline age (B45 and [45). For
COPD morbidity, quartiles of increasing FEV1 decline
increased HRs (95 % CI) for individuals with FEV1 at or
above the lower limit of normal (LLN) but below 100 %
predicted, reaching 5.11 (2.58–10.13) for males, 11.63
(4.75–28.46) for females, and 3.09 (0.88–10.86) for never
smokers in the quartile of steepest decline. Signi¿cant
increasing trends were also observed for mortality and in
individuals with a baseline age B45. Groups with ‘normal’
lung function (FEV1 at or above the LLN) but excessive
declines (fourth quartile of FEV1 slope) had signi¿cantly
increased mortality risks, including never smokers and
individuals with a baseline age B45.
Original languageEnglish
JournalEuropean Journal of Epidemiology
Volume27
Pages (from-to)933–943
ISSN0393-2990
DOIs
Publication statusPublished - 2012

ID: 44325205