Determinants of social inequalities in stroke incidence across Europe: a collaborative analysis of 126 635 individuals from 48 cohort studies
Research output: Contribution to journal › Journal article › Research › peer-review
Marco M. Ferrario, Giovanni Veronesi, Frank Kee, Lloyd E. Chambless, Kari Kuulasmaa, Torben Jørgensen, Philippe Amouyel, Dominique Arveiler, Martin Bobak, Giancarlo Cesana, Wojciech Drygas, Jean Ferrieres, Simona Giampaoli, Licia Iacoviello, Yuri Nikitin, Andrzej Pajak, Annette Peters, Veikko Salomaa, Stefan Soderberg, Abdonas Tamosiunas & 2 others
Materials and methods: The MORGAM (MOnica Risk, Genetics, Archiving and Monograph) Study comprises 48 cohorts recruited mostly in the 1980s and 1990s in four European regions using standardised procedures for baseline risk factor assessment and fatal and non-fatal stroke ascertainment and adjudication during follow-up. Among the 126 635 middle-aged participants, initially free of cardiovascular diseases, generating 3788 first stroke events during a median follow-up of 10 years, we estimated differences in stroke rates and HRs for the least versus the most educated individuals.
Results: Compared with their most educated counterparts, the overall age-adjusted excess hazard for stroke was 1.54 (95% CI 1.25 to 1.91) and 1.41 (95% CI 1.16 to 1.71) in least educated men and women, respectively, with little heterogeneity across populations. Educational class inequalities accounted for 86–413 and 78–156 additional stroke events per 100 000 person-years in the least compared with most educated men and women, respectively. The additional events were equivalent to 47%–130% and 40%–89% of the average incidence rates. Inequalities in risk factors accounted for 45%–70% of the social gap in incidence in the Nordic countries, the UK and Lithuania-Kaunas (men), but for no more than 17% in Central and South Europe. The major contributors were cigarette smoking, alcohol intake and body mass index.
Conclusions: Social inequalities in stroke incidence contribute substantially to the disease rates in Europe. Healthier lifestyles in the most disadvantaged individuals should have a prominent impact in reducing both inequalities and the stroke burden.
|Journal||Journal of Epidemiology & Community Health|
|Number of pages||7|
|Publication status||Published - 1 Dec 2017|