Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy. / Winther, Kristian Hillert; Cramon, Per; Watt, Torquil; Bjorner, Jakob Bue; Ekholm, Ola; Feldt-Rasmussen, Ulla; Groenvold, Mogens; Rasmussen, Åse Krogh; Hegedüs, Laszlo; Bonnema, Steen Joop.

In: PLOS ONE, Vol. 11, No. 6, e0156925, 03.06.2016, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Winther, KH, Cramon, P, Watt, T, Bjorner, JB, Ekholm, O, Feldt-Rasmussen, U, Groenvold, M, Rasmussen, ÅK, Hegedüs, L & Bonnema, SJ 2016, 'Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy', PLOS ONE, vol. 11, no. 6, e0156925, pp. 1-12. https://doi.org/10.1371/journal.pone.0156925

APA

Winther, K. H., Cramon, P., Watt, T., Bjorner, J. B., Ekholm, O., Feldt-Rasmussen, U., ... Bonnema, S. J. (2016). Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy. PLOS ONE, 11(6), 1-12. [e0156925]. https://doi.org/10.1371/journal.pone.0156925

Vancouver

Winther KH, Cramon P, Watt T, Bjorner JB, Ekholm O, Feldt-Rasmussen U et al. Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy. PLOS ONE. 2016 Jun 3;11(6):1-12. e0156925. https://doi.org/10.1371/journal.pone.0156925

Author

Winther, Kristian Hillert ; Cramon, Per ; Watt, Torquil ; Bjorner, Jakob Bue ; Ekholm, Ola ; Feldt-Rasmussen, Ulla ; Groenvold, Mogens ; Rasmussen, Åse Krogh ; Hegedüs, Laszlo ; Bonnema, Steen Joop. / Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy. In: PLOS ONE. 2016 ; Vol. 11, No. 6. pp. 1-12.

Bibtex

@article{9e333d4ee2ab42738094878d7ad1bad7,
title = "Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy",
abstract = "BACKGROUND: Hypothyroidism is often diagnosed, and subsequently treated, due to health-related quality of life (HRQL) issues. However, HRQL following treatment has never previously been assessed in longitudinal descriptive studies using validated instruments.OBJECTIVE: To investigate disease-specific (ThyPRO) and generic (SF-36) HRQL, following levothyroxine therapy in patients with hypothyroidism due to autoimmune thyroiditis.METHODS: This prospective cohort study was set at endocrine outpatient clinics at two Danish university hospitals. Seventy-eight consecutive patients were enrolled and completed HRQL questionnaires before, six weeks, and six months after initiation of levothyroxine therapy. Normative ThyPRO (n = 739) and SF-36 (n = 6,638) data were available for comparison and changes in HRQL following treatment were estimated and quantified.RESULTS: Prior to treatment, all ThyPRO scales were significantly impacted (p<0.0001), compared to the general population sample. The same was observed for seven of eight SF-36 scales, the exception being Bodily Pain. Tiredness (ThyPRO) and Vitality (SF-36) were the most markedly impacted scales. After six weeks of treatment, nine of thirteen ThyPRO scales had significantly improved. ThyPRO improvements were consistent at six months, where five of eight SF-36 scales had also significantly improved, but deficits persisted for a subset of both ThyPRO and SF-36 scales.CONCLUSIONS: In this population of hypothyroid patients, HRQL was widely affected before treatment, with tiredness as the cardinal impairment according to both ThyPRO and SF-36. Many aspects of HRQL improved during the first six months of LT4 therapy, but full recovery was not obtained. Our results may help clinicians inform patients about expected clinical treatment effects.",
author = "Winther, {Kristian Hillert} and Per Cramon and Torquil Watt and Bjorner, {Jakob Bue} and Ola Ekholm and Ulla Feldt-Rasmussen and Mogens Groenvold and Rasmussen, {{\AA}se Krogh} and Laszlo Heged{\"u}s and Bonnema, {Steen Joop}",
year = "2016",
month = "6",
day = "3",
doi = "10.1371/journal.pone.0156925",
language = "English",
volume = "11",
pages = "1--12",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

RIS

TY - JOUR

T1 - Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy

AU - Winther, Kristian Hillert

AU - Cramon, Per

AU - Watt, Torquil

AU - Bjorner, Jakob Bue

AU - Ekholm, Ola

AU - Feldt-Rasmussen, Ulla

AU - Groenvold, Mogens

AU - Rasmussen, Åse Krogh

AU - Hegedüs, Laszlo

AU - Bonnema, Steen Joop

PY - 2016/6/3

Y1 - 2016/6/3

N2 - BACKGROUND: Hypothyroidism is often diagnosed, and subsequently treated, due to health-related quality of life (HRQL) issues. However, HRQL following treatment has never previously been assessed in longitudinal descriptive studies using validated instruments.OBJECTIVE: To investigate disease-specific (ThyPRO) and generic (SF-36) HRQL, following levothyroxine therapy in patients with hypothyroidism due to autoimmune thyroiditis.METHODS: This prospective cohort study was set at endocrine outpatient clinics at two Danish university hospitals. Seventy-eight consecutive patients were enrolled and completed HRQL questionnaires before, six weeks, and six months after initiation of levothyroxine therapy. Normative ThyPRO (n = 739) and SF-36 (n = 6,638) data were available for comparison and changes in HRQL following treatment were estimated and quantified.RESULTS: Prior to treatment, all ThyPRO scales were significantly impacted (p<0.0001), compared to the general population sample. The same was observed for seven of eight SF-36 scales, the exception being Bodily Pain. Tiredness (ThyPRO) and Vitality (SF-36) were the most markedly impacted scales. After six weeks of treatment, nine of thirteen ThyPRO scales had significantly improved. ThyPRO improvements were consistent at six months, where five of eight SF-36 scales had also significantly improved, but deficits persisted for a subset of both ThyPRO and SF-36 scales.CONCLUSIONS: In this population of hypothyroid patients, HRQL was widely affected before treatment, with tiredness as the cardinal impairment according to both ThyPRO and SF-36. Many aspects of HRQL improved during the first six months of LT4 therapy, but full recovery was not obtained. Our results may help clinicians inform patients about expected clinical treatment effects.

AB - BACKGROUND: Hypothyroidism is often diagnosed, and subsequently treated, due to health-related quality of life (HRQL) issues. However, HRQL following treatment has never previously been assessed in longitudinal descriptive studies using validated instruments.OBJECTIVE: To investigate disease-specific (ThyPRO) and generic (SF-36) HRQL, following levothyroxine therapy in patients with hypothyroidism due to autoimmune thyroiditis.METHODS: This prospective cohort study was set at endocrine outpatient clinics at two Danish university hospitals. Seventy-eight consecutive patients were enrolled and completed HRQL questionnaires before, six weeks, and six months after initiation of levothyroxine therapy. Normative ThyPRO (n = 739) and SF-36 (n = 6,638) data were available for comparison and changes in HRQL following treatment were estimated and quantified.RESULTS: Prior to treatment, all ThyPRO scales were significantly impacted (p<0.0001), compared to the general population sample. The same was observed for seven of eight SF-36 scales, the exception being Bodily Pain. Tiredness (ThyPRO) and Vitality (SF-36) were the most markedly impacted scales. After six weeks of treatment, nine of thirteen ThyPRO scales had significantly improved. ThyPRO improvements were consistent at six months, where five of eight SF-36 scales had also significantly improved, but deficits persisted for a subset of both ThyPRO and SF-36 scales.CONCLUSIONS: In this population of hypothyroid patients, HRQL was widely affected before treatment, with tiredness as the cardinal impairment according to both ThyPRO and SF-36. Many aspects of HRQL improved during the first six months of LT4 therapy, but full recovery was not obtained. Our results may help clinicians inform patients about expected clinical treatment effects.

U2 - 10.1371/journal.pone.0156925

DO - 10.1371/journal.pone.0156925

M3 - Journal article

VL - 11

SP - 1

EP - 12

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 6

M1 - e0156925

ER -

ID: 162116011