Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors

Research output: Contribution to journalJournal articleResearchpeer-review

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Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors. / Pedersen, Camilla; Bräuner, Elvira V; Rod, Naja Hulvej; Albieri, Vanna; Andersen, Claus E; Ulbak, Kaare; Hertel, Ole; Johansen, Christoffer; Schüz, Joachim; Raaschou-Nielsen, Ole.

In: PLOS ONE, Vol. 9, No. 9, e107096, 09.2014, p. 1-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, C, Bräuner, EV, Rod, NH, Albieri, V, Andersen, CE, Ulbak, K, Hertel, O, Johansen, C, Schüz, J & Raaschou-Nielsen, O 2014, 'Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors', PLOS ONE, vol. 9, no. 9, e107096, pp. 1-7. https://doi.org/10.1371/journal.pone.0107096

APA

Pedersen, C., Bräuner, E. V., Rod, N. H., Albieri, V., Andersen, C. E., Ulbak, K., ... Raaschou-Nielsen, O. (2014). Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors. PLOS ONE, 9(9), 1-7. [e107096]. https://doi.org/10.1371/journal.pone.0107096

Vancouver

Pedersen C, Bräuner EV, Rod NH, Albieri V, Andersen CE, Ulbak K et al. Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors. PLOS ONE. 2014 Sep;9(9):1-7. e107096. https://doi.org/10.1371/journal.pone.0107096

Author

Pedersen, Camilla ; Bräuner, Elvira V ; Rod, Naja Hulvej ; Albieri, Vanna ; Andersen, Claus E ; Ulbak, Kaare ; Hertel, Ole ; Johansen, Christoffer ; Schüz, Joachim ; Raaschou-Nielsen, Ole. / Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors. In: PLOS ONE. 2014 ; Vol. 9, No. 9. pp. 1-7.

Bibtex

@article{227483a9a3a74bfe82caf477f6171a66,
title = "Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors",
abstract = "We investigated whether there is an interaction between distance from residence at birth to nearest power line and domestic radon and traffic-related air pollution, respectively, in relation to childhood leukemia risk. Further, we investigated whether adjusting for potential confounders alters the association between distance to nearest power line and childhood leukemia. We included 1024 cases aged <15, diagnosed with leukemia during 1968-1991, from the Danish Cancer Registry and 2048 controls randomly selected from the Danish childhood population and individually matched by gender and year of birth. We used geographical information systems to determine the distance between residence at birth and the nearest 132-400 kV overhead power line. Concentrations of domestic radon and traffic-related air pollution (NOx at the front door) were estimated using validated models. We found a statistically significant interaction between distance to nearest power line and domestic radon regarding risk of childhood leukemia (p = 0.01) when using the median radon level as cut-off point but not when using the 75th percentile (p = 0.90). We found no evidence of an interaction between distance to nearest power line and traffic-related air pollution (p = 0.73). We found almost no change in the estimated association between distance to power line and risk of childhood leukemia when adjusting for socioeconomic status of the municipality, urbanization, maternal age, birth order, domestic radon and traffic-related air pollution. The statistically significant interaction between distance to nearest power line and domestic radon was based on few exposed cases and controls and sensitive to the choice of exposure categorization and might, therefore, be due to chance.",
author = "Camilla Pedersen and Br{\"a}uner, {Elvira V} and Rod, {Naja Hulvej} and Vanna Albieri and Andersen, {Claus E} and Kaare Ulbak and Ole Hertel and Christoffer Johansen and Joachim Sch{\"u}z and Ole Raaschou-Nielsen",
year = "2014",
month = "9",
doi = "10.1371/journal.pone.0107096",
language = "English",
volume = "9",
pages = "1--7",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Distance to High-Voltage Power Lines and Risk of Childhood Leukemia – an Analysis of Confounding by and Interaction with Other Potential Risk Factors

AU - Pedersen, Camilla

AU - Bräuner, Elvira V

AU - Rod, Naja Hulvej

AU - Albieri, Vanna

AU - Andersen, Claus E

AU - Ulbak, Kaare

AU - Hertel, Ole

AU - Johansen, Christoffer

AU - Schüz, Joachim

AU - Raaschou-Nielsen, Ole

PY - 2014/9

Y1 - 2014/9

N2 - We investigated whether there is an interaction between distance from residence at birth to nearest power line and domestic radon and traffic-related air pollution, respectively, in relation to childhood leukemia risk. Further, we investigated whether adjusting for potential confounders alters the association between distance to nearest power line and childhood leukemia. We included 1024 cases aged <15, diagnosed with leukemia during 1968-1991, from the Danish Cancer Registry and 2048 controls randomly selected from the Danish childhood population and individually matched by gender and year of birth. We used geographical information systems to determine the distance between residence at birth and the nearest 132-400 kV overhead power line. Concentrations of domestic radon and traffic-related air pollution (NOx at the front door) were estimated using validated models. We found a statistically significant interaction between distance to nearest power line and domestic radon regarding risk of childhood leukemia (p = 0.01) when using the median radon level as cut-off point but not when using the 75th percentile (p = 0.90). We found no evidence of an interaction between distance to nearest power line and traffic-related air pollution (p = 0.73). We found almost no change in the estimated association between distance to power line and risk of childhood leukemia when adjusting for socioeconomic status of the municipality, urbanization, maternal age, birth order, domestic radon and traffic-related air pollution. The statistically significant interaction between distance to nearest power line and domestic radon was based on few exposed cases and controls and sensitive to the choice of exposure categorization and might, therefore, be due to chance.

AB - We investigated whether there is an interaction between distance from residence at birth to nearest power line and domestic radon and traffic-related air pollution, respectively, in relation to childhood leukemia risk. Further, we investigated whether adjusting for potential confounders alters the association between distance to nearest power line and childhood leukemia. We included 1024 cases aged <15, diagnosed with leukemia during 1968-1991, from the Danish Cancer Registry and 2048 controls randomly selected from the Danish childhood population and individually matched by gender and year of birth. We used geographical information systems to determine the distance between residence at birth and the nearest 132-400 kV overhead power line. Concentrations of domestic radon and traffic-related air pollution (NOx at the front door) were estimated using validated models. We found a statistically significant interaction between distance to nearest power line and domestic radon regarding risk of childhood leukemia (p = 0.01) when using the median radon level as cut-off point but not when using the 75th percentile (p = 0.90). We found no evidence of an interaction between distance to nearest power line and traffic-related air pollution (p = 0.73). We found almost no change in the estimated association between distance to power line and risk of childhood leukemia when adjusting for socioeconomic status of the municipality, urbanization, maternal age, birth order, domestic radon and traffic-related air pollution. The statistically significant interaction between distance to nearest power line and domestic radon was based on few exposed cases and controls and sensitive to the choice of exposure categorization and might, therefore, be due to chance.

U2 - 10.1371/journal.pone.0107096

DO - 10.1371/journal.pone.0107096

M3 - Journal article

C2 - 25259740

VL - 9

SP - 1

EP - 7

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 9

M1 - e107096

ER -

ID: 124312601