Does educational status impact adult mortality in Denmark? A twin approach

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Does educational status impact adult mortality in Denmark? A twin approach. / Madsen, Mia; Andersen, Anne-Marie Nybo; Christensen, Kaare; Andersen, Per Kragh; Osler, Merete.

In: American Journal of Epidemiology, Vol. 172, No. 2, 07.2010, p. 225-34.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Madsen, M, Andersen, A-MN, Christensen, K, Andersen, PK & Osler, M 2010, 'Does educational status impact adult mortality in Denmark? A twin approach', American Journal of Epidemiology, vol. 172, no. 2, pp. 225-34. https://doi.org/10.1093/aje/kwq072

APA

Madsen, M., Andersen, A-M. N., Christensen, K., Andersen, P. K., & Osler, M. (2010). Does educational status impact adult mortality in Denmark? A twin approach. American Journal of Epidemiology, 172(2), 225-34. https://doi.org/10.1093/aje/kwq072

Vancouver

Madsen M, Andersen A-MN, Christensen K, Andersen PK, Osler M. Does educational status impact adult mortality in Denmark? A twin approach. American Journal of Epidemiology. 2010 Jul;172(2):225-34. https://doi.org/10.1093/aje/kwq072

Author

Madsen, Mia ; Andersen, Anne-Marie Nybo ; Christensen, Kaare ; Andersen, Per Kragh ; Osler, Merete. / Does educational status impact adult mortality in Denmark? A twin approach. In: American Journal of Epidemiology. 2010 ; Vol. 172, No. 2. pp. 225-34.

Bibtex

@article{0c0c5545e7f749689c293fb19d835ebf,
title = "Does educational status impact adult mortality in Denmark? A twin approach",
abstract = "To disentangle an independent effect of educational status on mortality risk from direct and indirect selection mechanisms, the authors used a discordant twin pair design, which allowed them to isolate the effect of education by means of adjustment for genetic and environmental confounding per design. The study is based on data from the Danish Twin Registry and Statistics Denmark. Using Cox regression, they estimated hazard ratios for mortality according to the highest attained education among 5,260 monozygotic and 11,088 dizygotic same-sex twin pairs born during 1921-1950 and followed during 1980-2008. Both standard cohort and intrapair analyses were conducted separately for zygosity, gender, and birth cohort. Educational differences in mortality were demonstrated in the standard cohort analyses but attenuated in the intrapair analyses in all subgroups but men born during 1921-1935, and no effect modification by zygosity was observed. Hence, the results are most compatible with an effect of early family environment in explaining the educational inequality in mortality. However, large educational differences were still reflected in mortality risk differences within twin pairs, thus supporting some degree of independent effect of education. In addition, the effect of education may be more pronounced in older cohorts of Danish men.",
keywords = "Adult, Denmark, Educational Status, Family Relations, Female, Humans, Male, Middle Aged, Mortality, Proportional Hazards Models, Sex Factors, Twins, Dizygotic, Twins, Monozygotic",
author = "Mia Madsen and Andersen, {Anne-Marie Nybo} and Kaare Christensen and Andersen, {Per Kragh} and Merete Osler",
year = "2010",
month = "7",
doi = "10.1093/aje/kwq072",
language = "English",
volume = "172",
pages = "225--34",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Does educational status impact adult mortality in Denmark? A twin approach

AU - Madsen, Mia

AU - Andersen, Anne-Marie Nybo

AU - Christensen, Kaare

AU - Andersen, Per Kragh

AU - Osler, Merete

PY - 2010/7

Y1 - 2010/7

N2 - To disentangle an independent effect of educational status on mortality risk from direct and indirect selection mechanisms, the authors used a discordant twin pair design, which allowed them to isolate the effect of education by means of adjustment for genetic and environmental confounding per design. The study is based on data from the Danish Twin Registry and Statistics Denmark. Using Cox regression, they estimated hazard ratios for mortality according to the highest attained education among 5,260 monozygotic and 11,088 dizygotic same-sex twin pairs born during 1921-1950 and followed during 1980-2008. Both standard cohort and intrapair analyses were conducted separately for zygosity, gender, and birth cohort. Educational differences in mortality were demonstrated in the standard cohort analyses but attenuated in the intrapair analyses in all subgroups but men born during 1921-1935, and no effect modification by zygosity was observed. Hence, the results are most compatible with an effect of early family environment in explaining the educational inequality in mortality. However, large educational differences were still reflected in mortality risk differences within twin pairs, thus supporting some degree of independent effect of education. In addition, the effect of education may be more pronounced in older cohorts of Danish men.

AB - To disentangle an independent effect of educational status on mortality risk from direct and indirect selection mechanisms, the authors used a discordant twin pair design, which allowed them to isolate the effect of education by means of adjustment for genetic and environmental confounding per design. The study is based on data from the Danish Twin Registry and Statistics Denmark. Using Cox regression, they estimated hazard ratios for mortality according to the highest attained education among 5,260 monozygotic and 11,088 dizygotic same-sex twin pairs born during 1921-1950 and followed during 1980-2008. Both standard cohort and intrapair analyses were conducted separately for zygosity, gender, and birth cohort. Educational differences in mortality were demonstrated in the standard cohort analyses but attenuated in the intrapair analyses in all subgroups but men born during 1921-1935, and no effect modification by zygosity was observed. Hence, the results are most compatible with an effect of early family environment in explaining the educational inequality in mortality. However, large educational differences were still reflected in mortality risk differences within twin pairs, thus supporting some degree of independent effect of education. In addition, the effect of education may be more pronounced in older cohorts of Danish men.

KW - Adult

KW - Denmark

KW - Educational Status

KW - Family Relations

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Mortality

KW - Proportional Hazards Models

KW - Sex Factors

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1093/aje/kwq072

DO - 10.1093/aje/kwq072

M3 - Journal article

VL - 172

SP - 225

EP - 234

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 2

ER -

ID: 32326378