Impact of persistence and non-persistence in leisure time physical activity on coronary heart disease and all-cause mortality: The Copenhagen City Heart Study

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Peter Schnohr, James H. O'Keefe, Peter Lange, Gorm Boje Jensen, Jacob Louis Marott

Aims: The aim of this study was to investigate the impact of persistence and non-persistence in leisure time physical activity on coronary heart disease and all-cause mortality.

Methods and results: In the Copenhagen City Heart Study, we prospectively followed 12,314 healthy subjects for 33 years of maximum follow-up with at least two repeated measures of physical activity. The association between persistence and non-persistence in leisure time physical activity, coronary heart disease and all-cause mortality were assessed by multivariable Cox regression analyses. Coronary heart disease mortality for persistent physical activity in leisure compared to persistent sedentary activity were: light hazard ratio (HR) 0.76; 95% confidence interval (CI) 0.63–0.92, moderate HR 0.52; 95% CI 0.41–0.67, and high physical activity HR 0.51; 95% CI, 0.30–0.88. The differences in longevity were 2.8 years for light, 4.5 years for moderate and 5.5 years for high physical activity. A substantial increase in physical activity was associated with lower coronary heart disease mortality (HR 0.75; 95% CI 0.52–1.08) corresponding to 2.4 years longer life, whereas a substantial decrease in physical activity was associated with higher coronary heart disease mortality (HR 1.61; 95% CI 1.11–2.33) corresponding to 4.2 years shorter life than the unchanged group. A similar pattern was observed for all-cause mortality.

Conclusion: We found inverse dose–response relationships between persistent leisure time physical activity and both coronary heart disease and all-cause mortality. A substantial increase in physical activity was associated with a significant gain in longevity, whereas a decrease in physical activity was associated with even greater loss of longevity.
Original languageEnglish
JournalEuropean Journal of Preventive Cardiology
Volume24
Issue number15
Pages (from-to)1615-1623
ISSN2047-4873
DOIs
Publication statusPublished - 1 Oct 2017

    Research areas

  • Physical activity in leisure time, persistence, non-persistence, coronary heart disease, all-cause mortality

ID: 185231972