Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees

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Standard

Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees. / Thielen, Karsten; Nygaard, Else; Rugulies, Reiner; Diderichsen, Finn.

In: Journal of Occupational and Environmental Medicine, Vol. 68, No. 3, 2011, p. 205-10.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thielen, K, Nygaard, E, Rugulies, R & Diderichsen, F 2011, 'Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees', Journal of Occupational and Environmental Medicine, vol. 68, no. 3, pp. 205-10. https://doi.org/10.1136/oem.2010.057943

APA

Thielen, K., Nygaard, E., Rugulies, R., & Diderichsen, F. (2011). Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees. Journal of Occupational and Environmental Medicine, 68(3), 205-10. https://doi.org/10.1136/oem.2010.057943

Vancouver

Thielen K, Nygaard E, Rugulies R, Diderichsen F. Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees. Journal of Occupational and Environmental Medicine. 2011;68(3):205-10. https://doi.org/10.1136/oem.2010.057943

Author

Thielen, Karsten ; Nygaard, Else ; Rugulies, Reiner ; Diderichsen, Finn. / Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees. In: Journal of Occupational and Environmental Medicine. 2011 ; Vol. 68, No. 3. pp. 205-10.

Bibtex

@article{e626e0d053e64534bafa745bfd1f0d0a,
title = "Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees",
abstract = "ABSTRACTObjectives To investigate if exposure to adversepsychological job characteristics predicts incident use ofantidepressants, taking into account differentialmisclassification and residual confounding.Methods A prospective cohort study with a 3.5-yearfollow-up of 4661 Danish employees, aged 40 and50 years, drawn from a 10{\%} random sample of theDanish population was carried out. Job characteristicswere the predictor variables and use of antidepressantswas the outcome variable. Survey data on psychosocialwork environment were linked with register data ondispensing of antidepressant medicine between June2000 and December 2003. Respondents with majordepression at baseline, with antidepressant use in the5 years preceding baseline, or not employed at baselinewere excluded.Results Among men, the OR for antidepressant use wassignificantly increased for high quantitative demands (OR2.12, 95{\%} CI 1.29 to 3.48) and low social support fromcolleagues (OR 2.28, 95{\%} 1.36 to 3.82) after adjustmentfor lifestyle factors, socio-demographic factors,co-morbidity, other work factors and depressivesymptoms at baseline. Both effects were dosedependent. An interaction effect with high demands wasfound for high anticipated private social support andliving with children. Among women, no effect of jobcharacteristics on antidepressant use was found.Conclusion Among men, but not among women, highquantitative demands and low social support fromcolleagues were predictive of incident use ofantidepressants, indicating incident depressive episodes,even after taking into account differentialmisclassification and residual confounding. The effectswere buffered for those with high anticipated privatesocial support and for those having children.",
keywords = "Adult, Antidepressive Agents, Confounding Factors (Epidemiology), Denmark, Depression, Drug Utilization, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Occupational Diseases, Social Support, Stress, Psychological, Depression , Arbejdsmilj{\o}",
author = "Karsten Thielen and Else Nygaard and Reiner Rugulies and Finn Diderichsen",
year = "2011",
doi = "10.1136/oem.2010.057943",
language = "English",
volume = "68",
pages = "205--10",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Job stress and the use of antidepressant medicine: a 3.5-year follow-up study among Danish employees

AU - Thielen, Karsten

AU - Nygaard, Else

AU - Rugulies, Reiner

AU - Diderichsen, Finn

PY - 2011

Y1 - 2011

N2 - ABSTRACTObjectives To investigate if exposure to adversepsychological job characteristics predicts incident use ofantidepressants, taking into account differentialmisclassification and residual confounding.Methods A prospective cohort study with a 3.5-yearfollow-up of 4661 Danish employees, aged 40 and50 years, drawn from a 10% random sample of theDanish population was carried out. Job characteristicswere the predictor variables and use of antidepressantswas the outcome variable. Survey data on psychosocialwork environment were linked with register data ondispensing of antidepressant medicine between June2000 and December 2003. Respondents with majordepression at baseline, with antidepressant use in the5 years preceding baseline, or not employed at baselinewere excluded.Results Among men, the OR for antidepressant use wassignificantly increased for high quantitative demands (OR2.12, 95% CI 1.29 to 3.48) and low social support fromcolleagues (OR 2.28, 95% 1.36 to 3.82) after adjustmentfor lifestyle factors, socio-demographic factors,co-morbidity, other work factors and depressivesymptoms at baseline. Both effects were dosedependent. An interaction effect with high demands wasfound for high anticipated private social support andliving with children. Among women, no effect of jobcharacteristics on antidepressant use was found.Conclusion Among men, but not among women, highquantitative demands and low social support fromcolleagues were predictive of incident use ofantidepressants, indicating incident depressive episodes,even after taking into account differentialmisclassification and residual confounding. The effectswere buffered for those with high anticipated privatesocial support and for those having children.

AB - ABSTRACTObjectives To investigate if exposure to adversepsychological job characteristics predicts incident use ofantidepressants, taking into account differentialmisclassification and residual confounding.Methods A prospective cohort study with a 3.5-yearfollow-up of 4661 Danish employees, aged 40 and50 years, drawn from a 10% random sample of theDanish population was carried out. Job characteristicswere the predictor variables and use of antidepressantswas the outcome variable. Survey data on psychosocialwork environment were linked with register data ondispensing of antidepressant medicine between June2000 and December 2003. Respondents with majordepression at baseline, with antidepressant use in the5 years preceding baseline, or not employed at baselinewere excluded.Results Among men, the OR for antidepressant use wassignificantly increased for high quantitative demands (OR2.12, 95% CI 1.29 to 3.48) and low social support fromcolleagues (OR 2.28, 95% 1.36 to 3.82) after adjustmentfor lifestyle factors, socio-demographic factors,co-morbidity, other work factors and depressivesymptoms at baseline. Both effects were dosedependent. An interaction effect with high demands wasfound for high anticipated private social support andliving with children. Among women, no effect of jobcharacteristics on antidepressant use was found.Conclusion Among men, but not among women, highquantitative demands and low social support fromcolleagues were predictive of incident use ofantidepressants, indicating incident depressive episodes,even after taking into account differentialmisclassification and residual confounding. The effectswere buffered for those with high anticipated privatesocial support and for those having children.

KW - Adult

KW - Antidepressive Agents

KW - Confounding Factors (Epidemiology)

KW - Denmark

KW - Depression

KW - Drug Utilization

KW - Epidemiologic Methods

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Occupational Diseases

KW - Social Support

KW - Stress, Psychological

KW - Depression

KW - Arbejdsmiljø

U2 - 10.1136/oem.2010.057943

DO - 10.1136/oem.2010.057943

M3 - Journal article

VL - 68

SP - 205

EP - 210

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 3

ER -

ID: 33714285