Kombinationsbehandling med fluconazol og andre QTc-forlængende lægemidler forlænger QTc- intervallet

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Several drugs have a QTc-prolonging effect and are metabolized by CYP3A4. The combination of QTc-prolonging drugs may act additive of the QTc interval. The risk increases additionally by co-administration of a CYP3A4-inhibiting substrate. This case report describes an incident with QTc prolongation which was probably caused by an interaction induced by a combination of amiodarone, clarithromycin and the CYP3A4-inhibitor fluconazole.

Original languageDanish
JournalUgeskrift for Laeger
Issue number41
Pages (from-to)V04150371
Publication statusPublished - 5 Oct 2015

    Research areas

  • English Abstract, Journal Article

ID: 178886021