Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health Study

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A F Andersen, C Carson, H C Watt, D A Lawlor, K Avlund, S Ebrahim

Objectives We examined whether area deprivation influenced risk of Type 2 diabetes, fasting blood glucose and insulin resistance over and above the effect of individual socio-economic position (SEP) measured across the life course. Methods A cross-sectional analysis of 4286 women aged 60 to 79 years from 457 British electoral wards in 23 towns. Results Area deprivation was positively associated with diagnosed [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.13, 1.53, per quintile of area deprivation, n = 2895], but not undiagnosed Type 2 diabetes after adjustment for individual life-course SEP. This association was robust to adjustment for adult health behaviours and physiological risk factors. Insulin resistance [homeostasis model assessment (HOMA) score] increased by 1.90% (95% CI 0.01, 3.82, n = 2526) per quintile of area deprivation after adjustment for individual SEP, while fasting blood glucose increased by 0.69% (95% CI 0.16, 1.22, n = 2875) after adjustment for individual SEP. Conclusions Area level deprivation independently influences diagnosed Type 2 diabetes, insulin resistance and fasting blood glucose. Examination of more specific characteristics of places is needed to understand the mechanisms by which these effects arise.
Original languageEnglish
JournalDiabetic Medicine
Volume25
Issue number12
Pages (from-to)1462-8
Number of pages6
ISSN0742-3071
DOIs
Publication statusPublished - 2008

ID: 8878021