Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring

Research output: Contribution to journalJournal articleResearchpeer-review

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Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring. / Søegaard, Signe Holst; Rostgaard, Klaus; Kamper-Jørgensen, Mads; Schmiegelow, Kjeld; Hjalgrim, Henrik.

In: British Journal of Cancer, Vol. 118, No. 1, 2018, p. 117-120.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Søegaard, SH, Rostgaard, K, Kamper-Jørgensen, M, Schmiegelow, K & Hjalgrim, H 2018, 'Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring', British Journal of Cancer, vol. 118, no. 1, pp. 117-120. https://doi.org/10.1038/bjc.2017.351

APA

Søegaard, S. H., Rostgaard, K., Kamper-Jørgensen, M., Schmiegelow, K., & Hjalgrim, H. (2018). Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring. British Journal of Cancer, 118(1), 117-120. https://doi.org/10.1038/bjc.2017.351

Vancouver

Søegaard SH, Rostgaard K, Kamper-Jørgensen M, Schmiegelow K, Hjalgrim H. Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring. British Journal of Cancer. 2018;118(1):117-120. https://doi.org/10.1038/bjc.2017.351

Author

Søegaard, Signe Holst ; Rostgaard, Klaus ; Kamper-Jørgensen, Mads ; Schmiegelow, Kjeld ; Hjalgrim, Henrik. / Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring. In: British Journal of Cancer. 2018 ; Vol. 118, No. 1. pp. 117-120.

Bibtex

@article{58603ed6e7dc4d889f129a92f8356810,
title = "Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring",
abstract = "BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95{\%} confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95{\%} CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.",
author = "S{\o}egaard, {Signe Holst} and Klaus Rostgaard and Mads Kamper-J{\o}rgensen and Kjeld Schmiegelow and Henrik Hjalgrim",
year = "2018",
doi = "10.1038/bjc.2017.351",
language = "English",
volume = "118",
pages = "117--120",
journal = "B J C",
issn = "0007-0920",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring

AU - Søegaard, Signe Holst

AU - Rostgaard, Klaus

AU - Kamper-Jørgensen, Mads

AU - Schmiegelow, Kjeld

AU - Hjalgrim, Henrik

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.

AB - BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.

U2 - 10.1038/bjc.2017.351

DO - 10.1038/bjc.2017.351

M3 - Journal article

VL - 118

SP - 117

EP - 120

JO - B J C

JF - B J C

SN - 0007-0920

IS - 1

ER -

ID: 198662222