Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring

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Signe Holst Søegaard, Klaus Rostgaard, Mads Kamper-Jørgensen, Kjeld Schmiegelow, Henrik Hjalgrim

BACKGROUND: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring.

METHODS: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482).

RESULTS: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes.

CONCLUSIONS: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.

Original languageEnglish
JournalBritish Journal of Cancer
Volume118
Issue number1
Pages (from-to)117-120
Number of pages4
ISSN0007-0920
DOIs
Publication statusPublished - 2018

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