Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study

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Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child : a population-based cohort study. / Petersen, Tanja Gram; Andersen, Anne-Marie Nybo; Uldall, Peter; Paneth, Nigel; Feldt-Rasmussen, Ulla; Tollanes, Mette Christophersen; Strandberg-Larsen, Katrine.

In: BMC Pediatrics, Vol. 18, 181, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Petersen, TG, Andersen, A-MN, Uldall, P, Paneth, N, Feldt-Rasmussen, U, Tollanes, MC & Strandberg-Larsen, K 2018, 'Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study', BMC Pediatrics, vol. 18, 181. https://doi.org/10.1186/s12887-018-1152-5

APA

Petersen, T. G., Andersen, A-M. N., Uldall, P., Paneth, N., Feldt-Rasmussen, U., Tollanes, M. C., & Strandberg-Larsen, K. (2018). Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study. BMC Pediatrics, 18, [181]. https://doi.org/10.1186/s12887-018-1152-5

Vancouver

Petersen TG, Andersen A-MN, Uldall P, Paneth N, Feldt-Rasmussen U, Tollanes MC et al. Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study. BMC Pediatrics. 2018;18. 181. https://doi.org/10.1186/s12887-018-1152-5

Author

Petersen, Tanja Gram ; Andersen, Anne-Marie Nybo ; Uldall, Peter ; Paneth, Nigel ; Feldt-Rasmussen, Ulla ; Tollanes, Mette Christophersen ; Strandberg-Larsen, Katrine. / Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child : a population-based cohort study. In: BMC Pediatrics. 2018 ; Vol. 18.

Bibtex

@article{f3e86462e0694c5ba74dce888d1f9481,
title = "Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study",
abstract = "Background Cerebral palsy is the most frequent motor disability in childhood, but little is known about its etiology. It has been suggested that cerebral palsy risk may be increased by prenatal thyroid hormone disturbances. The objective of this study was to investigate whether maternal thyroid disorder is associated with increased risk of cerebral palsy. Methods A population-based cohort study using two study populations. 1) 1,270,079 children born in Denmark 1979–2007 identified in nationwide registers, and 2) 192,918 children born 1996–2009 recruited into the Danish National Birth Cohort and The Norwegian Mother and Child Cohort study, combined in the MOthers and BAbies in Norway and Denmark (MOBAND) collaboration cohort. Register-based and self-reported information on maternal thyroid disorder was studied in relation to risk of cerebral palsy and its unilateral and bilateral spastic subtypes using multiple logistic regression. Children were followed from the age of 1 year to the age of 6 years, and cerebral palsy was identified in nationwide registers with verified diagnoses. Results In register data, hypothyroidism was recognized in 12,929 (1.0{\%}), hyperthyroidism in 9943 (0.8{\%}), and unclassifiable thyroid disorder in 753 (< 0.1{\%}) of the mothers. The odds ratio for an association between maternal thyroid disorder and bilateral spastic cerebral palsy was 1.0 (95{\%} CI: 0.7–1.5). Maternal thyroid disorder identified during pregnancy was associated with elevated risk of unilateral spastic cerebral palsy (odds ratio 3.1 (95{\%} CI: 1.2–8.4)). In MOBAND, 3042 (1.6{\%}) of the mothers reported a thyroid disorder in pregnancy, which was not associated with cerebral palsy overall (odds ratio 1.2 (95{\%} CI: 0.6–2.4)). Conclusions Maternal thyroid disorder overall was not related to bilateral spastic cerebral palsy, but maternal thyroid disorder identified in pregnancy was associated with increased risk of unilateral spastic cerebral palsy. These findings should be replicated in studies making use of maternal blood samples.",
keywords = "Maternal thyroid disorder, Pregnancy, Prenatal exposure, Cerebral palsy, The Danish National Birth Cohort, The Norwegian mother and child cohort study, Register-based cohort",
author = "Petersen, {Tanja Gram} and Andersen, {Anne-Marie Nybo} and Peter Uldall and Nigel Paneth and Ulla Feldt-Rasmussen and Tollanes, {Mette Christophersen} and Katrine Strandberg-Larsen",
year = "2018",
doi = "10.1186/s12887-018-1152-5",
language = "English",
volume = "18",
journal = "B M C Pediatrics",
issn = "1471-2431",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child

T2 - a population-based cohort study

AU - Petersen, Tanja Gram

AU - Andersen, Anne-Marie Nybo

AU - Uldall, Peter

AU - Paneth, Nigel

AU - Feldt-Rasmussen, Ulla

AU - Tollanes, Mette Christophersen

AU - Strandberg-Larsen, Katrine

PY - 2018

Y1 - 2018

N2 - Background Cerebral palsy is the most frequent motor disability in childhood, but little is known about its etiology. It has been suggested that cerebral palsy risk may be increased by prenatal thyroid hormone disturbances. The objective of this study was to investigate whether maternal thyroid disorder is associated with increased risk of cerebral palsy. Methods A population-based cohort study using two study populations. 1) 1,270,079 children born in Denmark 1979–2007 identified in nationwide registers, and 2) 192,918 children born 1996–2009 recruited into the Danish National Birth Cohort and The Norwegian Mother and Child Cohort study, combined in the MOthers and BAbies in Norway and Denmark (MOBAND) collaboration cohort. Register-based and self-reported information on maternal thyroid disorder was studied in relation to risk of cerebral palsy and its unilateral and bilateral spastic subtypes using multiple logistic regression. Children were followed from the age of 1 year to the age of 6 years, and cerebral palsy was identified in nationwide registers with verified diagnoses. Results In register data, hypothyroidism was recognized in 12,929 (1.0%), hyperthyroidism in 9943 (0.8%), and unclassifiable thyroid disorder in 753 (< 0.1%) of the mothers. The odds ratio for an association between maternal thyroid disorder and bilateral spastic cerebral palsy was 1.0 (95% CI: 0.7–1.5). Maternal thyroid disorder identified during pregnancy was associated with elevated risk of unilateral spastic cerebral palsy (odds ratio 3.1 (95% CI: 1.2–8.4)). In MOBAND, 3042 (1.6%) of the mothers reported a thyroid disorder in pregnancy, which was not associated with cerebral palsy overall (odds ratio 1.2 (95% CI: 0.6–2.4)). Conclusions Maternal thyroid disorder overall was not related to bilateral spastic cerebral palsy, but maternal thyroid disorder identified in pregnancy was associated with increased risk of unilateral spastic cerebral palsy. These findings should be replicated in studies making use of maternal blood samples.

AB - Background Cerebral palsy is the most frequent motor disability in childhood, but little is known about its etiology. It has been suggested that cerebral palsy risk may be increased by prenatal thyroid hormone disturbances. The objective of this study was to investigate whether maternal thyroid disorder is associated with increased risk of cerebral palsy. Methods A population-based cohort study using two study populations. 1) 1,270,079 children born in Denmark 1979–2007 identified in nationwide registers, and 2) 192,918 children born 1996–2009 recruited into the Danish National Birth Cohort and The Norwegian Mother and Child Cohort study, combined in the MOthers and BAbies in Norway and Denmark (MOBAND) collaboration cohort. Register-based and self-reported information on maternal thyroid disorder was studied in relation to risk of cerebral palsy and its unilateral and bilateral spastic subtypes using multiple logistic regression. Children were followed from the age of 1 year to the age of 6 years, and cerebral palsy was identified in nationwide registers with verified diagnoses. Results In register data, hypothyroidism was recognized in 12,929 (1.0%), hyperthyroidism in 9943 (0.8%), and unclassifiable thyroid disorder in 753 (< 0.1%) of the mothers. The odds ratio for an association between maternal thyroid disorder and bilateral spastic cerebral palsy was 1.0 (95% CI: 0.7–1.5). Maternal thyroid disorder identified during pregnancy was associated with elevated risk of unilateral spastic cerebral palsy (odds ratio 3.1 (95% CI: 1.2–8.4)). In MOBAND, 3042 (1.6%) of the mothers reported a thyroid disorder in pregnancy, which was not associated with cerebral palsy overall (odds ratio 1.2 (95% CI: 0.6–2.4)). Conclusions Maternal thyroid disorder overall was not related to bilateral spastic cerebral palsy, but maternal thyroid disorder identified in pregnancy was associated with increased risk of unilateral spastic cerebral palsy. These findings should be replicated in studies making use of maternal blood samples.

KW - Maternal thyroid disorder

KW - Pregnancy

KW - Prenatal exposure

KW - Cerebral palsy

KW - The Danish National Birth Cohort

KW - The Norwegian mother and child cohort study

KW - Register-based cohort

U2 - 10.1186/s12887-018-1152-5

DO - 10.1186/s12887-018-1152-5

M3 - Journal article

VL - 18

JO - B M C Pediatrics

JF - B M C Pediatrics

SN - 1471-2431

M1 - 181

ER -

ID: 209780764