Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions

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Prescribing of Antidiabetic Medicines before, during and after Pregnancy : A Study in Seven European Regions. / Charlton, Rachel A.; Klungsøyr, Kari; Neville, Amanda J.; Jordan, Sue; Pierini, Anna; de Jong-van den Berg, Lolkje T. W.; Bos, H. Jens; Puccini, Aurora; Engeland, Anders; Gini, Rosa; Davies, Gareth; Thayer, Daniel; Hansen, Anne V.; Morgan, Margery; Wang, Hao; McGrogan, Anita; Andersen, Anne-Marie Nybo; Dolk, Helen; Garne, Ester.

In: P L o S One, Vol. 11, No. 5, e0155737, 18.05.2016, p. 1-17.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Charlton, RA, Klungsøyr, K, Neville, AJ, Jordan, S, Pierini, A, de Jong-van den Berg, LTW, Bos, HJ, Puccini, A, Engeland, A, Gini, R, Davies, G, Thayer, D, Hansen, AV, Morgan, M, Wang, H, McGrogan, A, Andersen, A-MN, Dolk, H & Garne, E 2016, 'Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions', P L o S One, vol. 11, no. 5, e0155737, pp. 1-17. https://doi.org/10.1371/journal.pone.0155737

APA

Charlton, R. A., Klungsøyr, K., Neville, A. J., Jordan, S., Pierini, A., de Jong-van den Berg, L. T. W., ... Garne, E. (2016). Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions. P L o S One, 11(5), 1-17. [e0155737]. https://doi.org/10.1371/journal.pone.0155737

Vancouver

Charlton RA, Klungsøyr K, Neville AJ, Jordan S, Pierini A, de Jong-van den Berg LTW et al. Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions. P L o S One. 2016 May 18;11(5):1-17. e0155737. https://doi.org/10.1371/journal.pone.0155737

Author

Charlton, Rachel A. ; Klungsøyr, Kari ; Neville, Amanda J. ; Jordan, Sue ; Pierini, Anna ; de Jong-van den Berg, Lolkje T. W. ; Bos, H. Jens ; Puccini, Aurora ; Engeland, Anders ; Gini, Rosa ; Davies, Gareth ; Thayer, Daniel ; Hansen, Anne V. ; Morgan, Margery ; Wang, Hao ; McGrogan, Anita ; Andersen, Anne-Marie Nybo ; Dolk, Helen ; Garne, Ester. / Prescribing of Antidiabetic Medicines before, during and after Pregnancy : A Study in Seven European Regions. In: P L o S One. 2016 ; Vol. 11, No. 5. pp. 1-17.

Bibtex

@article{b0079ff60360431fa6dc5c212d5b4b97,
title = "Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions",
abstract = "Aim: To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe.Methods: A common protocol was implemented across seven databases in Denmark, Norway, The Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK. Women with a pregnancy starting and ending between 2004 and 2010, (Denmark, 2004–2009; Norway, 2005–2010; Emilia Romagna, 2008–2010), which ended in a live or stillbirth, were identified. Prescriptions for antidiabetic medicines issued (UK) or dispensed (non-UK) during pregnancy and/or the year before or year after pregnancy were identified. Prescribing patterns were compared across databases and over calendar time.Results: 1,082,673 live/stillbirths were identified. Pregestational insulin prescribing during the year before pregnancy ranged from 0.27{\%} (CI95 0.25–0.30) in Tuscany to 0.45{\%} (CI95 0.43–0.47) in Norway, and increased between 2004 and 2009 in all countries. During pregnancy, insulin prescribing peaked during the third trimester and increased over time; third trimester prescribing was highest in Tuscany (2.2{\%}) and lowest in Denmark (0.5{\%}). Of those prescribed an insulin during pregnancy, between 50.5{\%} in Denmark and 88.8{\%} in the Netherlands received an insulin analogue alone or in combination with human insulin, this proportion increasing over time. Oral products were mainly metformin and prescribing was highest in the 3 months before pregnancy. Metformin use during pregnancy increased in some countries.Conclusion: Pregestational diabetes is increasing in many areas of Europe. There is considerable variation between and within countries in the choice of medication for treating pregestational diabetes in pregnancy, including choice of insulin analogues and oral antidiabetics, and very large variation in the treatment of gestational diabetes despite international guidelines.",
author = "Charlton, {Rachel A.} and Kari Klungs{\o}yr and Neville, {Amanda J.} and Sue Jordan and Anna Pierini and {de Jong-van den Berg}, {Lolkje T. W.} and Bos, {H. Jens} and Aurora Puccini and Anders Engeland and Rosa Gini and Gareth Davies and Daniel Thayer and Hansen, {Anne V.} and Margery Morgan and Hao Wang and Anita McGrogan and Andersen, {Anne-Marie Nybo} and Helen Dolk and Ester Garne",
year = "2016",
month = "5",
day = "18",
doi = "10.1371/journal.pone.0155737",
language = "English",
volume = "11",
pages = "1--17",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Prescribing of Antidiabetic Medicines before, during and after Pregnancy

T2 - A Study in Seven European Regions

AU - Charlton, Rachel A.

AU - Klungsøyr, Kari

AU - Neville, Amanda J.

AU - Jordan, Sue

AU - Pierini, Anna

AU - de Jong-van den Berg, Lolkje T. W.

AU - Bos, H. Jens

AU - Puccini, Aurora

AU - Engeland, Anders

AU - Gini, Rosa

AU - Davies, Gareth

AU - Thayer, Daniel

AU - Hansen, Anne V.

AU - Morgan, Margery

AU - Wang, Hao

AU - McGrogan, Anita

AU - Andersen, Anne-Marie Nybo

AU - Dolk, Helen

AU - Garne, Ester

PY - 2016/5/18

Y1 - 2016/5/18

N2 - Aim: To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe.Methods: A common protocol was implemented across seven databases in Denmark, Norway, The Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK. Women with a pregnancy starting and ending between 2004 and 2010, (Denmark, 2004–2009; Norway, 2005–2010; Emilia Romagna, 2008–2010), which ended in a live or stillbirth, were identified. Prescriptions for antidiabetic medicines issued (UK) or dispensed (non-UK) during pregnancy and/or the year before or year after pregnancy were identified. Prescribing patterns were compared across databases and over calendar time.Results: 1,082,673 live/stillbirths were identified. Pregestational insulin prescribing during the year before pregnancy ranged from 0.27% (CI95 0.25–0.30) in Tuscany to 0.45% (CI95 0.43–0.47) in Norway, and increased between 2004 and 2009 in all countries. During pregnancy, insulin prescribing peaked during the third trimester and increased over time; third trimester prescribing was highest in Tuscany (2.2%) and lowest in Denmark (0.5%). Of those prescribed an insulin during pregnancy, between 50.5% in Denmark and 88.8% in the Netherlands received an insulin analogue alone or in combination with human insulin, this proportion increasing over time. Oral products were mainly metformin and prescribing was highest in the 3 months before pregnancy. Metformin use during pregnancy increased in some countries.Conclusion: Pregestational diabetes is increasing in many areas of Europe. There is considerable variation between and within countries in the choice of medication for treating pregestational diabetes in pregnancy, including choice of insulin analogues and oral antidiabetics, and very large variation in the treatment of gestational diabetes despite international guidelines.

AB - Aim: To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe.Methods: A common protocol was implemented across seven databases in Denmark, Norway, The Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK. Women with a pregnancy starting and ending between 2004 and 2010, (Denmark, 2004–2009; Norway, 2005–2010; Emilia Romagna, 2008–2010), which ended in a live or stillbirth, were identified. Prescriptions for antidiabetic medicines issued (UK) or dispensed (non-UK) during pregnancy and/or the year before or year after pregnancy were identified. Prescribing patterns were compared across databases and over calendar time.Results: 1,082,673 live/stillbirths were identified. Pregestational insulin prescribing during the year before pregnancy ranged from 0.27% (CI95 0.25–0.30) in Tuscany to 0.45% (CI95 0.43–0.47) in Norway, and increased between 2004 and 2009 in all countries. During pregnancy, insulin prescribing peaked during the third trimester and increased over time; third trimester prescribing was highest in Tuscany (2.2%) and lowest in Denmark (0.5%). Of those prescribed an insulin during pregnancy, between 50.5% in Denmark and 88.8% in the Netherlands received an insulin analogue alone or in combination with human insulin, this proportion increasing over time. Oral products were mainly metformin and prescribing was highest in the 3 months before pregnancy. Metformin use during pregnancy increased in some countries.Conclusion: Pregestational diabetes is increasing in many areas of Europe. There is considerable variation between and within countries in the choice of medication for treating pregestational diabetes in pregnancy, including choice of insulin analogues and oral antidiabetics, and very large variation in the treatment of gestational diabetes despite international guidelines.

U2 - 10.1371/journal.pone.0155737

DO - 10.1371/journal.pone.0155737

M3 - Journal article

VL - 11

SP - 1

EP - 17

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 5

M1 - e0155737

ER -

ID: 162672256