The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity

Research output: Contribution to journalJournal article

Standard

The CHANGE trial : no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity. / Speyer, Helene; Norgaard, Hans Christian Brix; Birk, Merete; Karlsen, Mette; Storch Jakobsen, Ane; Pedersen, Kamilla; Hjorthoj, Carsten; Pisinger, Charlotta; Gluud, Christian; Mors, Ole; Krogh, Jesper; Nordentoft, Merete.

In: World Psychiatry, Vol. 15, No. 2, 06.2016, p. 155-165.

Research output: Contribution to journalJournal article

Harvard

Speyer, H, Norgaard, HCB, Birk, M, Karlsen, M, Storch Jakobsen, A, Pedersen, K, Hjorthoj, C, Pisinger, C, Gluud, C, Mors, O, Krogh, J & Nordentoft, M 2016, 'The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity', World Psychiatry, vol. 15, no. 2, pp. 155-165. https://doi.org/10.1002/wps.20318

APA

Speyer, H., Norgaard, H. C. B., Birk, M., Karlsen, M., Storch Jakobsen, A., Pedersen, K., ... Nordentoft, M. (2016). The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity. World Psychiatry, 15(2), 155-165. https://doi.org/10.1002/wps.20318

Vancouver

Speyer H, Norgaard HCB, Birk M, Karlsen M, Storch Jakobsen A, Pedersen K et al. The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity. World Psychiatry. 2016 Jun;15(2):155-165. https://doi.org/10.1002/wps.20318

Author

Speyer, Helene ; Norgaard, Hans Christian Brix ; Birk, Merete ; Karlsen, Mette ; Storch Jakobsen, Ane ; Pedersen, Kamilla ; Hjorthoj, Carsten ; Pisinger, Charlotta ; Gluud, Christian ; Mors, Ole ; Krogh, Jesper ; Nordentoft, Merete. / The CHANGE trial : no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity. In: World Psychiatry. 2016 ; Vol. 15, No. 2. pp. 155-165.

Bibtex

@article{01b6ebedd3e348ec93c7537131001e02,
title = "The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity",
abstract = "Life expectancy in patients with schizophrenia is reduced by 20 years for men and 15 years for women compared to the general population. About 60{\%} of the excess mortality is due to physical illnesses, with cardiovascular disease being dominant. CHANGE was a randomized, parallel-group, superiority, multi-centre trial with blinded outcome assessment, testing the efficacy of an intervention aimed to improve cardiovascular risk profile and hereby potentially reduce mortality. A total of 428 patients with schizophrenia spectrum disorders and abdominal obesity were recruited and centrally randomized 1:1:1 to 12 months of lifestyle coaching plus care coordination plus treatment as usual (N=138), or care coordination plus treatment as usual (N=142), or treatment as usual alone (N=148). The primary outcome was 10-year risk of cardiovascular disease assessed post-treatment and standardized to age 60. At follow-up, the mean 10-year risk of cardiovascular disease was 8.4 ± 6.7{\%} in the group receiving lifestyle coaching, 8.5 ± 7.5{\%} in the care coordination group, and 8.0 ± 6.5{\%} in the treatment as usual group (p=0.41). We found no intervention effects for any secondary or exploratory outcomes, including cardiorespiratory fitness, physical activity, weight, diet and smoking. In conclusion, the CHANGE trial did not support superiority of individual lifestyle coaching or care coordination compared to treatment as usual in reducing cardiovascular risk in patients with schizophrenia spectrum disorders and abdominal obesity.",
keywords = "Schizophrenia, abdominal obesity, CHANGE trial, lifestyle coaching, care coordination, cardiovascular risk, cardiorespiratory fitness, physical activity",
author = "Helene Speyer and Norgaard, {Hans Christian Brix} and Merete Birk and Mette Karlsen and {Storch Jakobsen}, Ane and Kamilla Pedersen and Carsten Hjorthoj and Charlotta Pisinger and Christian Gluud and Ole Mors and Jesper Krogh and Merete Nordentoft",
year = "2016",
month = "6",
doi = "10.1002/wps.20318",
language = "English",
volume = "15",
pages = "155--165",
journal = "World Psychiatry",
issn = "1723-8617",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - The CHANGE trial

T2 - no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity

AU - Speyer, Helene

AU - Norgaard, Hans Christian Brix

AU - Birk, Merete

AU - Karlsen, Mette

AU - Storch Jakobsen, Ane

AU - Pedersen, Kamilla

AU - Hjorthoj, Carsten

AU - Pisinger, Charlotta

AU - Gluud, Christian

AU - Mors, Ole

AU - Krogh, Jesper

AU - Nordentoft, Merete

PY - 2016/6

Y1 - 2016/6

N2 - Life expectancy in patients with schizophrenia is reduced by 20 years for men and 15 years for women compared to the general population. About 60% of the excess mortality is due to physical illnesses, with cardiovascular disease being dominant. CHANGE was a randomized, parallel-group, superiority, multi-centre trial with blinded outcome assessment, testing the efficacy of an intervention aimed to improve cardiovascular risk profile and hereby potentially reduce mortality. A total of 428 patients with schizophrenia spectrum disorders and abdominal obesity were recruited and centrally randomized 1:1:1 to 12 months of lifestyle coaching plus care coordination plus treatment as usual (N=138), or care coordination plus treatment as usual (N=142), or treatment as usual alone (N=148). The primary outcome was 10-year risk of cardiovascular disease assessed post-treatment and standardized to age 60. At follow-up, the mean 10-year risk of cardiovascular disease was 8.4 ± 6.7% in the group receiving lifestyle coaching, 8.5 ± 7.5% in the care coordination group, and 8.0 ± 6.5% in the treatment as usual group (p=0.41). We found no intervention effects for any secondary or exploratory outcomes, including cardiorespiratory fitness, physical activity, weight, diet and smoking. In conclusion, the CHANGE trial did not support superiority of individual lifestyle coaching or care coordination compared to treatment as usual in reducing cardiovascular risk in patients with schizophrenia spectrum disorders and abdominal obesity.

AB - Life expectancy in patients with schizophrenia is reduced by 20 years for men and 15 years for women compared to the general population. About 60% of the excess mortality is due to physical illnesses, with cardiovascular disease being dominant. CHANGE was a randomized, parallel-group, superiority, multi-centre trial with blinded outcome assessment, testing the efficacy of an intervention aimed to improve cardiovascular risk profile and hereby potentially reduce mortality. A total of 428 patients with schizophrenia spectrum disorders and abdominal obesity were recruited and centrally randomized 1:1:1 to 12 months of lifestyle coaching plus care coordination plus treatment as usual (N=138), or care coordination plus treatment as usual (N=142), or treatment as usual alone (N=148). The primary outcome was 10-year risk of cardiovascular disease assessed post-treatment and standardized to age 60. At follow-up, the mean 10-year risk of cardiovascular disease was 8.4 ± 6.7% in the group receiving lifestyle coaching, 8.5 ± 7.5% in the care coordination group, and 8.0 ± 6.5% in the treatment as usual group (p=0.41). We found no intervention effects for any secondary or exploratory outcomes, including cardiorespiratory fitness, physical activity, weight, diet and smoking. In conclusion, the CHANGE trial did not support superiority of individual lifestyle coaching or care coordination compared to treatment as usual in reducing cardiovascular risk in patients with schizophrenia spectrum disorders and abdominal obesity.

KW - Schizophrenia

KW - abdominal obesity

KW - CHANGE trial

KW - lifestyle coaching

KW - care coordination

KW - cardiovascular risk

KW - cardiorespiratory fitness

KW - physical activity

U2 - 10.1002/wps.20318

DO - 10.1002/wps.20318

M3 - Journal article

C2 - 27265706

VL - 15

SP - 155

EP - 165

JO - World Psychiatry

JF - World Psychiatry

SN - 1723-8617

IS - 2

ER -

ID: 173981413