Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry

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Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry. / Christensen, M E; Therkildsen, M H; Poulsen, Steen Seier; Bretlau, P.

In: Acta Oto-Laryngologica, Vol. 113, No. 4, 07.1993, p. 563-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, ME, Therkildsen, MH, Poulsen, SS & Bretlau, P 1993, 'Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry', Acta Oto-Laryngologica, vol. 113, no. 4, pp. 563-7.

APA

Christensen, M. E., Therkildsen, M. H., Poulsen, S. S., & Bretlau, P. (1993). Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry. Acta Oto-Laryngologica, 113(4), 563-7.

Vancouver

Christensen ME, Therkildsen MH, Poulsen SS, Bretlau P. Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry. Acta Oto-Laryngologica. 1993 Jul;113(4):563-7.

Author

Christensen, M E ; Therkildsen, M H ; Poulsen, Steen Seier ; Bretlau, P. / Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry. In: Acta Oto-Laryngologica. 1993 ; Vol. 113, No. 4. pp. 563-7.

Bibtex

@article{915d544bc9f5499e828139bc4e8ec7ca,
title = "Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry",
abstract = "Fifteen laryngeal squamous cell carcinomas were investigated for the presence of transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) using immunohistochemical methods. In a recent study the same material was characterized for epidermal growth factor receptors (EGF receptors) which were confined predominantly to the undifferentiated cells. The expression of this growth factor system in malignant cells may play a role in carcinogenesis and/or tumour growth. All carcinomas were positive for TGF-alpha and 12 were positive for EGF. In moderately-to-well differentiated carcinomas, the immunoreactivity was mainly detected in the cytologically more differentiated cells. Nine sections included both laryngeal stratified squamous epithelium of normal appearance and carcinoma. The immunoreactivity was here again localized in the cytologically more differentiated cells above the basal cell layer. The present investigation and our previous results confirm the existence of EGF receptors, TGF-alpha and EGF in laryngeal carcinomas. In addition, we conclude that the conditions do exist for growth factors to act through an autocrine system in poorly differentiated tumours and through a paracrine system in the moderately-to-well differentiated tumours.",
keywords = "Carcinoma, Squamous Cell, Cell Differentiation, Cytoplasm, Endothelium, Epidermal Growth Factor, Epithelium, Exocrine Glands, Female, Humans, Immunohistochemistry, Keratins, Laryngeal Muscles, Laryngeal Neoplasms, Macrophages, Male, Mucins, Neoplasm Staging, Transforming Growth Factor alpha",
author = "Christensen, {M E} and Therkildsen, {M H} and Poulsen, {Steen Seier} and P Bretlau",
year = "1993",
month = "7",
language = "English",
volume = "113",
pages = "563--7",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry

AU - Christensen, M E

AU - Therkildsen, M H

AU - Poulsen, Steen Seier

AU - Bretlau, P

PY - 1993/7

Y1 - 1993/7

N2 - Fifteen laryngeal squamous cell carcinomas were investigated for the presence of transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) using immunohistochemical methods. In a recent study the same material was characterized for epidermal growth factor receptors (EGF receptors) which were confined predominantly to the undifferentiated cells. The expression of this growth factor system in malignant cells may play a role in carcinogenesis and/or tumour growth. All carcinomas were positive for TGF-alpha and 12 were positive for EGF. In moderately-to-well differentiated carcinomas, the immunoreactivity was mainly detected in the cytologically more differentiated cells. Nine sections included both laryngeal stratified squamous epithelium of normal appearance and carcinoma. The immunoreactivity was here again localized in the cytologically more differentiated cells above the basal cell layer. The present investigation and our previous results confirm the existence of EGF receptors, TGF-alpha and EGF in laryngeal carcinomas. In addition, we conclude that the conditions do exist for growth factors to act through an autocrine system in poorly differentiated tumours and through a paracrine system in the moderately-to-well differentiated tumours.

AB - Fifteen laryngeal squamous cell carcinomas were investigated for the presence of transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) using immunohistochemical methods. In a recent study the same material was characterized for epidermal growth factor receptors (EGF receptors) which were confined predominantly to the undifferentiated cells. The expression of this growth factor system in malignant cells may play a role in carcinogenesis and/or tumour growth. All carcinomas were positive for TGF-alpha and 12 were positive for EGF. In moderately-to-well differentiated carcinomas, the immunoreactivity was mainly detected in the cytologically more differentiated cells. Nine sections included both laryngeal stratified squamous epithelium of normal appearance and carcinoma. The immunoreactivity was here again localized in the cytologically more differentiated cells above the basal cell layer. The present investigation and our previous results confirm the existence of EGF receptors, TGF-alpha and EGF in laryngeal carcinomas. In addition, we conclude that the conditions do exist for growth factors to act through an autocrine system in poorly differentiated tumours and through a paracrine system in the moderately-to-well differentiated tumours.

KW - Carcinoma, Squamous Cell

KW - Cell Differentiation

KW - Cytoplasm

KW - Endothelium

KW - Epidermal Growth Factor

KW - Epithelium

KW - Exocrine Glands

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Keratins

KW - Laryngeal Muscles

KW - Laryngeal Neoplasms

KW - Macrophages

KW - Male

KW - Mucins

KW - Neoplasm Staging

KW - Transforming Growth Factor alpha

M3 - Journal article

C2 - 7691024

VL - 113

SP - 563

EP - 567

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 4

ER -

ID: 47487490