Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry

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M E Christensen, M H Therkildsen, Steen Seier Poulsen, P Bretlau

Fifteen laryngeal squamous cell carcinomas were investigated for the presence of transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) using immunohistochemical methods. In a recent study the same material was characterized for epidermal growth factor receptors (EGF receptors) which were confined predominantly to the undifferentiated cells. The expression of this growth factor system in malignant cells may play a role in carcinogenesis and/or tumour growth. All carcinomas were positive for TGF-alpha and 12 were positive for EGF. In moderately-to-well differentiated carcinomas, the immunoreactivity was mainly detected in the cytologically more differentiated cells. Nine sections included both laryngeal stratified squamous epithelium of normal appearance and carcinoma. The immunoreactivity was here again localized in the cytologically more differentiated cells above the basal cell layer. The present investigation and our previous results confirm the existence of EGF receptors, TGF-alpha and EGF in laryngeal carcinomas. In addition, we conclude that the conditions do exist for growth factors to act through an autocrine system in poorly differentiated tumours and through a paracrine system in the moderately-to-well differentiated tumours.
Original languageEnglish
JournalActa Oto-Laryngologica
Volume113
Issue number4
Pages (from-to)563-7
Number of pages5
ISSN0001-6489
Publication statusPublished - Jul 1993

    Research areas

  • Carcinoma, Squamous Cell, Cell Differentiation, Cytoplasm, Endothelium, Epidermal Growth Factor, Epithelium, Exocrine Glands, Female, Humans, Immunohistochemistry, Keratins, Laryngeal Muscles, Laryngeal Neoplasms, Macrophages, Male, Mucins, Neoplasm Staging, Transforming Growth Factor alpha

ID: 47487490