Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. / Petersen, Tanja Gram; Liew, Zeyan; Nybo Andersen, Anne-Marie; Andersen, Guro L.; Andersen, Per Kragh; Martinussen, Torben; Olsen, Jørn; Rebordosa, Cristina; Tollånes, Mette Christophersen; Uldall, Peter; Wilcox, Allen J.; Strandberg-Larsen, Katrine.

In: International Journal of Epidemiology, Vol. 47, No. 1, 2018, p. 121–130.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Petersen, TG, Liew, Z, Nybo Andersen, A-M, Andersen, GL, Andersen, PK, Martinussen, T, Olsen, J, Rebordosa, C, Tollånes, MC, Uldall, P, Wilcox, AJ & Strandberg-Larsen, K 2018, 'Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child', International Journal of Epidemiology, vol. 47, no. 1, pp. 121–130. https://doi.org/10.1093/ije/dyx235

APA

Petersen, T. G., Liew, Z., Nybo Andersen, A-M., Andersen, G. L., Andersen, P. K., Martinussen, T., ... Strandberg-Larsen, K. (2018). Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. International Journal of Epidemiology, 47(1), 121–130. https://doi.org/10.1093/ije/dyx235

Vancouver

Petersen TG, Liew Z, Nybo Andersen A-M, Andersen GL, Andersen PK, Martinussen T et al. Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. International Journal of Epidemiology. 2018;47(1):121–130. https://doi.org/10.1093/ije/dyx235

Author

Petersen, Tanja Gram ; Liew, Zeyan ; Nybo Andersen, Anne-Marie ; Andersen, Guro L. ; Andersen, Per Kragh ; Martinussen, Torben ; Olsen, Jørn ; Rebordosa, Cristina ; Tollånes, Mette Christophersen ; Uldall, Peter ; Wilcox, Allen J. ; Strandberg-Larsen, Katrine. / Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. In: International Journal of Epidemiology. 2018 ; Vol. 47, No. 1. pp. 121–130.

Bibtex

@article{e1a5b8287ce64a9597a016686fa520b4,
title = "Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child",
abstract = "Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child.Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders. Children with CP were identified in nationwide registers. We estimated the average causal effect of analgesics on risk of CP using marginal structural models with stabilized inverse probability weights.Results: Paracetamol use was reported in 49{\%} of all pregnancies, aspirin in 3{\%} and ibuprofen in 4{\%}. Prenatal exposure to paracetamol ever in pregnancy was associated with increased risk of overall CP [adjusted odds ratio (aOR) 1.3, 95{\%} confidence interval (CI): 1.0-1.7] and unilateral spastic CP (aOR 1.5, 95{\%} CI: 1.0-2.2). The association appeared to be driven by an increased risk of unilateral spastic CP in children exposed in second trimester (aOR 1.6, 95{\%} CI: 1.0-2.5). Children ever prenatally exposed to aspirin in pregnancy had an elevated risk of bilateral spastic CP (aOR 2.4, 95{\%} CI: 1.1-5.3) compared with unexposed.Conclusion: We observed an increased risk of spastic CP in children prenatally exposed to paracetamol and aspirin. Although we controlled for several important indications for analgesic use, we cannot exclude the possibility of confounding by underlying diseases.",
keywords = "Journal Article",
author = "Petersen, {Tanja Gram} and Zeyan Liew and {Nybo Andersen}, Anne-Marie and Andersen, {Guro L.} and Andersen, {Per Kragh} and Torben Martinussen and J{\o}rn Olsen and Cristina Rebordosa and Toll{\aa}nes, {Mette Christophersen} and Peter Uldall and Wilcox, {Allen J.} and Katrine Strandberg-Larsen",
year = "2018",
doi = "10.1093/ije/dyx235",
language = "English",
volume = "47",
pages = "121–130",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child

AU - Petersen, Tanja Gram

AU - Liew, Zeyan

AU - Nybo Andersen, Anne-Marie

AU - Andersen, Guro L.

AU - Andersen, Per Kragh

AU - Martinussen, Torben

AU - Olsen, Jørn

AU - Rebordosa, Cristina

AU - Tollånes, Mette Christophersen

AU - Uldall, Peter

AU - Wilcox, Allen J.

AU - Strandberg-Larsen, Katrine

PY - 2018

Y1 - 2018

N2 - Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child.Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders. Children with CP were identified in nationwide registers. We estimated the average causal effect of analgesics on risk of CP using marginal structural models with stabilized inverse probability weights.Results: Paracetamol use was reported in 49% of all pregnancies, aspirin in 3% and ibuprofen in 4%. Prenatal exposure to paracetamol ever in pregnancy was associated with increased risk of overall CP [adjusted odds ratio (aOR) 1.3, 95% confidence interval (CI): 1.0-1.7] and unilateral spastic CP (aOR 1.5, 95% CI: 1.0-2.2). The association appeared to be driven by an increased risk of unilateral spastic CP in children exposed in second trimester (aOR 1.6, 95% CI: 1.0-2.5). Children ever prenatally exposed to aspirin in pregnancy had an elevated risk of bilateral spastic CP (aOR 2.4, 95% CI: 1.1-5.3) compared with unexposed.Conclusion: We observed an increased risk of spastic CP in children prenatally exposed to paracetamol and aspirin. Although we controlled for several important indications for analgesic use, we cannot exclude the possibility of confounding by underlying diseases.

AB - Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child.Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders. Children with CP were identified in nationwide registers. We estimated the average causal effect of analgesics on risk of CP using marginal structural models with stabilized inverse probability weights.Results: Paracetamol use was reported in 49% of all pregnancies, aspirin in 3% and ibuprofen in 4%. Prenatal exposure to paracetamol ever in pregnancy was associated with increased risk of overall CP [adjusted odds ratio (aOR) 1.3, 95% confidence interval (CI): 1.0-1.7] and unilateral spastic CP (aOR 1.5, 95% CI: 1.0-2.2). The association appeared to be driven by an increased risk of unilateral spastic CP in children exposed in second trimester (aOR 1.6, 95% CI: 1.0-2.5). Children ever prenatally exposed to aspirin in pregnancy had an elevated risk of bilateral spastic CP (aOR 2.4, 95% CI: 1.1-5.3) compared with unexposed.Conclusion: We observed an increased risk of spastic CP in children prenatally exposed to paracetamol and aspirin. Although we controlled for several important indications for analgesic use, we cannot exclude the possibility of confounding by underlying diseases.

KW - Journal Article

U2 - 10.1093/ije/dyx235

DO - 10.1093/ije/dyx235

M3 - Journal article

VL - 47

SP - 121

EP - 130

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 1

ER -

ID: 185944079