Life course and aging

It is increasingly recognized that the aging process is shaped over the life course. Disadvantage in childhood, adolescence and early adulthood increases the risk of early onset of chronic disease and loss of functional ability. Aging can manifest as subclinical adverse levels of biological and physiological indicators, as well as onset of physical or cognitive decline or fatigue in daily activities.

Research program

We aim to investigate the influence of factors in childhood, adolescence, adulthood and cross generational (e.g. adverse socioeconomic position, social relations, psychosocial stressors and health problems) on aging (e.g. levels of inflammatory markers, allostatic load, physical and cognitive function). Furthermore, we aim to investigate the association between midlife markers of aging on later life development of disability, disease and mortality. We additionally aim to map potential mediating pathways linking early life exposures with aging outcomes.


Selected references:

Lund R, Mortensen EL, Christensen U, Bruunsgaard H, Holm-Pedersen P, Fiehn NE, Molbo D, Jepsen E, Hansen ÅM, Osler M. Cohort Profile: The Copenhagen Aging and Midlife Biobank (CAMB). International Journal of Epidemiology, 2016 1044-1053

Foverskov E, Mortensen EL, Holm A, Pedersen JLM, Osler M, Lund R. Socioeconomic Position Across the Life Course and Cognitive Ability Later in Life: The Importance of Considering Early Cognitive Ability. J Aging Health. 2017

Lund R, Laban J, Petersen GL, Dissing A, Hansen ÅM, Rod NH. Loneliness and objectively measured physical capability in middle-aged adults. European Journal of Public Health, 1–8 2017

Pedersen et al. Prenatal and early postnatal stress and later life inflammation. Psychoneuroendocrinology, 2018