A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise

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G Paulsen, I M Egner, M Drange, Henning Langberg, H B Benestad, J G Fjeld, J Hallén, T Raastad

The aim of this study was to investigate the effect of a cyclooxygenase (COX)-2 inhibitor on the recovery of muscle function, inflammation, regeneration after, and adaptation to, unaccustomed eccentric exercise. Thirty-three young males and females participated in a double-blind, placebo-controlled experiment. Seventy unilateral, voluntary, maximal eccentric actions with the elbow flexors were performed twice (bouts 1 and 2) with the same arm, separated by 3 weeks. The test group participants were administered 400 mg/day of celecoxib for 9 days after bout 1. After both bouts 1 and 2, concentric and isometric force-generating capacity was immediately reduced (approximately 40-50%), followed by the later appearance of muscle soreness and increased serum creatine kinase levels. Radiolabelled autologous leukocytes (detected by scintigraphy) and monocytes/macrophages (histology) accumulated in the exercised muscles, simultaneously with increased satellite cell activity. These responses were reduced and recovery was faster after bout 2 than 1, demonstrating a repeated-bout effect. No differences between the celecoxib and placebo groups were detected, except for muscle soreness, which was attenuated by celecoxib. In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect. However, it alleviated muscle soreness.
Original languageEnglish
JournalScandinavian Journal of Medicine & Science in Sports
Volume20
Issue number1
Pages (from-to)e195-207
ISSN0905-7188
DOIs
Publication statusPublished - 2010

    Research areas

  • Adaptation, Physiological, Adult, Arm, Cyclooxygenase 2 Inhibitors, Dinoprostone, Double-Blind Method, Exercise, Female, Humans, Immunohistochemistry, Isometric Contraction, Leukocytes, Male, Microdialysis, Muscle Contraction, Muscle, Skeletal, Pain, Pyrazoles, Recovery of Function, Satellite Cells, Skeletal Muscle, Sulfonamides, Young Adult

ID: 38364620