Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

Research output: Contribution to journalJournal articleResearchpeer-review

M Hansen, Henning Langberg, L Holm, B F Miller, S G Petersen, S Doessing, D Skovgaard, T Trappe, M Kjaer

Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P
Original languageEnglish
JournalScandinavian Journal of Medicine & Science in Sports
Volume21
Issue number1
Pages (from-to)62-72
Number of pages11
ISSN0905-7188
DOIs
Publication statusPublished - 2011

    Research areas

  • Analysis of Variance, Contraceptives, Oral, Energy Intake, Exercise Test, Female, Humans, Leg, Methylhistidines, Muscle Proteins, Muscle, Skeletal, Myofibrils, Proline, Young Adult

ID: 38364393