Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients: a randomized crossover trial

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients : a randomized crossover trial. / Dall, C H; Snoer, M; Christensen, S; Monk-Hansen, T; Frederiksen, M; Gustafsson, F; Langberg, Henning; Prescott, E.

In: American Journal of Transplantation, Vol. 14, No. 10, 10.2014, p. 2391-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Dall, CH, Snoer, M, Christensen, S, Monk-Hansen, T, Frederiksen, M, Gustafsson, F, Langberg, H & Prescott, E 2014, 'Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients: a randomized crossover trial', American Journal of Transplantation, vol. 14, no. 10, pp. 2391-9. https://doi.org/10.1111/ajt.12873

APA

Dall, C. H., Snoer, M., Christensen, S., Monk-Hansen, T., Frederiksen, M., Gustafsson, F., ... Prescott, E. (2014). Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients: a randomized crossover trial. American Journal of Transplantation, 14(10), 2391-9. https://doi.org/10.1111/ajt.12873

Vancouver

Dall CH, Snoer M, Christensen S, Monk-Hansen T, Frederiksen M, Gustafsson F et al. Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients: a randomized crossover trial. American Journal of Transplantation. 2014 Oct;14(10):2391-9. https://doi.org/10.1111/ajt.12873

Author

Dall, C H ; Snoer, M ; Christensen, S ; Monk-Hansen, T ; Frederiksen, M ; Gustafsson, F ; Langberg, Henning ; Prescott, E. / Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients : a randomized crossover trial. In: American Journal of Transplantation. 2014 ; Vol. 14, No. 10. pp. 2391-9.

Bibtex

@article{455f41d1dd8c4ecbaeeec8b9fbe94043,
title = "Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients: a randomized crossover trial",
abstract = "In heart transplant (HTx) recipients, there has been reluctance to recommend high-intensity interval training (HIIT) due to denervation and chronotropic impairment of the heart. We compared the effects of 12 weeks' HIIT versus continued moderate exercise (CON) on exercise capacity and chronotropic response in stable HTx recipients >12 months after transplantation in a randomized crossover trial. The study was completed by 16 HTx recipients (mean age 52 years, 75{\%} males). Baseline peak oxygen uptake (VO2peak ) was 22.9 mL/kg/min. HIIT increased VO2peak by 4.9 ± 2.7 mL/min/kg (17{\%}) and CON by 2.6 ± 2.2 mL/kg/min (10{\%}) (significantly higher in HIIT; p < 0.001). During HIIT, systolic blood pressure decreased significantly (p = 0.037) with no significant change in CON (p = 0.241; between group difference p = 0.027). Peak heart rate (HRpeak ) increased significantly by 4.3 beats per minute (p = 0.014) after HIIT with no significant change in CON (p = 0.34; between group difference p = 0.027). Heart rate recovery (HRrecovery ) improved in both groups with a trend toward greater improvement after HIIT. The 5-month washout showed a significant loss of improvement. HIIT was well tolerated, had a superior effect on oxygen uptake, and led to an unexpected increase in HRpeak accompanied by a faster HRrecovery . This indicates that the benefits of HIIT are partly a result of improved chronotropic response.",
author = "Dall, {C H} and M Snoer and S Christensen and T Monk-Hansen and M Frederiksen and F Gustafsson and Henning Langberg and E Prescott",
note = "{\circledC} Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.",
year = "2014",
month = "10",
doi = "10.1111/ajt.12873",
language = "English",
volume = "14",
pages = "2391--9",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Effect of high-intensity training versus moderate training on peak oxygen uptake and chronotropic response in heart transplant recipients

T2 - a randomized crossover trial

AU - Dall, C H

AU - Snoer, M

AU - Christensen, S

AU - Monk-Hansen, T

AU - Frederiksen, M

AU - Gustafsson, F

AU - Langberg, Henning

AU - Prescott, E

N1 - © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

PY - 2014/10

Y1 - 2014/10

N2 - In heart transplant (HTx) recipients, there has been reluctance to recommend high-intensity interval training (HIIT) due to denervation and chronotropic impairment of the heart. We compared the effects of 12 weeks' HIIT versus continued moderate exercise (CON) on exercise capacity and chronotropic response in stable HTx recipients >12 months after transplantation in a randomized crossover trial. The study was completed by 16 HTx recipients (mean age 52 years, 75% males). Baseline peak oxygen uptake (VO2peak ) was 22.9 mL/kg/min. HIIT increased VO2peak by 4.9 ± 2.7 mL/min/kg (17%) and CON by 2.6 ± 2.2 mL/kg/min (10%) (significantly higher in HIIT; p < 0.001). During HIIT, systolic blood pressure decreased significantly (p = 0.037) with no significant change in CON (p = 0.241; between group difference p = 0.027). Peak heart rate (HRpeak ) increased significantly by 4.3 beats per minute (p = 0.014) after HIIT with no significant change in CON (p = 0.34; between group difference p = 0.027). Heart rate recovery (HRrecovery ) improved in both groups with a trend toward greater improvement after HIIT. The 5-month washout showed a significant loss of improvement. HIIT was well tolerated, had a superior effect on oxygen uptake, and led to an unexpected increase in HRpeak accompanied by a faster HRrecovery . This indicates that the benefits of HIIT are partly a result of improved chronotropic response.

AB - In heart transplant (HTx) recipients, there has been reluctance to recommend high-intensity interval training (HIIT) due to denervation and chronotropic impairment of the heart. We compared the effects of 12 weeks' HIIT versus continued moderate exercise (CON) on exercise capacity and chronotropic response in stable HTx recipients >12 months after transplantation in a randomized crossover trial. The study was completed by 16 HTx recipients (mean age 52 years, 75% males). Baseline peak oxygen uptake (VO2peak ) was 22.9 mL/kg/min. HIIT increased VO2peak by 4.9 ± 2.7 mL/min/kg (17%) and CON by 2.6 ± 2.2 mL/kg/min (10%) (significantly higher in HIIT; p < 0.001). During HIIT, systolic blood pressure decreased significantly (p = 0.037) with no significant change in CON (p = 0.241; between group difference p = 0.027). Peak heart rate (HRpeak ) increased significantly by 4.3 beats per minute (p = 0.014) after HIIT with no significant change in CON (p = 0.34; between group difference p = 0.027). Heart rate recovery (HRrecovery ) improved in both groups with a trend toward greater improvement after HIIT. The 5-month washout showed a significant loss of improvement. HIIT was well tolerated, had a superior effect on oxygen uptake, and led to an unexpected increase in HRpeak accompanied by a faster HRrecovery . This indicates that the benefits of HIIT are partly a result of improved chronotropic response.

U2 - 10.1111/ajt.12873

DO - 10.1111/ajt.12873

M3 - Journal article

C2 - 25135383

VL - 14

SP - 2391

EP - 2399

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 10

ER -

ID: 128556576