Effect of postsurgical rehabilitation programmes in patients operated for lung cancer: A systematic review and meta-analysis
Research output: Contribution to journal › Review › Research › peer-review
Maja S. Sommer, Maja E. B. Staerkind, Jan Christensen, Jette Vibe-Petersen, Klaus R Larsen, Jesper Holst Pedersen, Henning Langberg
OBJECTIVE: To review the evidence concerning the effects of postoperative exercise interventions on exercise capacity and health-related quality of life following resection for non-small cell lung cancer, and to review whether different initiation times of exercise produce different effects on exercise capacity.
DATA SOURCES: Comprehensive literature search of MEDLINE, Embase, CENTRAL, CINAHL and PEDro.
STUDY SELECTION: Randomized controlled trials examining the effects of exercise interventions were eligible for inclusion.
DATA EXTRACTION: Postoperative outcome measurements were extracted and the quality of evidence was graded using Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.
DATA SYNTHESIS: Four randomized controlled trials were identified involving 262 participants. Short-term follow-up (12-20 weeks) showed significantly higher exercise capacity and physical component of health-related quality of life in the intervention group (standardized mean difference (SMD) 0.48; 95% confidence interval (CI) 0.04-0.93) compared with the control group (SMD 0.50; 95% CI 0.19-0.82). There was no difference between the effect of late- and early-initiated exercise intervention.
CONCLUSION: Exercise has a small-to-moderate effect at short-term follow-up on exercise capacity and the physical component of health-related quality of life in patients operated for lung cancer. The long-term effects of exercise capacity are unknown. Early-initiated exercise programmes (2 weeks post-operation) did not show an effect on exercise capacity. These findings should be interpreted with caution.
|Journal||Journal of Rehabilitation Medicine|
|Number of pages||10|
|Publication status||Published - 2018|